Výsledky vyhledávání - "ATF6, activating transcription factor 6"

Akademický článek

Endoplasmic Reticulum Stress Induced Proliferation Remains Intact in Aging Mouse β-Cells

Autor: Jarin T. Snyder, Christine Darko, Rohit B. Sharma, Laura C. Alonso

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Aging is associated with loss of proliferation of the insulin-secreting β-cell, a possible contributing factor to the increased prevalence of type 2 diabetes in the elderly. Our group previously discovered that moderate endoplasmic reticulum (ER) st

Externí odkaz: https://doaj.org/article/728bcb8b23a14288b1c2f25dfae7ce74

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Akademický článek

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence

Autor: Neha Shrestha, Elisa De Franco, Peter Arvan, Miriam Cnop

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

The notion that in diabetes pancreatic β-cells express endoplasmic reticulum (ER) stress markers indicative of increased unfolded protein response (UPR) signaling is no longer in doubt. However, what remains controversial is whether this increase in

Externí odkaz: https://doaj.org/article/80f01c138d2b45f0bc51193eba60b683

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Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition

Autor: Briony L. Gliddon, Craig T. Wallington-Beddoe, Manjun Li, Darren J. Creek, Melissa R. Pitman, Melinda N. Tea, Paul Wang, Dovile Anderson, John Toubia, Melissa K. Bennett, Robert Z. Orlowski, Stuart M. Pitson, Jason A. Powell

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 1, Pp 1-11 (2022)
Neoplasia (New York, N.Y.)

Refereed/Peer-reviewed The introduction of the proteasome inhibitor bortezomib into treatment regimens for myeloma has led to substantial improvement in patient survival. However, whilst bortezomib elicits initial responses in many myeloma patients,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4372e540234dd54ec39b9af964b760
http://www.sciencedirect.com/science/article/pii/S1476558621000993

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A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer

Autor: Yun Dai, Zhuo Yu, Dandan Sun, Hao Yang, Liu Song, Shulan Han, Caitriona M. O'Driscoll, Jianfeng Guo, Di Chu, Jie Ma, Yifang Zou

Publikováno v: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 378-393 (2022)
Acta Pharmaceutica Sinica. B

The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer (CRC). Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee6dd4b7090c45d73c9ae54ee9fd9f2
http://www.sciencedirect.com/science/article/pii/S2211383521002173

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Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer

Autor: Dat P. Ha, Yuan-Li Tsai, Amy S. Lee

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1213-1226 (2021)
Neoplasia (New York, N.Y.)

The 78 kilodalton glucose-regulated protein (GRP78) is a major endoplasmic reticulum (ER) molecular chaperone with antiapoptotic properties and a key regulator of the unfolded protein response (UPR). ER-stress induction of GRP78 in cancer cells repre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe6d3b1f9de1187a53014ad27063637
http://www.sciencedirect.com/science/article/pii/S1476558621000890

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Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in MiceSummary

Autor: Caroline Richard, Jean Buteau, John P. Kennelly, Tingting Ju, Stephanie Carlin, Ben P. Willing, Jelske N. van der Veen, Aducio Thiesen, René L. Jacobs, Randal Nelson

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 999-1021 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Patients with ulcerative colitis have low concentrations of the major membrane lipid phosphatidylcholine (PC) in gastrointestinal mucus, suggesting that defects in colonic PC metabolism might be involved in the development of coliti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cb572fe2a00cfe78b75990b8fc2494
http://www.sciencedirect.com/science/article/pii/S2352345X20301855

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Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis

Autor: Mingyang Shao, Qing Xu, Menglin Chen, Xiaoyue Cao, Chuan Li, Hong Bu, Yuwei Chen, Yuke Shu, Zhenru Wu, Gang Guo, Yuping Gong, Yongjie Zhou, Yujun Shi

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 633-651 (2021)

Background & Aims N6-methyladenosine (m6A), the most prevalent and dynamic posttranscriptional methylation modification of mammalian mRNA, is involved in various biological processes, but its role in liver regeneration has not been characterized. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07948b84c6263e6b798b7056d5735a81
https://doi.org/10.1016/j.jcmgh.2021.04.001

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Akademický článek

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The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury

Autor: Jie Cai, Xiaoge Zhang, Peng Chen, Yang Li, Songzi Liu, Qian Liu, Hanyong Zhang, Zhuyin Wu, Ke Song, Jianmiao Liu, Bo Shan, Yong Liu

Publikováno v: The Journal of Biological Chemistry

Hepatic ischemia/reperfusion (I/R) injury is an inflammation-mediated process arising from ischemia/reperfusion-elicited stress in multiple cell types, causing liver damage during surgical procedures and often resulting in liver failure. Endoplasmic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86338028f5113cd46609ec4ba5e153f
http://europepmc.org/articles/PMC8760522

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Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism

Autor: Lei Qian, Xinya Xie, Xin Nie, Nanping Wang, Erjiao Qiang, Jingyang Zhao, Wenfei Zhao, Zihui Zhang, Lei Xiao, Weiqi Tang, Chunmiao Yang

Publikováno v: Redox Biology, Vol 37, Iss, Pp 101728-(2020)
Redox Biology

Hyperglycemia-induced endothelial endoplasmic reticulum (ER) stress is implicated in the pathophysiology of diabetes and its vascular complications. Procyanidins are enriched in many plant foods and have been demonstrated to exert several beneficial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf0e03aa4920fa7a39d220fc5443287
http://www.sciencedirect.com/science/article/pii/S2213231720309332

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