Zobrazeno 1 - 10
of 13
pro vyhledávání: '"AREG, amphiregulin"'
Autor:
Wolfgang Walther, Annika Wulf-Goldenberg, Ulrike Stein, Johannes Merk, Iduna Fichtner, Keziban M. Alp, Giannino Patone, Tamara Kanashova, Christine Sers, Philipp Mertins, Maria Rivera, Jens Hoffmann
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 21-35 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 21-35 (2021)
Patient-derived xenograft (PDX) tumor models represent a valuable platform for identifying new biomarkers and novel targets, to evaluate therapy response and resistance mechanisms. This study aimed at establishment, characterization and therapy testi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8082ec6c5f41c16d128a521a50759417
https://doi.org/10.1016/j.neo.2020.11.005
https://doi.org/10.1016/j.neo.2020.11.005
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Celiac disease (CD) is a common autoimmune disorder triggered by the ingestion of gluten in genetically susceptible individuals. Although the mechanisms underlying gliadin-mediated activation of adaptive immunity in CD have been well-characterized, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e702a75de5957371ae55d9bcbdb2bcd7
https://doi.org/10.1016/j.jcmgh.2020.12.002
https://doi.org/10.1016/j.jcmgh.2020.12.002
Akademický článek
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Autor:
Kaori Okinaka, Goshi Shiota, Hiroyuki Oka, Tsuyoshi Yokobata, Shizuma Okazaki, Ikuya Noda, Minoru Morimoto, Noriko Itaba, Yohei Kono
Publikováno v:
Regenerative Therapy, Vol 9, Iss, Pp 45-57 (2018)
Regenerative Therapy
Regenerative Therapy
Introduction We previously reported that transplantation of hepatic cell sheets from human bone marrow-derived mesenchymal stem cells (BM-MSCs) with hexachlorophene, a Wnt/β-catenin signaling inhibitor, ameliorated acute liver injury. In a further p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d56c4d56ae22c9ffa2f008940c3783
http://www.sciencedirect.com/science/article/pii/S2352320418300142
http://www.sciencedirect.com/science/article/pii/S2352320418300142
Autor:
Roxanne Pillay, Nomzamo Nembe, Zamathombeni Duma, Rajen N. Naidoo, Miranda N. Mpaka-Mbatha, Ravesh Singh, Pragalathan Naidoo, Zilungile L. Mkhize-Kwitshana, Veron Ramsuran, Terisha Ghazi, Khethiwe N. Bhengu, Anil A. Chuturgoon
Publikováno v:
Environment International
Environment International, Vol 156, Iss, Pp 106695-(2021)
Environment International, Vol 156, Iss, Pp 106695-(2021)
Soil-transmitted helminths infect billions of people globally, particularly those residing in low- and middle-income regions with poor environmental sanitation and high levels of air and water pollution. Helminths display potent immunomodulatory acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba13a29c256e957fb5ca4f051ffe93d
http://europepmc.org/articles/PMC8205275
http://europepmc.org/articles/PMC8205275
AREG contributes to the diminished PICD of neonatal monocytes by EGFR-mediated apoptosis suppression
Autor:
Platen, Christopher
Publikováno v:
Aachen 1 Online-Ressource (XII, 96 Seiten, Seite XIII-LIII) (2018). doi:10.18154/RWTH-2018-231215 = Dissertation, RWTH Aachen University, 2018
Dissertation, RWTH Aachen University, 2018; Dissertation, RWTH Aachen University, 2018
Neonates are highly susceptible to microbial infections, resulting in nearly 1 million neonatal deaths per year. This predisposition is particularly referable
Neonates are highly susceptible to microbial infections, resulting in nearly 1 million neonatal deaths per year. This predisposition is particularly referable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec1f1634848a4c07bd5ecb87e517f1b
Autor:
Guanglin Xu, Ying Wang, Li Hu, Yuanyuan Cao, Yawen Sun, Ziwei Hu, Yaping Hao, Jinling Xu, Weijie Li
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 324-334 (2018)
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 324-334 (2018)
COX-2 and YAP are shown to be highly associated with hepatocellular carcinoma (HCC) and frequently upregulated during tumor formation. However, despite their importance, whether there is a mutual interaction between COX-2 and YAP and how they regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0efefd4d31e197c1d3c005286d8276
https://pubmed.ncbi.nlm.nih.gov/29505957
https://pubmed.ncbi.nlm.nih.gov/29505957
Publikováno v:
Biochemical Journal
ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors, contributing differentially to transcriptomic profiles. In cardiomyocytes ERK1/2 are required for >
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9ea954d433660d58ba0f0f41fde7cd
http://europepmc.org/articles/PMC3573779
http://europepmc.org/articles/PMC3573779
Autor:
Angela Clerk, Peter H. Sugden, Marcus J. Tindall, Alejandro Giraldo, Emre Amirak, Bonhi S. Bhattacharya, Stephen J. Fuller, Oliver P. T. Barrett
Publikováno v:
Biochemical Journal
Endothelin-1 promotes cardiomyocyte hypertrophy by inducing changes in gene expression. Immediate early genes including Atf3 (activating transcription factor 3), Egr1 (early growth response 1) and Ptgs2 (prostaglandin-endoperoxide synthase 2) are rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f587ad5e9c456efdc0e164ae3ba47b0
https://doi.org/10.1042/bj20120125
https://doi.org/10.1042/bj20120125
Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression.
Autor:
Wang P; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Wang M; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Hu Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Chen J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Cao Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Liu C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Wu Z; Department of Cardiac Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China., Shen J; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China., Lu J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Liu P; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Engineering Laboratory of Druggability and New Drugs Evaluation, Guangzhou 510006, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Mar; Vol. 11 (3), pp. 680-693. Date of Electronic Publication: 2020 Nov 01.