Zobrazeno 1 - 10 of 46 pro vyhledávání: '"ATR protein"'
1
Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break
Autor: James E. Haber, Kevin Li, Jane Kondev, Gabriel Bronk
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance Creation of a chromosomal double-strand break (DSB) is rapidly accompanied by extensive phosphorylation of yeast histone H2A isoform (H2AX in mammals) by Mec1 (ATR) and Tel1 (ATM) protein kinases. This phosphorylation, termed γ-H2AX, sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5228b1a2d5703dd652d5f51bbb833d
http://europepmc.org/articles/PMC7474660
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2
Akademický článek
Cyclin A-Cdk1 Regulates the Origin Firing Program in Mammalian Cells
Autor: Katsuno, Yuko, Suzuki, Ayumi, Sugimura, Kazuto, Okumura, Katsuzumi, Zineldeen, Doaa H., Shimada, Midori, Niida, Hiroyuki, Mizuno, Takeshi, Hanaoka, Fumio, Nakanishi, Makoto, Mak, Tak Wah
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2009 Mar 01. 106(9), 3184-3189.
Externí odkaz: https://www.jstor.org/stable/40443290
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3
Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours
Autor: Martina Proctor, Mark N. Adams, Alexander J. Stevenson, Brian Gabrielli, Madushan Fernando, Anna Ehmann, Shivam Vora, Dubravka Skalamera, Pascal H.G. Duijf
Publikováno v: Oncogenesis, Vol 10, Iss 5, Pp 1-11 (2021)
Oncogenesis
Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations. DNA damage tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55c447f52915df53a2118004ae48b13
https://doi.org/10.1038/s41389-021-00329-8
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4
Breaking the DNA damage response to improve cervical cancer treatment
Publikováno v: CANCER TREATMENT REVIEWS. 42:30-40
Every year, cervical cancer affects similar to 500,000 women worldwide, and similar to 275,000 patients die of this disease. The addition of platin-based chemotherapy to primary radiotherapy has increased 5-year survival of advanced-stage cervical ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::6c2f04b8571e6d817a9a3b1592e298a6
https://research.rug.nl/en/publications/f42b8276-8509-4c1a-aedf-b2657c249a3b
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5
Breaking the DNA damage response to improve cervical cancer treatment
Autor: Marcel A. T. M. van Vugt, Elisabeth G.E. de Vries, Hylke W. Wieringa, Ate G.J. van der Zee
Publikováno v: CANCER TREATMENT REVIEWS. 42:30-40
Every year, cervical cancer affects similar to 500,000 women worldwide, and similar to 275,000 patients die of this disease. The addition of platin-based chemotherapy to primary radiotherapy has increased 5-year survival of advanced-stage cervical ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a6e28440fa407ec4017e9afaf6d3aa
https://hdl.handle.net/11370/f42b8276-8509-4c1a-aedf-b2657c249a3b
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6
Akademický článek
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7
Akademický článek
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8
LID - 10.1002/ardp.201700185 [doi]
Autor: Yavuz, Serkan, Cetin, Aysu, Akdemir, ATİLLA, Doyduk, Dogukan, Disli, Ali, Celik Turgut, Gurbet, Sen, Alaattin, Yildirir, Yilmaz
Cladribine (2-CdA) is used as an anti-cancer drug but is currently studied as a potential treatment for use in relapsing-remitting multiple sclerosis (MS). In this study, we computer designed, synthesized, and characterized two novel derivatives of 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::65426b3e4b42f2bfd94457327aee63b8
https://avesis.gazi.edu.tr/publication/details/30eeeddb-5331-44c3-860e-545fe0f6247c/oai
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9
Synthesis and Functional Investigations of Computer Designed Novel Cladribine-Like Compounds for the Treatment of Multiple Sclerosis
Autor: Yavuz, S., Çetin, A., Akdemir, A., Doyduk, D., Dişli, A., Çelik Turgut, G., Şen, Alaattin
Cladribine (2-CdA) is used as an anti-cancer drug but is currently studied as a potential treatment for use in relapsing-remitting multiple sclerosis (MS). In this study, we computer designed, synthesized, and characterized two novel derivatives of 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10652::de2b7246eb09a07891521335b2d223dd
https://doi.org/10.1002/ardp.201700185
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10
Akademický článek
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Plný text Recenzováno Digitální knihovna AV ČR
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