Výsledky vyhledávání - "ATPase binding"

Molecular mechanism of the MORC4 ATPase activation

Autor: Brian D. Strahl, Gregory M. Wright, Yi Zhang, Adam H. Tencer, Joshua C. Black, Christopher J. Petell, Tatiana G. Kutateladze, Brianna J. Klein, Michael G. Poirier, Khan L. Cox

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications

Human Microrchidia 4 (MORC4) is associated with acute and chronic pancreatitis, inflammatory disorders and cancer but it remains largely uncharacterized. Here, we describe the structure–function relationship of MORC4 and define the molecular mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e74f76bf054d00547c2765bca717b7
https://doaj.org/article/bae9c480125f473e8a017411be513b35

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Akademický článek

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

Autor: Braydon L. Burgess, Pamela F. Parkinson, Margaret M. Racke, Veronica Hirsch-Reinshagen, Jianjia Fan, Charmaine Wong, Sophie Stukas, Louise Theroux, Jeniffer Y. Chan, James Donkin, Anna Wilkinson, Danielle Balik, Brian Christie, Judes Poirier, Dieter Lütjohann, Ronald B. DeMattos, Cheryl L. Wellington

Publikováno v: Journal of Lipid Research, Vol 49, Iss 6, Pp 1254-1267 (2008)

Cholesterol homeostasis is of emerging therapeutic importance for Alzheimer's disease (AD). Agonists of liver-X-receptors (LXRs) stimulate several genes that regulate cholesterol homeostasis, and synthetic LXR agonists decrease neuropathological and

Externí odkaz: https://doaj.org/article/cdf2eaade54540b79ab0a478dcf20fe2

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Characterization of Inducible HSP70 Genes in an Antarctic Yeast, Glaciozyma antarctica PI12, in Response to Thermal Stress

Autor: Wan Nur Shuhaida Wan Mahadi, Jennifer Charles, Nur Athirah Yusof, Nor Muhammad Mahadi, Abdul Munir Abdul Murad

Publikováno v: Microorganisms
Volume 9
Issue 10
Microorganisms, Vol 9, Iss 2069, p 2069 (2021)

The induction of highly conserved heat shock protein 70 (HSP70) is often related to a cellular response due to harmful stress or adverse life conditions. In this study, we determined the expression of Hsp70 genes in the Antarctic yeast, Glaciozyma an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f82604ead81d491d820a8d02b7a6b19

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Akademický článek

Resolution of the Membrane Moiety of the H + -ATPase Complex into Two Kinds of Subunits

Autor: Sone, Nobuhito, Yoshida, Masasuke, Hirata, Hajime, Kagawa, Yasuo

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1978 Sep 01. 75(9), 4219-4223.

Externí odkaz: https://www.jstor.org/stable/68519

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Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo

Autor: Anja Irmisch, Eduard Campillo-Funollet, Alex Herbert, Mark A. Osborne, Hung Quang Dang, Johanne M. Murray, Antony W. Oliver, Antony M. Carr, Adam T. Watson, Thomas J. Etheridge, Desirée Villahermosa

Publikováno v: eLife
eLife, Vol 10 (2021)

The essential Smc5/6 complex is required in response to replication stress and is best known for ensuring the fidelity of homologous recombination. Using single-molecule tracking in live fission yeast to investigate Smc5/6 chromatin association, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04522181c5521c19a8cfd8691aa0a96
https://pubmed.ncbi.nlm.nih.gov/33860765

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Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo

Autor: Johanne M. Murray, Alex Herbert, Thomas J. Etheridge, Anja Irmisch, Mark A. Osborne, Antony W. Oliver, Hung Quang Dang, Eduard Campillo-Funollet, Adam T. Watson, Desirée Villahermosa, Antony M. Carr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d6060b34f68024df5abbc68fe815ec0
https://doi.org/10.1101/2020.06.19.148106

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Cinnamophilin overcomes cancer multi-drug resistance via allosterically modulating human P-glycoprotein on both drug binding sites and ATPase binding sites

Autor: I-Ting Wu, Shih-Ya Huang, Bo-Hau Huang, Yu-Ning Teng, Tian Shung Wu, Chin-Chuan Hung, Tsui-Er Lee

Publikováno v: Biomedicine & Pharmacotherapy, Vol 144, Iss, Pp 112379-(2021)

Cancer multi-drug resistance (MDR) caused by P-glycoprotein (P-gp) efflux is a critical unresolved clinical concern. The present study analyzed the effect of cinnamophilin on P-gp inhibition and MDR reversion. The effect of cinnamophilin on P-gp was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443da803085cbfef6e84b59af5d3432d
https://doi.org/10.1016/j.biopha.2021.112379

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In silico study directed towards identification of the key structural features of GyrB inhibitors targeting MTB DNA gyrase:HQSAR, CoMSIA and molecular dynamics simulations

Autor: James Spencer, Auradee Punkvang, Pornpan Pungpo, Pharit Kamsri, Khomson Suttisintong, Supa Hannongbua, Adrian J. Mulholland, Prasat Kittakoop

Publikováno v: Kamsri, P, Punkvang, A, Hannongbua, S, Suttisintong, K, Kittakoop, P, Spencer, J, Mulholland, A J & Pungpo, P 2019, ' In silico study directed towards identification of the key structural features of GyrB inhibitors targeting MTB DNA gyrase : HQSAR, CoMSIA and molecular dynamics simulations ', SAR and QSAR in Environmental Research, vol. 30, no. 11, pp. 775-800 . https://doi.org/10.1080/1062936X.2019.1658218

Mycobacterium tuberculosis DNA gyrase subunit B (GyrB) has been identified as a promising target for rational drug design against fluoroquinolone drug-resistant tuberculosis. In this study, we attempted to identify the key structural feature for high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be3fa0af0a86474864fd2b10022474e
http://www.scopus.com/inward/record.url?scp=85073158111&partnerID=8YFLogxK

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Novel anti-tubercular and antibacterial based benzosuberone-thiazole moieties: Synthesis, molecular docking analysis, DNA gyrase supercoiling and ATPase activity

Autor: Marwa M. Abdel-Aziz, Thoraya A. Farghaly, Ghada S. Masaret, Marwa F. Harras, Mohamed A. Omar, Eman M. H. Abbas

Publikováno v: Bioorganic Chemistry. 104:104316

Herein, molecular hybridization strategy was utilized in the design of new benzosuberone-thiazole derivatives. The structures of the synthesized hybrids were determined on the basis of elemental and spectral analyses. These compounds were evaluated f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683367dd7fc74da9a0ba2d7135c8bebc
https://doi.org/10.1016/j.bioorg.2020.104316

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An Overview of AAA+ Superfamily Proteins Associated Helicases

Autor: Nishat Passricha, Renu Tuteja, Narendra Tuteja, Shabnam K. Saifi

ATPases associated with various cellular functions (AAA+) superfamily is a group of various ATPases associated with diverse cellular functions and have multiple subcellular localizations. Members of this superfamily possess ATPase activity to perform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2697addc8259b0d7789e61650c1f40aa
https://doi.org/10.1016/b978-0-12-814685-9.00015-4

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