Abstract P6-11-08: Safety and efficacy results from phase I study of BYL 719 plus nab-paclitaxel in HER 2 negative metastatic breast cancer

Autor: P Sharma, J Ward, AR Brown, JN Scott, C Lehn, Anne O'Dea, Andrew K. Godwin, Raymond P. Perez, Stephen K. Williamson, Greg Reed, Qamar J. Khan, S Lewis, Vandana G. Abramson, Takefumi Komiya, Ja De Jong

Publikováno v: Cancer Research. 77:P6-11

Introduction Mutations/deregulations in the phosphatidylinositol-3-kinase (PI3K) pathway are common in breast cancer, Inhibition of the PI3K pathway is recognized as a promising target for the treatment of breast cancer. Although taxanes are effectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4b3dc61ab7b2b56f8700f95c211921c
https://doi.org/10.1158/1538-7445.sabcs16-p6-11-08

Ferroptosis-disease perils and therapeutic promise.

Autor: Brown AR; Department of Biological Sciences, Columbia University, New York, NY, USA., Hirschhorn T; Department of Biological Sciences, Columbia University, New York, NY, USA., Stockwell BR; Department of Biological Sciences, Columbia University, New York, NY, USA.; Department of Chemistry, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Nov 22; Vol. 386 (6724), pp. 848-849. Date of Electronic Publication: 2024 Nov 21.

DHA supplementation for early preterm birth prevention: An application of Bayesian finite mixture models to adaptive clinical trial design optimization.

Autor: Shi X; Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: xshi2@kumc.edu., Wick JA; Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA., Christifano DN; Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, USA., Carlson SE; Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, USA., Brown AR; Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA., Mudaranthakam DP; Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA., Gajewski BJ; Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA.

Publikováno v: Contemporary clinical trials [Contemp Clin Trials] 2024 Sep; Vol. 144, pp. 107633. Date of Electronic Publication: 2024 Jul 14.

Ferroptosis in health and disease.

Autor: Berndt C; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Alborzinia H; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Amen VS; Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany., Ayton S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia., Barayeu U; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany; Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan., Bartelt A; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany., Bayir H; Department of Pediatrics, Columbia University, New York City, NY, USA., Bebber CM; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Birsoy K; Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA., Böttcher JP; Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany., Brabletz S; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Brabletz T; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Brown AR; Department of Biological Sciences, Columbia University, New York City, NY, USA., Brüne B; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., Bulli G; Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany., Bruneau A; Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany., Chen Q; College of Life Sciences, Nankai University, Tianjin, China., DeNicola GM; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA., Dick TP; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Distéfano A; Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina., Dixon SJ; Department of Biology, Stanford University, Stanford, CA, USA., Engler JB; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany., Esser-von Bieren J; Department of Immunobiology, Université de Lausanne, Switzerland., Fedorova M; Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany., Friedmann Angeli JP; Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany., Friese MA; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany., Fuhrmann DC; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., García-Sáez AJ; Institute for Genetics, CECAD, University of Cologne, Germany; Max Planck Institute of Biophysics, Frankfurt/Main, Germany., Garbowicz K; Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany., Götz M; Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center Munich, Germany., Gu W; Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Hammerich L; Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany., Hassannia B; Department of Biomedical Sciences, University of Antwerp, Belgium., Jiang X; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Jeridi A; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany, Member of the German Center for Lung Research (DZL)., Kang YP; College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Republic of Korea., Kagan VE; School of Public Health, University of Pittsburgh, PA, USA., Konrad DB; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Kotschi S; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Lei P; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Le Tertre M; Center for Translational Biomedical Iron Research, Heidelberg University, Germany., Lev S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Liang D; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Linkermann A; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA., Lohr C; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Lorenz S; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Methner A; Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany., Michalke B; Research Unit Analytical Biogeochemistry, Helmholtz Center Munich, Germany., Milton AV; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Min J; School of Medicine, Zhejiang University, Hangzhou, China., Mishima E; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Müller S; Cellular and Chemical Biology, Institut Curie, Paris, France., Motohashi H; Department of Gene Expression Regulation, Tohoku University, Sendai, Japan., Muckenthaler MU; Center for Translational Biomedical Iron Research, Heidelberg University, Germany., Murakami S; Department of Gene Expression Regulation, Tohoku University, Sendai, Japan., Olzmann JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA., Pagnussat G; Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina., Pan Z; School of Life Sciences, Westlake University, Hangzhou, China., Papagiannakopoulos T; Department of Pathology, Grossman School of Medicine, New York University, NY, USA., Pedrera Puentes L; Institute for Genetics, CECAD, University of Cologne, Germany., Pratt DA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada., Proneth B; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Ramsauer L; Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany., Rodriguez R; Cellular and Chemical Biology, Institut Curie, Paris, France., Saito Y; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan., Schmidt F; Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany., Schmitt C; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Schulze A; Division of Tumour Metabolism and Microenvironment, DKFZ Heidelberg and DKFZ-ZMBH Alliance, Heidelberg, Germany., Schwab A; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Schwantes A; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., Soula M; Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA., Spitzlberger B; Department of Immunobiology, Université de Lausanne, Switzerland; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Munich, Germany., Stockwell BR; Department of Biological Sciences, Columbia University, New York City, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Chemistry, Columbia University, New York, NY, USA., Thewes L; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Thorn-Seshold O; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Toyokuni S; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan; Center for Integrated Sciences of Low-temperature Plasma Core Research (iPlasma Core), Tokai National Higher Education and Research System, Nagoya, Japan., Tonnus W; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany., Trumpp A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany., Vandenabeele P; VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Vanden Berghe T; Department of Biomedical Sciences, University of Antwerp, Belgium; VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Venkataramani V; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Germany., Vogel FCE; Division of Tumour Metabolism and Microenvironment, DKFZ Heidelberg and DKFZ-ZMBH Alliance, Heidelberg, Germany., von Karstedt S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Germany., Wang F; School of Medicine, Zhejiang University, Hangzhou, China., Westermann F; Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany., Wientjens C; Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Germany., Wilhelm C; Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Germany., Wölk M; Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany., Wu K; Department of Pathology, Grossman School of Medicine, New York University, NY, USA., Yang X; Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Yu F; College of Life Sciences, Nankai University, Tianjin, China., Zou Y; School of Life Sciences, Westlake University, Hangzhou, China; Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany. Electronic address: marcus.conrad@helmholtz-muenchen.de.

Publikováno v: Redox biology [Redox Biol] 2024 Sep; Vol. 75, pp. 103211. Date of Electronic Publication: 2024 May 30.

Exploring perceptions of and decision-making about CFTR modulators.

Autor: Landess L; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Prieur MG; Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Brown AR; Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Dellon EP; University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Publikováno v: Pediatric pulmonology [Pediatr Pulmonol] 2024 Jun; Vol. 59 (6), pp. 1614-1621. Date of Electronic Publication: 2024 Mar 08.