EZH2 inhibition reactivates epigenetically silenced FMR1 and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons

Autor: Minggang Fang, Sara K. Deibler, Pranathi Meda Krishnamurthy, Feng Wang, Paola Rodriguez, Shahid Banday, Ching-Man Virbasius, Miguel Sena-Esteves, Jonathan K. Watts, Michael R. Green

Publikováno v: Frontiers in Neuroscience, Vol 18 (2024)

Fragile X Syndrome (FXS) is a neurological disorder caused by epigenetic silencing of the FMR1 gene. Reactivation of FMR1 is a potential therapeutic approach for FXS that would correct the root cause of the disease. Here, using a candidate-based shRN

Externí odkaz: https://doaj.org/article/3a274fd2567945d28c750f6d92ecc94f

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Natural products, PGC-1 alpha, and Duchenne muscular dystrophy

Autor: Seyed Mohammad Nabavi, Samira Shirooie, Rosa Anna Vacca, Ipek Süntar, Tarun Belwal, Ana Sanches Silva, Antoni Sureda, Maryam Majidinia, Suowen Xu, Giuseppe D'Antona, Ahmad Reza Dehpour, Seyed Fazel Nabavi, Devesh Tewari, Eduardo Sobarzo-Sánchez, Bahman Yousefi, Maria Daglia

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 734-745 (2020)
Acta pharmaceutica sinica B
info:cnr-pdr/source/autori:Suntar I.; Sureda A.; Belwal T.; Sanches Silva A.; Vacca R.A.; Tewari D.; Sobarzo-Sanchez E.; Nabavi S.F.; Shirooie S.; Dehpour A.R.; Xu S.; Yousefi B.; Majidinia M.; Daglia M.; D'Antona G.; Nabavi S.M./titolo:Natural products, PGC-1alpha, and Duchenne muscular dystrophy/doi:10.1016%2Fj.apsb.2020.01.001/rivista:Acta pharmaceutica sinica B (Print)/anno:2020/pagina_da:734/pagina_a:745/intervallo_pagine:734–745/volume:10
Acta Pharmaceutica Sinica. B

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcriptional coactivator that binds to a diverse range of transcription factors. PPAR gamma coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e63841db77843060607354e31e90f64
https://hdl.handle.net/20.500.13003/17243

Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy

Autor: Amin Mahpour, Alan C. Mullen

Publikováno v: JHEP Reports
JHEP Reports, Vol 3, Iss 1, Pp 100177-(2021)

Summary: Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750e60e7a6db7fa02d59da3e28d12f2e
https://doi.org/10.1016/j.jhepr.2020.100177

A Review of Machine Perfusion Strategies in Liver Transplantation.

Autor: Banker A; Department of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India., Bhatt N; Department of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India., Rao PS; Department of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India., Agrawal P; Department of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India., Shah M; Department of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India., Nayak M; Department of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India., Mohanka R; Department of Liver Transplant and HPB Surgery, Sir HN Reliance Foundation Hospital, Mumbai, India.

Publikováno v: Journal of clinical and experimental hepatology [J Clin Exp Hepatol] 2023 Mar-Apr; Vol. 13 (2), pp. 335-349. Date of Electronic Publication: 2022 Aug 10.