Zobrazeno 1 - 10
of 23
pro vyhledávání: '"AR binding"'
Autor:
Ju Guo, Zhao Wei, Tianwei Jia, Liyang Wang, Nuosu Nama, Jiaqian Liang, Xinghua Liao, Xiaming Liu, Yanfei Gao, Xiaoqiang Liu, Keshan Wang, Bin Fu, Shaoyong Shawn Chen
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Androgen receptor (AR) activation and repression dual-functionality only became known recently and still remains intriguing in prostate cancer (PCa). MYC is a prominent oncogene that functionally entangles with AR signaling in PCa
Externí odkaz:
https://doaj.org/article/b8dc90534bbf4665ae410b4fe0f9222d
Akademický článek
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Akademický článek
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Publikováno v:
SAR and QSAR in Environmental Research. 27:303-316
A fundamental element when deriving a robust and predictive in silico model is not only the statistical quality of the model in question but, equally important, the estimate of its predictive boundaries. This work presents a new method, conformal pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ebe8fad19d3113e6c40d69aa32c649
https://doi.org/10.1080/1062936x.2016.1172665
https://doi.org/10.1080/1062936x.2016.1172665
Publikováno v:
The Journal of Physical Chemistry A. 112:6074-6078
Recently, we reported the spectrum of Ar x D4HO2(+) [McCunn; et, al. J. Phys. Chem. B 2008, 112, 321], and here, we extend that work to include the Ar x H4DO2(+) isotopologue in order to explore why the Ar atom has a much greater propensity for attac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01e1bd7e18ba31196fa87de94791b18
https://doi.org/10.1021/jp802172q
https://doi.org/10.1021/jp802172q
Autor:
Heather H. Cheng, Bruce Montgomery
Publikováno v:
Management of Castration Resistant Prostate Cancer ISBN: 9781493911752
Androgen receptor (AR) signaling is critical in the development and progression of prostate cancer, and the AR signaling axis is a credentialed target in the treatment of prostate cancer. Greater insights into the biology of prostate cancer have reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87ac4a5fe7f4d353c4d58a63fb53ffd
https://doi.org/10.1007/978-1-4939-1176-9_5
https://doi.org/10.1007/978-1-4939-1176-9_5
Autor:
Keesook Lee, Chin-Hee Song, Hue Thi My Van, Daulat Bikram Khadka, Won-Jea Cho, Eun-Yeung Gong, Eunsook Park, Suhui Yang
Publikováno v:
Journal of medicinal chemistry. 56(8)
Molecular knowledge of pure antagonism and systematic SAR study offered a direction for structural optimization of DIMN to provide nicotinamides as a novel series of AR antagonists. Nicotinamides with extended linear scaffold bearing sterically bulky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cbb081648158762f0c8a66e282af91
https://pubmed.ncbi.nlm.nih.gov/23527816
https://pubmed.ncbi.nlm.nih.gov/23527816
Publikováno v:
Journal of chemical information and modeling. 52(8)
Tetrahydroquinolines (THQs), a new class of nonsteroidal selective androgen receptor (AR) modulators, have two indispensable functional groups, that is, a hydroxyl group for AR binding and a nitro group for agonistic activity. Interestingly, switchin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bb83b258d8d5354cb3e0113bbcb6c1
https://pubmed.ncbi.nlm.nih.gov/22794275
https://pubmed.ncbi.nlm.nih.gov/22794275
Autor:
Yong Woon Jung, Marcian E. Van Dort
Publikováno v:
ChemInform. 32
A series of arylhydantoin derivatives modeled after the antiandrogen RU 58841 was generated to identify potential candidates for development as androgen receptor (AR) radioligands. Side-chain modified derivatives of RU 58841, suitable for labeling wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::879a0dcc3ddb5d427da9e5d2ba5104be
https://doi.org/10.1002/chin.200132121
https://doi.org/10.1002/chin.200132121
Publikováno v:
SAR and QSAR in environmental research. 13(1)
The COREPA approach for identifying the COmmon REactivity PAttern of biologically similar chemicals was employed to upgrade the recently derived affinity pattern for high androgen receptor (AR) binding affinity. The training set consisted of 28 stero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6708bac611efbd89341a5c747adbd51f
https://pubmed.ncbi.nlm.nih.gov/12074381
https://pubmed.ncbi.nlm.nih.gov/12074381