Zobrazeno 1 - 10
of 8 636
pro vyhledávání: '"ASK1"'
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Myocardial infarction (MI) is a major disease with high morbidity and mortality worldwide. However, existing treatments are far from satisfactory, making the exploration of potent molecular targets more imperative. The E3 ubiquiti
Externí odkaz:
https://doaj.org/article/e5e013e79a96405b917e2272239b3b6b
Autor:
Tiantian Xu, Yan Pan, Qinchao Ding, Feiwei Cao, Kaixin Chang, Jiannan Qiu, Hui Zhuge, Liuyi Hao, Haibin Wei, Caijuan Si, Xiaobing Dou, Songtao Li
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-19 (2024)
Abstract Background and aims Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related liver di
Externí odkaz:
https://doaj.org/article/79adc6271fe9423e93a742435617c078
Autor:
Xiaorui Han, Pingping Lan, Qianfeng Chen, Hua Liu, Zhongwen Chen, Tiantian Wang, Zengtao Wang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Inhibiting apoptosis signal regulated kinase 1 (ASK1) is an attractive strategy for treating diseases such as non-alcoholic steatohepatitis and multiple sclerosis. Here, we report the discovery of a dibromo substituted quinoxaline fragment containing
Externí odkaz:
https://doaj.org/article/3cae62aaeca548e1aca3f8b16fd97d34
Akademický článek
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Autor:
Yun Zhou, Shi-Xiong Liu, Ya Zheng, Sheng-Rui Song, Yi-Bo Cao, Yu-Qing Qao, Yong-Ning Zhou, Yu-Ping Wang
Publikováno v:
Journal of Functional Foods, Vol 119, Iss , Pp 106327- (2024)
Gastric carcinoma (GC) is one of the most common malignant tumors worldwide, and ranks fifth in incidence and top 5 in tumor-associated mortality. Unfortunately, the molecular mechanisms contributing to GC development are still unclear, urgently requ
Externí odkaz:
https://doaj.org/article/2c75d9051e3e401782b39c735755c191
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-28 (2024)
Abstract In the current study we suggest a novel approach to curb non-alcoholic steatohepatitis (NASH) progression, and we suggest privileged scaffolds for the design of novel compounds for this aim. NASH is an advanced form of non-alcoholic fatty li
Externí odkaz:
https://doaj.org/article/82e08e6c83ee4375ab8dbf2e4eb6e07b
Autor:
Jiaxuan He, Siyuan Li, Yunpeng Teng, Hongfei Xiong, Zhuang Wang, Xiaoyao Han, Wei Gong, Ya Gao
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
AbstractDual-specificity phosphatase 12 (DUSP12) is abnormally expressed under various pathological conditions and plays a crucial role in the pathological progression of disorders. However, the role of DUSP12 in cerebral ischaemia/reperfusion injury
Externí odkaz:
https://doaj.org/article/296751f4cf244c938fe9fae03bf73efe
Publikováno v:
eLife, Vol 13 (2024)
Apoptosis signal-regulating kinase 1 (ASK1) is a crucial stress sensor, directing cells toward apoptosis, differentiation, and senescence via the p38 and JNK signaling pathways. ASK1 dysregulation has been associated with cancer and inflammatory, car
Externí odkaz:
https://doaj.org/article/fbfd17cff81c4de6912edeec406e7563
Autor:
Shan Meng, Hui Cao, Yichen Huang, Ziyu Shi, Jiaying Li, Yana Wang, Yue Zhang, Shuning Chen, Hong Shi, Yanqin Gao
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Background Traumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various central nervous system (CNS) diseases, has garnered in
Externí odkaz:
https://doaj.org/article/0068dd6e4f3040a8943a6289cf06cede
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
The dopaminergic system is susceptible to dysfunction in numerous neurological diseases, including Parkinson’s disease (PD). In addition to motor symptoms, some PD patients may experience non-motor symptoms, including cognitive and memory deficits.
Externí odkaz:
https://doaj.org/article/d14320a61dc248b5a1a592f702f96c8f