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O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition

Autor: Gondane, A, Poulose, N, Walker, S, Mills, IG, Itkonen, HM

Publikováno v: Gondane, A, Poulose, N, Walker, S, Mills, I G & Itkonen, H M 2022, ' O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition ', Glycobiology, vol. 32, no. 9, pp. 751–759 . https://doi.org/10.1093/glycob/cwac038

Co-targeting of O-GlcNAc transferase (OGT) and the transcriptional kinase cyclin-dependent kinase 9 (CDK9) is toxic to prostate cancer cells. As OGT is an essential glycosyltransferase, identifying an alternative target showing similar effects is of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0278472963aab0895f4c15c16c09b545
http://hdl.handle.net/10138/347683

Inhibition of Cyclin-dependent Kinase (CDK) Decreased Survival of NB4 Leukemic Cells: Proposing a p53-Independent Sensitivity of Leukemic Cells to Multi-CDKs Inhibitor AT7519

Autor: Pourbagheri-Sigaroodi, Atieh, Safaroghli-Azar, Ava, Shanaki, Mehrnoosh, Yousefi, Amir-Mohammad, Anjam Najmedini, Ali, Bashash, Davood

Publikováno v: Iranian Journal of Pharmaceutical Research : IJPR

An unbounded number of events exist beneath the intricacy of each particular hematologic malignancy, prompting the tumor cells into an unrestrained proliferation and invasion. Aberrant expression of cyclin-dependent kinases (CDKs) is one of these eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4809ef5b1600f258f5888dacf3156672
http://europepmc.org/articles/PMC7758003

Selective Cdk9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish

Autor: Adriano G. Rossi, Aryan Kaveh, Finnius A. Bruton, Carl S. Tucker, Martin A. Denvir, Magdalena E. M. Oremek, John J. Mullins, Jonathan M. Taylor

Publikováno v: Development (Cambridge, England)
article-version (VoR) Version of Record
Kaveh, A, Bruton, F, Oremek, M, Tucker, C S, Taylor, J M, Mullins, J J, Rossi, A G & Denvir, M A 2021, ' Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish ', Development . https://doi.org/10.1242/dev.199636

Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse outcomes following myocardial infarction (MI). An attractive therapeutic strategy to treat MI is to reduce or remove infiltrating neutrophils to promote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd74b7f25500beb13a29ca4d6d16d23
https://pubmed.ncbi.nlm.nih.gov/34523672

CDK Blockade Using AT7519 Suppresses Acute Myeloid Leukemia Cell Survival through the Inhibition of Autophagy and Intensifies the Anti-leukemic Effect of Arsenic Trioxide

Autor: Mitra, Zabihi, Ava, Safaroghli-Azar, Ahmad, Gharehbaghian, Mehdi, Allahbakhshian Farsani, Davood, Bashash

Publikováno v: Iranian Journal of Pharmaceutical Research : IJPR

The strong storyline behind the critical role of cyclin-dependent kinase (CDK) inhibitor proteins in natural defense against malignant transformation not only represents a heroic perspective for these proteins, but also provides a bright future for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::816eda2d23cda37f744a57acd6f0f8ff
https://pubmed.ncbi.nlm.nih.gov/32802093