Zobrazeno 1 - 8 of 8 pro vyhledávání: '"ATP-Binding Cassette Transporters/genetics/metabolism"'
1
Pax6 Is a Key Component of Regulated Glucagon Secretion
Autor: Caroline Poisson, Mounia Heddad Masson, Jacques Philippe, Yvan Gosmain, Audrey Guérardel, Claire Cheyssac
Publikováno v: Endocrinology, Vol. 153, No 9 (2012) pp. 4204-15
The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4e08a66a1b2e4c08788194ee66248e
https://doi.org/10.1210/en.2012-1425
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2
Dual action antifungal small molecule modulates multidrug efflux and TOR signaling
Autor: Soo Chan Lee, Anne-Claude Gingras, Joseph Heitman, Paola Coccetti, Corey Nislow, Karolina Niewola-Staszkowska, Ron Ammar, Katja Döhl, A. A. Leslie Gunatilaka, Anna F. Averette, Taeyup Kim, David R. Andes, Yong Sun Bahn, Lutz Schmitt, E. M. Kithsiri Wijeratne, G. M. Kamal B. Gunaherath, Frederick P. Roth, Dominique Sanglard, Leah E. Cowen, Robbie Loewith, Farida Tripodi, Tanvi Shekhar-Guturja, Jean-Philippe Lambert
Publikováno v: Nature chemical biology
Nature chemical biology, vol. 12, no. 10, pp. 867-875
Nature chemical biology, Vol. 12, No 10 (2016) pp. 867-875
There is an urgent need for new strategies to treat invasive fungal infections, which are a leading cause of human mortality. Here, we establish two activities of the natural product beauvericin, which potentiates the activity of the most widely depl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df123ffb668df12b0d34f328ccb34f16
https://pubmed.ncbi.nlm.nih.gov/27571477
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3
How organic anions accumulate in hepatocytes lacking Mrp2: evidence in rat liver
Autor: Marcelle Moulin, Youssef Daali, Bruno Stieger, Philippe Millet, Catherine M. Pastor
Publikováno v: Journal of Pharmacology and Experimental Therapeutics, Vol. 336, No 3 (2011) pp. 624-32
The Journal of pharmacology and experimental therapeutics
In the liver, the accumulation of hepatobiliary contrast agents is a crucial issue to understand the images of liver scintigraphy or magnetic resonance (MR) imaging. Thus, depending on the regulation of uptake and exit membrane systems in normal and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff97cf27e5db87469b5d2eba08fefeb
https://archive-ouverte.unige.ch/unige:25212
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4
A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression
Autor: Vanessa Douet, Matthew B. Heller, Christopher M. VanWart, Olivier Le Saux, Ludovic Martin
Publikováno v: The American journal of pathology
The American journal of pathology, 2011, 178 (2), pp.774-83. ⟨10.1016/j.ajpath.2010.10.004⟩
International audience; beta-Thalassemia and pseudoxanthoma elasticum (PXE) are distinct genetic disorders. Yet, a dystrophic mineralization phenotype similar to PXE has frequently been associated with beta-thalassemia or sickle cell anemia patients
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c04da9f68677b45c42615f30b76004
https://pubmed.ncbi.nlm.nih.gov/21281810
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5
Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure
Autor: Christophe Albert Montessuit, René Lerch, Nadia Isidoro Tavares, Alex J. Baertschi, Pierre Philip-Couderc
Publikováno v: Cardiovascular research, Vol. 83, No 4 (2009) pp. 726-36
AIMS: Angiotensin II (Ang II) and tumour necrosis factor alpha (TNFalpha) are involved in the progression from compensated hypertrophy to heart failure. Here, we test their role in the remodelling of ATP-dependent potassium channel (K(ATP)) in heart
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d9589c271b47c7af86584940e9b846
https://archive-ouverte.unige.ch/unige:5299
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6
The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair
Autor: Zita Nagy, Jean-Yves Masson, Laszlo Tora, Flavie Robert, Ugo Déry, Céline Baldeyron, Rabih Murr, Dora Papadopoulo, Zdenko Herceg, Sara Hardy
Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2006, 26 (2), pp.402-12. ⟨10.1128/MCB.26.2.402-412.2006⟩
Molecular and Cellular Biology, Vol. 26, No 2 (2006) pp. 402-12
International audience; Transactivation-transformation domain-associated protein (TRRAP) is a component of several multiprotein histone acetyltransferase (HAT) complexes implicated in transcriptional regulation. TRRAP was shown to be required for the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15225db6ae18b0dbc80cfeaa756ba6b1
https://hal.archives-ouvertes.fr/hal-00188119
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7
Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function
Autor: Victor Bancila, Yukio Tanizawa, Eric Marthinet, Yoshimoto Oka, Jean-Michel Marie Maurice Dubuis, Valerie M. Schwitzgebel, Jacques Philippe, Alain Bloc, Bernhard Wehrle-Haller
Publikováno v: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No 9 (2005) pp. 5401-6
The ATP-sensitive potassium (K(ATP)) channel, assembled from the inwardly rectifying potassium channel Kir6.2 and the sulfonylurea receptor 1, regulates insulin secretion in beta-cells. A loss of function of K(ATP) channels causes depolarization of b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc150f50cd1407ac55cbd9f83c049a9d
https://archive-ouverte.unige.ch/unige:36659
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8
Abscisic acid transporters cooperate to control seed germination
Autor: Luis Lopez-Molina, Joohyun Kang, Youngsook Lee, Sojeong Yim, Hyunju Choi, Enrico Martinoia, A‐Reum Kim, Keun Pyo Lee
Publikováno v: Nature Communication
Nature Communications
Nature Communications, Vol. 6 (2015) P. 8113
NATURE COMMUNICATIONS(6)
Seed germination is a key developmental process that has to be tightly controlled to avoid germination under unfavourable conditions. Abscisic acid (ABA) is an essential repressor of seed germination. In Arabidopsis, it has been shown that the endosp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746757688ad16834db3566e306c65129
https://www.nature.com/articles/ncomms9113
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