Zobrazeno 1 - 10
of 1 262
pro vyhledávání: '"ASCL1"'
Publikováno v:
Biomolecules & Biomedicine (2024)
The purpose of this research was to clarify the function of achaete-scute family bHLH transcription factor 1 (ASCL1) and solute carrier family 6 member 13 (SLC6A13) in influencing tumor cell behavior, inflammatory responses, and the regulation of inf
Externí odkaz:
https://doaj.org/article/4ce139f6a9374c9ca7e0d0c22dfb2682
Autor:
Yilun Li, Xiaolu Yang, Cuizhi Geng, Yunjiang Liu, Tiantian Tang, Lina Zhang, Fei Liu, Meng Zhang, Jun Hao, Li Ma
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveThe aim of this study was to identify the molecular subtypes of breast cancer based on chromatin regulator-related genes.MethodsThe RNA sequencing data of The Cancer Genome Atlas–Breast Cancer cohort were obtained from the official website
Externí odkaz:
https://doaj.org/article/21c132ec80da49388839b4d1130b3a4f
Autor:
Carolina Purcell Goes, Vitória Samartin Botezelli, Shirley Mirna De La Cruz, Mário Costa Cruz, Ana Paula Azambuja, Marcos Simoes-Costa, Chao Yun Irene Yan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
ASCL1 is a transcription factor that directs neural progenitors towards lineage differentiation. Although many of the molecular mechanisms underlying its action have been described, several of its targets remain unidentified. We identified in the chi
Externí odkaz:
https://doaj.org/article/7ae34aa2b4ad44d7a953d36ceb13c1c6
Autor:
Sehhoon Park, Tae Hee Hong, Soohyun Hwang, Simon Heeke, Carl M. Gay, Jiyeon Kim, Hyun-Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Jong Ho Cho, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Hong Kwan Kim, Lauren Averett Byers, John V. Heymach, Yoon-La Choi, Se-Hoon Lee, Keunchil Park
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105062- (2024)
Summary: Background: Recent studies have reported the predictive and prognostic value of novel transcriptional factor-based molecular subtypes in small-cell lung cancer (SCLC). We conducted an in-depth analysis pairing multi-omics data with immunohis
Externí odkaz:
https://doaj.org/article/40a1e82c84034502bbbe4835972d5109
Publikováno v:
Cells, Vol 13, Iss 14, p 1223 (2024)
Neuronal reprogramming is a promising approach for making major advancement in regenerative medicine. Distinct from the approach of induced pluripotent stem cells, neuronal reprogramming converts non-neuronal cells to neurons without going through a
Externí odkaz:
https://doaj.org/article/364fcf833d5d46fa933f463b993844e7
Autor:
Kirstin O. McDonald, Nikita M. A. Lyons, Luca K. C. Gray, Janet B. Xu, Lucia Schoderboeck, Stephanie M. Hughes, Indranil Basak
Publikováno v:
Cells, Vol 13, Iss 12, p 1016 (2024)
Dopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been g
Externí odkaz:
https://doaj.org/article/9dd4689e35f045f190896ade8ce2164e
Publikováno v:
Journal of Advanced Biomedical Sciences, Vol 13, Iss 3, Pp 175-184 (2023)
Background & Objective: The aim of this study was to investigate the effect of saffron extract on the embryo development of mice. Materials & Methods: Pregnant NMRI mice were randomized into control and treatment groups at 25, 50, and 100 mg/kg saffr
Externí odkaz:
https://doaj.org/article/999cc6146a664aeebdc2036155ee98cb
Autor:
Kengo Yasuda, Tomohiro Haruki, Tatsuya Miyamoto, Yuki Oshima, Shinji Matsui, Yasuaki Kubouchi, Hiroshige Nakamura
Publikováno v:
Thoracic Cancer, Vol 14, Iss 20, Pp 2001-2004 (2023)
Abstract Several transcription factors in small cell lung cancer (SCLC), including achaete‐scute homolog 1 (ASCL1) and neurogenic differentiation factor 1 (NEUROD1), contribute to rapid tumor growth and early metastatic dissemination. Recent studie
Externí odkaz:
https://doaj.org/article/9aa0d2f72c1942a1a7939e816b7d33a5
Autor:
Anna B. Osipovich, Frank Y. Zhou, Judy J. Chong, Linh T. Trinh, Mathew A. Cottam, Shristi Shrestha, Jean-Philippe Cartailler, Mark A. Magnuson
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101811- (2023)
Objective: ASCL1, a pioneer transcription factor, is essential for neural cell differentiation and function. Previous studies have shown that Ascl1 expression is increased in pancreatic β-cells lacking functional KATP channels or after feeding of a
Externí odkaz:
https://doaj.org/article/c960991850aa4a3a86d2b2985abf0881
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-28 (2023)
Abstract Assay for Transposase-Accessible Chromatin with sequencing (ATAC-seq) reveals chromatin accessibility across the genome. Currently, no method specifically detects differential chromatin accessibility. Here, SeATAC uses a conditional variatio
Externí odkaz:
https://doaj.org/article/d56d0fbeef97442287bbd3c39241eadc