Zobrazeno 1 - 10
of 2 778
pro vyhledávání: '"ASO"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 3802-3817 (2024)
Small nucleic acid drugs, composed of nucleotides, represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based therapeutics. These agents function by selectively targeting specific genes or
Externí odkaz:
https://doaj.org/article/5915be80fbe64a2ebe7f9e79127c8733
Autor:
Anastasiya Oshchepkova, Ivan Chernikov, Svetlana Miroshnichenko, Olga Patutina, Oleg Markov, Innokenty Savin, Yaroslav Staroseletz, Mariya Meschaninova, Pavel Puchkov, Sergey Zhukov, Maxim Kupryushkin, Mikhail Maslov, Aleksandra Sen’kova, Valentin Vlassov, Elena Chernolovskaya, Marina Zenkova
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
IntroductionSmall membrane particles called extracellular vesicles (EVs) transport biologically active cargo between cells, providing intercellular communication. The clinical application of EVs is limited due to the lack of scalable and cost-effecti
Externí odkaz:
https://doaj.org/article/fbe4b738750047829b8eb0b14ff074ec
Autor:
Tatiana Akimova, Liqing Wang, Zhanna Bartosh, Lanette M. Christensen, Evgeniy Eruslanov, Sunil Singhal, Veenu Aishwarya, Wayne W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Our goal is to improve the outcomes of cancer immunotherapy by targeting FOXP3+ T-regulatory (Treg) cells with a next generation of antisense oligonucleotides (ASO), termed FOXP3 AUMsilence ASO. We performed in vitro experiments with human healthy do
Externí odkaz:
https://doaj.org/article/a96f23f9055b414882bcdbc8711caf2b
Autor:
John J. Rossi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102153- (2024)
Externí odkaz:
https://doaj.org/article/cb5d072960484faebbb63c6ae9f795fa
Publikováno v:
Conservation, Vol 4, Iss 2, Pp 201-215 (2024)
Protected areas (PAs) such as national parks face funding issues that undermine effective management. Therefore, many PAs are exploring new financial instruments, such as visitor donations, to supplement their conservation budgets. This paper investi
Externí odkaz:
https://doaj.org/article/fb6ec023491f4961854a2972031a8ee2
Publikováno v:
Hematology Reports, Vol 16, Iss 1, Pp 151-163 (2024)
Inhibitors of the factor FXI represent a new class of anticoagulant agents that are facing clinical approval for the treatment of acute coronary syndrome (ACS), venous thromboembolism (VTE), and stroke prevention of atrial fibrillation (AF). These ne
Externí odkaz:
https://doaj.org/article/83996f99dfda433892c5dd06ff869f49
Autor:
Mohammad Reza Mirinezhad, Maliheh Aghsizadeh, Hamideh Ghazizadeh, Sahar Ghoflchi, Mohammad Zamiri Bidary, Alireza Naghipour, Gordon A. Ferns, Tayebeh Hamzehloei, Alireza Pasdar, Majid Ghayour-Mobarhan
Publikováno v:
BMC Women's Health, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background and aim premature ovarian insufficiency (POI) is defined as the menopause before 40 years of age, and its prevalence is reported to be two-fold higher in Iranian women than the average for woman globally. POI is associated with se
Externí odkaz:
https://doaj.org/article/b21b66d8fd694a58b9785684314e4265
Autor:
Yu Na Lim, In Soo Ryu, Yeon-Joo Jung, Gabriel Helmlinger, Insun Kim, Hye Won Park, Hansol Kang, Jina Lee, Hyo Jin Lee, Kang Seon Lee, Ha-Na Jang, Dae-In Ha, Junghyung Park, Jinyoung Won, Kyung Seob Lim, Chang-Yeop Jeon, Hyun-Jeong Cho, Hyun Su Min, Jin-Hyeob Ryu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102340- (2024)
l-Type amino acid transporter 1 (LAT1)-specific ligands and polyion complexes are used as brain-specific targets to deliver RNA-based drugs across the blood-brain barrier. We characterized an LAT1-targeting antisense oligonucleotide (ASO)-encapsulate
Externí odkaz:
https://doaj.org/article/75ccd5988ffe4c2d820c0368db49aea4
Autor:
Xiaochang Zhang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Pediatric neurological disorders are frequently devastating and present unmet needs for effective medicine. The successful treatment of spinal muscular atrophy with splice-switching antisense oligonucleotides (SSO) indicates a feasible path to target
Externí odkaz:
https://doaj.org/article/cd25d3966b8f4bccb3957936e641c3e3
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102184- (2024)
Nonalcoholic steatohepatitis (NASH) represents a severe disease subtype of nonalcoholic fatty liver disease (NAFLD) that is thought to be highly associated with systemic metabolic abnormalities. It is characterized by a series of substantial liver da
Externí odkaz:
https://doaj.org/article/ced1dfbe0c184e66b1ecb302d9383bfd