β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel

Autor: Hannah R Foster, Thuong Ho, Evgeniy Potapenko, Sophia M Sdao, Shih Ming Huang, Sophie L Lewandowski, Halena R VanDeusen, Shawn M Davidson, Rebecca L Cardone, Marc Prentki, Richard G Kibbey, Matthew J Merrins

Publikováno v: eLife, Vol 11 (2022)

Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated KATP channel closure and insulin secretion. To identify the PK isoforms involved, we generated mice lacking β-cell PKm1, PKm2, and mitochondrial PEP c

Externí odkaz: https://doaj.org/article/fa152f2fa3f04b6c9965e3c25ec9218f

Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases

Autor: Jiaqi Fu, Mowei Zhou, Marina A Gritsenko, Ernesto S Nakayasu, Lei Song, Zhao-Qing Luo

Publikováno v: eLife, Vol 11 (2022)

The intracellular pathogen Legionella pneumophila delivers more than 330 effectors into host cells by its Dot/Icm secretion system. Those effectors direct the biogenesis of the Legionella-containing vacuole (LCV) that permits its intracellular surviv

Externí odkaz: https://doaj.org/article/480d563dc2e546f799a6efc7d1528c75

The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo

Autor: Cedric Bressan, Alessandra Pecora, Dave Gagnon, Marina Snapyan, Simon Labrecque, Paul De Koninck, Martin Parent, Armen Saghatelyan

Publikováno v: eLife, Vol 9 (2020)

Cell migration is a dynamic process that entails extensive protein synthesis and recycling, structural remodeling, and considerable bioenergetic demand. Autophagy is one of the pathways that maintain cellular homeostasis. Time-lapse imaging of autoph

Externí odkaz: https://doaj.org/article/6aac84dfd92240c1b74f536ee1a8e98c

Inhibition of plastid PPase and NTT leads to major changes in starch and tuber formation in potato

Autor: Andersson, Mariette, Turesson, Helle, Arrivault, Stéphanie, Zhang, Youjun, Fält, Ann-Sofie, Fernie, Alisdair R., Hofvander, Per

Publikováno v: Journal of Experimental Botany, 2018 Jan 01. 69(8), 1913-1924.

Externí odkaz: https://www.jstor.org/stable/26501786

Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

Autor: Marie-Sophie Nguyen-Tu, Joseph Harris, Aida Martinez-Sanchez, Pauline Chabosseau, Ming Hu, Eleni Georgiadou, Alice Pollard, Pablo Otero, Livia Lopez-Noriega, Isabelle Leclerc, Kei Sakamoto, Dieter Schmoll, David M. Smith, David Carling, Guy A. Rutter

Publikováno v: Nguyen-Tu, M-S, Harris, J, Martinez-Sanchez, A, Chabosseau, P, Hu, M, Georgiadou, E, Pollard, A, Otero, P, Lopez-Noriega, L, Leclerc, I, Sakamoto, K, Schmoll, D, Smith, D M, Carling, D & Rutter, G A 2022, ' Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase ', Diabetologia, vol. 65, pp. 997-1011 . https://doi.org/10.1007/s00125-022-05673-x

Aims/hypothesis Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous studies have used pharmacolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6227421373a23cecf46c480007056b6b
https://doi.org/10.1007/s00125-022-05673-x