Výsledky vyhledávání - "ATKINSON, RA"

15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism

Autor: Abis, G, Charles, RL, Kopec, J, Yue, WW, Atkinson, RA, Bui, TTT, Lynham, S, Popova, S, Sun, Y-B, Fraternali, F, Eaton, P, Conte, MR

Publikováno v: Abis, G, Charles, R L, Kopec, J, Yue, W W, Atkinson, R A, Bui, T T T, Lynham, S, Popova, S, Sun, Y-B, Fraternali, F, Eaton, P & Conte, M R 2019, ' 15-deoxy-Δ 12,14-Prostaglandin J 2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism ', Communications Biology, vol. 2, no. 1, 188 . https://doi.org/10.1038/s42003-019-0426-2
Communications Biology
Communications Biology, Nature Publishing Group, 2019, 2 (1), ⟨10.1038/s42003-019-0426-2⟩
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)

Human soluble epoxide hydrolase (hsEH) is an enzyme responsible for the inactivation of bioactive epoxy fatty acids, and its inhibition is emerging as a promising therapeutical strategy to target hypertension, cardiovascular disease, pain and insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::171ef5494cea0bc031d1c2b36730d56c
http://ora.ox.ac.uk/objects/uuid:

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Autor: Annalisa Pastore, Geoff Kelly, Atkinson Ra, Frederick W. Muskett, Thomas A. Frenkiel, Catherine Joseph, Daniel Nietlispach

Publikováno v: Nature Structural Biology. 8:853-857

The interaction between α-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of a complex between the calcium-insensitive C-terminal EF-hand domain of α-actinin-2 and the seven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8a4d4c7c55340a3e176d4e3ba451869
https://doi.org/10.1038/nsb1001-853

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Letter to the Editor: Assignment of the H-1, C-13 and N-15 resonances of the C-terminal EF-hands of alpha-actinin in a 14 kDa complex with Z-repeat 7 of titin

Autor: Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Pastore A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4054::9b0a6f5eac31025c62ed188f37018d3a
https://hdl.handle.net/11384/76970

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Binding of alpha-actinin to titin: implications for Z-disk assembly

Autor: Atkinson RA, Joseph C, Dal Piaz F, Birolo L, Stier G, Pucci P, Pastore A, RI Dal Piaz Fabrizio/D-1843-2010

Publikováno v: Biochemistry

Titin is an exceptionally large protein (M.Wt. approximately 3 MDa) that spans half the sarcomere in muscle, from the Z-disk to the M-line. In the Z-disk, it interacts with alpha-actinin homodimers that are a principal component of the Z-filaments li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21983c45fad388eb7a8e0069d77af2b3
https://hdl.handle.net/21.11116/0000-0002-4743-321.11116/0000-0002-4745-1

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Isolation of Neospora caninum genes detected during a chronic murine infection

Autor: Atkinson, RA, Ryce, C, Miller, CMD, Balu, S, Harper, PAW, Ellis, JT

In order to isolate genes coding for antigens of Neospora caninum which are recognised by the host immune system during a chronic murine infection, a cDNA library was immunoscreened with pooled sera from mice which survived three independent infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::c380cd5320882f0fec6ce2d47759312f
https://hdl.handle.net/10453/3920

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