Zobrazeno 1 - 10
of 1 084
pro vyhledávání: '"ATMP"'
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 5, Pp 533-546 (2024)
INTRODUCTION. The degree of processing (manipulation) of cells included in a cell product and the functions performed after administration (homologous/non-homologous use) determine the classification of the cell product as a transplant or an advanced
Externí odkaz:
https://doaj.org/article/96ac40fe76d347d489ab3c66b8f579db
Autor:
Ashis Kumar, Sowmya Ramesh, Lilian Walther-Jallow, Annika Goos, Vignesh Kumar, Åsa Ekblad, Vrisha Madhuri, Cecilia Götherström
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 324-333 (2024)
Introduction: Cell therapy has been increasingly considered to treat diseases, but it has been proven difficult to manufacture the same product at multiple manufacturing sites. Thus, for a wider implementation an alternative is to have one manufactur
Externí odkaz:
https://doaj.org/article/bfe0c0c6d9564680869fca5ec55230a6
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Plastic components are essential in the pharmaceutical industry, encompassing container closure systems, laboratory handling equipment, and single-use systems. As part of their material qualification process, studies on interactions between
Externí odkaz:
https://doaj.org/article/a9e48b2bcc5e4cc58888ef316ed17922
Autor:
Ana Bajc Česnik, Urban Švajger
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Mesenchymal stromal stem cells (MSCs) possess a remarkable potential for numerous clinical applications due to their unique properties including self-renewal, immunomodulation, paracrine actions and multilineage differentiation. However, the translat
Externí odkaz:
https://doaj.org/article/ba8c33af16f14dbbb1f359752d4db87b
Autor:
Lorenzo Giorgioni, Alessandra Ambrosone, Maria Francesca Cometa, Anna Laura Salvati, Robert Nisticò, Armando Magrelli
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10365 (2024)
Chimeric antigen receptor (CAR) T-cell therapy has achieved notable success in treating hematological cancers but faces significant challenges in solid-tumor treatment and overall efficacy. Key limitations include T-cell exhaustion, tumor relapse, im
Externí odkaz:
https://doaj.org/article/822099459a194a81a2f37623b96d96ab
Autor:
Daniel Josef Lindegger
Publikováno v:
Medical Sciences, Vol 12, Iss 3, p 33 (2024)
Human Immunodeficiency Virus (HIV) remains a significant global health challenge with approximately 38 million people currently having the virus worldwide. Despite advances in treatment development, the virus persists in the human population and stil
Externí odkaz:
https://doaj.org/article/6b74fc5a4ea84799b042ade72f92a17f
Autor:
Dominik Hotter, Marco Kunzelmann, Franziska Kiefer, Chiara Leukhardt, Carolin Fackler, Stefan Jäger, Johannes Solzin
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8076 (2024)
Infectivity assays are the key analytical technology for the development and manufacturing of virus-based therapeutics. Here, we introduce a novel assay format that utilizes label-free bright-field images to determine the kinetics of infection-depend
Externí odkaz:
https://doaj.org/article/e1adcd1023c74f8ebc04f71b68e474e6
Autor:
Ivana Ferrero, Sara Castiglia, Aloe Adamini, Alessandra Mandese, Francesca Sismondi, Deborah Rustichelli, Marco Leone, Giuseppe Pinnetta, Lucia Giordanengo, Katia Mareschi, Franca Fagioli
Publikováno v:
Translational Medicine Communications, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Background Media fills are used to demonstrate the adequacy of the aseptic conditions of a pharmaceutical production process, according to good manufacturing practice (GMP), using a growth medium in place of the product solution. For advance
Externí odkaz:
https://doaj.org/article/ea2493760cb44bf7a61dc73f267b04ce
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24715- (2024)
Background: Natural Killer (NK) cell-based therapies represent a ground-breaking opportunity for the treatment of solid tumors and hematological malignancies. NK cell manufacturing under good manufacturing practice (GMP) is complex and requires atten
Externí odkaz:
https://doaj.org/article/0e0bcecba162489b9b4362110cb46812
Autor:
I. Johanna, A. Daudeij, F. Devina, C. Nijenhuis, B. Nuijen, B. Romberg, C. de Haar, J. Haanen, H. Dolstra, E. Bremer, Z. Sebestyen, T. Straetemans, I. Jedema, J. Kuball
Publikováno v:
Immuno-Oncology and Technology, Vol 20, Iss , Pp 100411- (2023)
Following successes of authorized chimeric antigen receptor T-cell products being commercially marketed in the United States and European Union, product development of T-cell-based cancer immunotherapy consisting of cell-based advanced therapy medici
Externí odkaz:
https://doaj.org/article/c119a48014564075ab76aaf707787cb2