RNA interference : a strategy for targeting protein kinase B (Akt) in hepatocellular carcinoma

Autor: Mroweh, Mariam

Publikováno v: Virologie. Université Grenoble Alpes [2020-..]; Université Libanaise, 2022. Français. ⟨NNT : 2022GRALV031⟩

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide, and its incidence is rising. HCC develops almost exclusively on the background of chronic liver inflammation, which can be caused by chronic alcohol c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::739f46081ce0883e2ee96da385e9b135
https://theses.hal.science/tel-03771336

L'interaction entre le suppresseur de l’ARN interférence du BNYVV et sa cible DRB4 est modulée par un ARN viral non codant

Autor: Bellott, Lucie

In plants, RNA silencing (RNAi) is an antiviral defense mechanism involving DCL proteins and their associated DRB proteins. To overcome RNAi, phytoviruses express viral suppressors RNA silencing, or VSRs. Beet yellow necrotic vein virus (BNYVV) RNA1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______166::b30ba4173c1cc9ae4bcc8cea69377d8e
https://theses.hal.science/tel-03934772

Modeling In Vitro & In Vivo Radiotherapy Resistance in Diffuse Intrinsic Pontine Gliomas (DIPG)

Autor: Werbrouck, Coralie

Publikováno v: Cancer. Université Paris-Saclay, 2020. Français. ⟨NNT : 2020UPASL001⟩

Diffuse intrinsic pontine gliomas (DIPG) are the most severe pediatric brain tumours. Though accepted as the main therapeutic, radiotherapy is only transiently efficient and not even in every patient. We previously identified a heterogeneous response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::33bc4c5d2b2b91eec43059f47bc3d6b6
https://theses.hal.science/tel-03618052/document

Le facteur de transcription antioxydant NRF2 comme nouveau régulateur de la matrice extracellulaire des fibroblastes de peau humaine

Autor: Salamito, Mélanie

The nuclear factor-erythroid 2-related factor 2 (NRF2) is a transcription factor involved in cell defense against oxidative and xenobiotic stresses. SKN-1, the nematode homologue of NRF2 is a master regulator of longevity that, under specific metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______166::68cbd2431c63007f95143940ae13132b
https://theses.hal.science/tel-03640891

Analyse fonctionnelle d’une symbiose mutualiste : mécanismes de production du polydnavirus associé au parasitoïde ichneumonide Hyposoter didymator

Autor: Lorenzi, Ange

Publikováno v: Parasitologie. Université Montpellier, 2019. Français. ⟨NNT : 2019MONTG047⟩
Sciences agricoles. Université Montpellier, 2019. Français. ⟨NNT : 2019MONTG047⟩

PDVs are DNA viruses associated with tens of thousands of parasitoid hymenopteran species. They are divided into two taxa, the Bracoviruses (BVs) and the Ichnoviruses (IVs) associated respectively with the subfamilies of Braconidae and Ichneumonidae.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ec23a6fb78e84971440318118207b1ce
https://tel.archives-ouvertes.fr/tel-02488880