RAAS inhibition and the course of Alport syndrome

Autor: Savva, Isavella, Pierides, Alkis M., Constantinou-Deltas, Constantinos D.

Publikováno v: Pharmacological Research
Pharmacol.Res.

Alport syndrome (AS) is a hereditary progressive glomerulonephritis with a high life-time risk for end-stage renal disease (ESRD). Most patients will reach ESRD before the age of 30 years, while a subset of them with milder mutations will do so at ol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362bff02e6ee22962933c0166d7ce16c
https://pubmed.ncbi.nlm.nih.gov/26995302

A glycine substitution in the collagenous domain of Col4a3 in mice recapitulates late onset Alport syndrome.

Autor: Odiatis C; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus., Savva I; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus., Pieri M; Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, Cyprus., Ioannou P; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus., Petrou P; Department of Biochemistry, The Cyprus Institute of Neurology and Genetics, Cyprus., Papagregoriou G; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus., Antoniadou K; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus., Makrides N; Department of Developmental Functional Genetics, The Cyprus Institute of Neurology and Genetics, Cyprus., Stefanou C; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus., Ljubanović DG; Department for Nephropathology and Electron microscopy, University of Zagreb, Croatia., Nikolaou G; Veterinary diagnostic laboratory, Vet ex Machina LTD, Nicosia, Cyprus., Borza DB; Dept. of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, TN, United States of America., Stylianou K; Department of Nephrology, University of Crete Medical School, Greece., Gross O; Clinic for Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany., Deltas C; Center of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus Medical School, Cyprus.

Publikováno v: Matrix biology plus [Matrix Biol Plus] 2020 Dec 30; Vol. 9, pp. 100053. Date of Electronic Publication: 2020 Dec 30 (Print Publication: 2021).