Xenobiotic receptors in mediating the effect of sepsis on drug metabolism

Autor: Chuanzhu Lv, Ling Huang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 33-41 (2020)

Sepsis is an infection-induced systemic inflammatory syndrome. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways. When sepsis occurs, the expression and activity of many inflammato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb8372fdf8db9b4e0412d71c8bb0848
http://europepmc.org/articles/PMC6977532

CYP polymorphisms and pathological conditions related to chronic exposure to organochlorine pesticides

Autor: Kirill S. Golokhvast, Nikolaos Drakoulis, Izotov Bn, Domniki Fragou, Alexander M. Zakharenko, Dimitrios Petrakis, Leda Kovatsi, Concettina Fenga, Anca Oana Docea, Alexander E. Nosyrev, Antonis Vakis, Valerii N. Rakitskii, Loukia Vassilopoulou, Andreea Letitia Arsene, Christina Tsitsimpikou

Publikováno v: Toxicology Reports, Vol 4, Iss, Pp 335-341 (2017)
Toxicology Reports

Graphical abstract
Highlights • Organochlorine compounds (OCs) are persistent organic pollutants acting as endocrine disruptors. • Exposure to OCs is a risk factor for several severe pathologies. • Specific CYP polymorphisms could affect t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020aeb3215524fd7d4f72dffcab1517b
https://doi.org/10.1016/j.toxrep.2017.05.007

Dimethyl-Benz(a)anthracene: A mammary carcinogen and a neuroendocrine disruptor

Autor: Bernard Kerdelhué, Xavier Coumoul, Claude Forest

Publikováno v: Biochimie Open
Biochimie Open, 2016, 3, pp.49-55. ⟨10.1016/j.biopen.2016.09.003⟩
Biochimie Open, Vol 3, Iss C, Pp 49-55 (2016)

Polycyclic Aromatic Hydrocarbons (PAHs) are potent carcinogens. Among these, dimethylbenz(a)anthracene (DMBA) is well known for its capacity to induce mammary carcinomas in female Sprague-Dawley (SD) rats. Ovariectomy suppresses the susceptibility of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3207d097d32ce43e8328364ed9f48bee

Characterization of marine-derived halogenated indoles as ligands of the aryl hydrocarbon receptor.

Autor: King J; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand., Woolner VH; School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand.; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand., Keyzers RA; School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand., Rosengren RJ; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.

Publikováno v: Toxicology reports [Toxicol Rep] 2022 May 25; Vol. 9, pp. 1198-1203. Date of Electronic Publication: 2022 May 25 (Print Publication: 2022).

Xenobiotic receptors in mediating the effect of sepsis on drug metabolism.

Autor: Lv C; Department of Emergency, Hainan Clinical Research Center for Acute and Critical Diseases, The Second Affiliated Hospital of Hainan Medical University, Haikou 570300, China.; Emergency and Trauma College, Hainan Medical University, Haikou 571101, China.; Research Unit of Island Emergency Medicine, Chinese Academy of Medical Sciences, Hainan Medical University, Haikou 571101, China.; Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University, Haikou 571101, China., Huang L; Research Center for Drug Safety Evaluation of Hainan Province, Hainan Medical University, Haikou 571101, China.; Hainan Province Key Laboratory for Drug Preclinical Study of Pharmacology and Toxicology Research, Hainan Medical University, Haikou 571101, China.; Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University, Haikou 571101, China.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Jan; Vol. 10 (1), pp. 33-41. Date of Electronic Publication: 2019 Dec 16.