Zobrazeno 1 - 10
of 2 480
pro vyhledávání: '"ARID1A"'
Autor:
Daichi Kodama, Motoki Takenaka, Chiemi Saigo, Masako Azuma, Yuki Hanamatsu, Masanori Isobe, Tamotsu Takeuchi
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-9 (2024)
Abstract Recent studies have revealed that the Sry-related HMG box gene 17 (SOX17) plays an important role in ovarian carcinogenesis. Unlike other types of ovarian cancer, ovarian clear cell carcinoma (OCCC) has a distinct pathobiological phenotype,
Externí odkaz:
https://doaj.org/article/4ec6e70f56cb410595753ad7e2517d24
Autor:
Dan-ni Wu, Kang-liang Zhang, Rui-heng Chen, Wen-sheng Ye, Chong Zheng, Yuan-liang Zheng, Xiao-dan Zhao, Ri-sheng Huang
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Loss of ARID1A has been reported to drive the progression of lung adenocarcinoma, yet the underlying mechanism remains elusive. In this study, we performed secretome analysis to identify the key secreted proteins regulating lung adenocarcino
Externí odkaz:
https://doaj.org/article/f194eb14bede409ca09f75fd397ecd44
Autor:
Rong-Sheng Qin, Chun-Tao Li, Fei Chen, Shu Luo, Chao Wang, Jie Li, Shan Xu, MingWei Kang, Hao-Wen Hu
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Purpose Mutations in ARID1A frequently occur in colorectal cancer (CRC) cells. However, there are currently no clinical treatment options specifically addressing this aberration. The preliminary in vitro experiments revealed a synthetic leth
Externí odkaz:
https://doaj.org/article/2cf709620bbf48d5b587d9ef55f2ed6a
Autor:
Jin-Peng Ke, Bao-Dong He, Mao-Lei Gong, Zhong-Ze Yan, Hong-Zhen Du, Zhao-Qian Teng, Chang-Mei Liu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Traumatic brain injury (TBI) is an acquired insult to the brain caused by an external mechanical force, potentially resulting in temporary or permanent impairment. Microglia, the resident immune cells of the central nervous system, are activ
Externí odkaz:
https://doaj.org/article/650d2c42faf2463895c0f773f06657c7
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background The poor chemo-response and high DNA methylation of ovarian clear cell carcinoma (OCCC) have attracted extensive attentions. Recently, we revealed the mutational landscape of the human kinome and additional cancer-related genes an
Externí odkaz:
https://doaj.org/article/7e05d7621a8d43ec80cfcd7cf39e9fd9
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 204-30 (2024)
Borderline ovarian tumours (BOTs) show intriguing characteristics distinguishing them from other ovarian tumours. The aim of the systematic review was to analyse the spectrum of molecular changes found in BOTs and discuss their significance in the co
Externí odkaz:
https://doaj.org/article/61b5980ba5e544b385458d81e31cafd0
Autor:
Hai Zhou, Dantong Sun, Shanai Song, Yurong Niu, Yuming Zhang, Hongwei Lan, Jiali Cui, Houde Liu, Ning Liu, Helei Hou
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Background Immune checkpoint inhibitors (ICIs), especially those targeting programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1), have introduced a new treatment landscape for many types of tumors. However, they only achi
Externí odkaz:
https://doaj.org/article/bced8f661c30458c8cb8acbead51cd59
Autor:
Tianyu Zhu, Qian Li, Zhe Zhang, Jiahao Shi, Yongyun Li, Feng Zhang, Lingjie Li, Xin Song, Jianfeng Shen, Renbing Jia
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is thought to play a significant role both in tumor suppression and tumor initiation, which is highly dependent upon context. Previous studies have suggested that ARID
Externí odkaz:
https://doaj.org/article/d2a37a9f071e4860b30d34cde1171454
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Objective AT-rich interaction domain 1A (ARID1A) mutant tumors show active anti-tumor immune response, which is the potential indication of immunotherapy. However, the relationship between the heterogeneous ARID1A expression and the immune r
Externí odkaz:
https://doaj.org/article/53ebfd418e61444584bb0f2d4d19476f
Autor:
Fangqi Ma, Mingming Ren, Zhongqiu Li, Yujing Tang, Xiaoyu Sun, Yi Wang, Nida Cao, Xiaohong Zhu, Yan Xu, Rui Wang, Yumiao Shen, Ruohan Zhao, Zhaoyan Li, Milad Ashrafizadeh, Gautam Sethi, Furong Wang, Aiguang Zhao
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107499- (2024)
ARID1A deletion mutation contributes to improved treatment of several malignancies with immune checkpoint inhibitors (ICIs). However, its role in modulating of tumor immune microenvironment (TIME) of gastric cancer (GC) remains unclear. Here, we repo
Externí odkaz:
https://doaj.org/article/6edfe2f16e934a929e551f3d8ed57aab