A genome-wide meta-analysis of palmoplantar pustulosis implicates T H 2 responses and cigarette smoking in disease pathogenesis.

Autor: Hernandez-Cordero A; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, United Kingdom., Thomas L; Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, Trondheim, Norway; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway; BioCore-Bioinformatics Core Facility, NTNU-Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Smail A; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, United Kingdom., Lim ZQ; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, United Kingdom; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore., Saklatvala JR; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, United Kingdom., Chung R; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom., Curtis CJ; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom., Baum P; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany., Visvanathan S; Boehringer Ingelheim Pharmaceuticals, Ridgefield, Conn., Burden AD; School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom., Cooper HL; Portsmouth Dermatology Unit, Portsmouth Hospitals Trust, Portsmouth, United Kingdom., Dunnill G; Bristol Royal Infirmary, Bristol, United Kingdom., Griffiths CEM; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Department of Dermatology, King's College Hospital, King's College London, London, United Kingdom., Levell NJ; Norwich Medical School, University of East Anglia, Norwich, United Kingdom., Parslew R; Department of Dermatology, Royal Liverpool Hospitals, Liverpool, United Kingdom., Reynolds NJ; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle NIHR Biomedical Research Centre and the Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Wahie S; University Hospital of North Durham, Durham, United Kingdom; Darlington Memorial Hospital, Darlington, United Kingdom., Warren RB; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Dermatology Centre, Northern Care Alliance NHS Foundation Trust, Manchester, United Kingdom., Wright A; St Lukes Hospital, Bradford, United Kingdom; Centre for Skin Science, University of Bradford, Bradford, United Kingdom., Simpson M; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, United Kingdom., Hveem K; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway; Department of Innovation and Research, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Barker JN; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, United Kingdom., Dand N; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, United Kingdom., Løset M; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU-Norwegian University of Science and Technology, Trondheim, Norway; Department of Dermatology, Clinic of Orthopedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Smith CH; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, United Kingdom., Capon F; Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, United Kingdom. Electronic address: francesca.capon@kcl.ac.uk.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Sep; Vol. 154 (3), pp. 657-665.e9. Date of Electronic Publication: 2024 May 28.

Loss-of-function myeloperoxidase mutations are associated with increased neutrophil counts and pustular skin disease

Autor: Vergnano, Marta, Mockenhaupt, Maja, Benzian-Olsson, Natashia, Paulmann, Maren, Grys, Katarzyna, Mahil, Satveer K., Chaloner, Charlotte, Barbosa, Ines A., August, Suzannah, Burden, A. David, Choon, Siew-Eng, Cooper, Hywel, Navarini, Alex A., Reynolds, Nick J., Wahie, Shyamal, Warren, Richard B., Wright, Andrew, Huffmeier, Ulrike, Baum, Patrick, Visvanathan, Sudha, Barker, Jonathan N., Smith, Catherine H., Capon, Francesca, APRICOT and PLUM study team

The identification of disease alleles underlying human autoinflammatory diseases can provide important insights into the mechanisms that maintain neutrophil homeostasis. Here, we focused our attention on generalized pustular psoriasis (GPP), a potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b9a48a74c1cfc5df93f9da71d5d9b6ce
https://eprints.gla.ac.uk/224996/1/224996.pdf

Single-cell analysis implicates T H 17-to-T H 2 cell plasticity in the pathogenesis of palmoplantar pustulosis.

Autor: McCluskey D; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Benzian-Olsson N; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Mahil SK; St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Hassi NK; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Wohnhaas CT; Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany., Burden AD; Institute of Infection Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Griffiths CEM; Dermatology Centre, Salford Royal National Health Service (NHS) Foundation Trust, National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, University of Manchester, Manchester, United Kingdom., Ingram JR; Department of Dermatology, Division of Infection & Immunity, Cardiff University, Cardiff, United Kingdom., Levell NJ; Norwich Medical School, University of East Anglia, Norwich, United Kingdom., Parslew R; Department of Dermatology, Royal Liverpool Hospitals, Liverpool, United Kingdom., Pink AE; St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Reynolds NJ; Translational and Clinical Research Institute, Newcastle University and Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Warren RB; Dermatology Centre, Salford Royal National Health Service (NHS) Foundation Trust, National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, University of Manchester, Manchester, United Kingdom., Visvanathan S; Boehringer Ingelheim Pharmaceuticals, Ridgefield, Conn., Baum P; Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany., Barker JN; St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Smith CH; St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Capon F; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom. Electronic address: francesca.capon@kcl.ac.uk.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2022 Oct; Vol. 150 (4), pp. 882-893. Date of Electronic Publication: 2022 May 12.

Association of Clinical and Demographic Factors With the Severity of Palmoplantar Pustulosis.

Autor: Benzian-Olsson N; Department of Medical and Molecular Genetics, King's College London, London, United Kingdom., Dand N; Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.; Health Data Research UK, London, United Kingdom., Chaloner C; Department of Medical and Molecular Genetics, King's College London, London, United Kingdom., Bata-Csorgo Z; Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary., Borroni R; Humanitas Clinical and Research Center, IRCCS, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Burden AD; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Cooper HL; Portsmouth Dermatology Unit, Portsmouth Hospitals Trust, Portsmouth, United Kingdom., Cornelius V; Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, United Kingdom., Cro S; Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, United Kingdom., Dasandi T; St John's Institute of Dermatology, King's College London, London, United Kingdom., Griffiths CEM; Dermatology Centre, National Institute for Health Research Manchester Biomedical Research Centre, University of Manchester, Manchester, United Kingdom., Kingo K; Dermatology Clinic, Tartu University Hospital, Department of Dermatology, University of Tartu, Tartu, Estonia., Koks S; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch and Perron Institute for Neurological and Translational Science, Murdoch University, Nedlands, Western Australia, Australia., Lachmann H; National Amyloidosis Centre, University College London, Royal Free Campus, London, United Kingdom., McAteer H; The Psoriasis Association, Northampton, United Kingdom., Meynell F; St John's Institute of Dermatology, King's College London, London, United Kingdom., Mrowietz U; Psoriasis Center at the Department of Dermatology, University Medical Center, Schleswig-Holstein, Campus Kiel, Kiel, Germany., Parslew R; Department of Dermatology, Royal Liverpool Hospitals, Liverpool, United Kingdom., Patel P; St John's Institute of Dermatology, King's College London, London, United Kingdom., Pink AE; St John's Institute of Dermatology, King's College London, London, United Kingdom., Reynolds NJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Department of Dermatology and National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Tanew A; Department of Dermatology, Medical University of Vienna, Austria., Torz K; Psoriasis Center at the Department of Dermatology, University Medical Center, Schleswig-Holstein, Campus Kiel, Kiel, Germany., Trattner H; Department of Dermatology, Medical University of Vienna, Austria., Wahie S; Department of Dermatology, University Hospital of North Durham, Durham., Warren RB; The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom., Wright A; Department of Dermatology, St Lukes Hospital, Bradford, United Kingdom., Barker JN; St John's Institute of Dermatology, King's College London, London, United Kingdom., Navarini AA; Department of Dermatology & Allergy, University Hospital of Basel, Basel, Switzerland., Smith CH; St John's Institute of Dermatology, King's College London, London, United Kingdom., Capon F; Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.

Publikováno v: JAMA dermatology [JAMA Dermatol] 2020 Nov 01; Vol. 156 (11), pp. 1216-1222.

Palmoplantar pustulosis successfully treated with upadacitinib: Report of three cases.

Autor: Gaiani, Francesca Maria¹ (AUTHOR) fm.gaiani@gmail.com, Malagoli, Piergiorgio¹ (AUTHOR), Carrera, Carlo Giovanni² (AUTHOR)

Publikováno v: Australasian Journal of Dermatology. Nov2023, Vol. 64 Issue 4, p568-570. 3p.