Novel roles of KAT2A chromatin complexes ATAC and SAGA in normal and malignant haematopoiesis

Autor: De Jesus Arede, Liliana

Haematopoiesis is a dynamic process by which the full array of blood cell types originates from multipotent haematopoietic stem cells (HSCs). The blood system has long been an attractive model to explore how cell fate decisions are conducted at the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f7ad4d5e2db16a72827ecbf19f3b1b6

The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation

Autor: Edith E. Vamos, Imre Boros

Publikováno v: FEBS Letters. 586:3279-3286

ADA2 adaptor proteins are essential subunits of GCN5-containing histone acetyltransferase (HAT) complexes. In metazoa ADA2a is present in the histone H4-specific ATAC, and ADA2b in the histone H3-specific SAGA complex. Using domain-swapped ADA2 chime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6dbd4eba8976aea40ff158f7350149
https://doi.org/10.1016/j.febslet.2012.06.051

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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity.

Autor: Wang X; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Tianjin Medical University, Tianjin 300070, China., Wang L; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China., Zhou Z; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China., Jiang C; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China., Bao Z; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China., Wang Y; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Tianjin Medical University, Tianjin 300070, China., Zhang Y; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China., Song L; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China., Zhao Y; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China., Li X; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China., Li Q; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China., Shen Y; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Tianjin Medical University, Tianjin 300070, China., Yu Y; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Tianjin Medical University, Tianjin 300070, China. Electronic address: yuying@tmu.edu.cn., Mi W; Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. Electronic address: wenyi.mi@tmu.edu.cn.

Publikováno v: Cell reports [Cell Rep] 2024 Dec 05; Vol. 43 (12), pp. 115033. Date of Electronic Publication: 2024 Dec 05.

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex.

Autor: Merritt N; Department of Pathology, University of Iowa, Iowa City, United States., Garcia K; Department of Pathology, University of Iowa, Iowa City, United States.; Cancer Biology Graduate Program, University of Iowa, Iowa City, United States., Rajendran D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, United States., Lin ZY; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, United States., Zhang X; Peter MacCallum Cancer Centre, Melbourne, Australia., Mitchell KA; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia., Borcherding N; Department of Pathology and Immunology, Washington University, St. Louis, United States., Fullenkamp C; Department of Pathology, University of Iowa, Iowa City, United States., Chimenti MS; Iowa Institute of Human Genetics, Carver College of Medicine, University of Iowa, Iowa City, United States., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, United States., Harvey KF; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.; Department of Anatomy and Developmental Biology and Biomedicine Discovery Institute, Monash University, Clayton, Australia., Tanas MR; Department of Pathology, University of Iowa, Iowa City, United States.; Cancer Biology Graduate Program, University of Iowa, Iowa City, United States.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, United States.; Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Iowa City, United States.

Publikováno v: ELife [Elife] 2021 Apr 29; Vol. 10. Date of Electronic Publication: 2021 Apr 29.