Zobrazeno 1 - 10
of 93
pro vyhledávání: '"APPswe/PS1dE9 mice"'
Autor:
Xiangpei Yue, Yanzhao Zhou, Meng Qiao, Xingnan Zhao, Xin Huang, Tong Zhao, Xiang Cheng, Ming Fan, Yongqi Zhao, Ruoli Chen, Lingling Zhu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-16 (2021)
Abstract Background Alzheimer’s disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic tre
Externí odkaz:
https://doaj.org/article/ed26adcda63d4b01a593c7eb25408643
Autor:
Elena Sánchez-López, Miren Ettcheto, Maria Antonia Egea, Marta Espina, Amanda Cano, Ana Cristina Calpena, Antoni Camins, Nuria Carmona, Amélia M. Silva, Eliana B. Souto, Maria Luisa García
Publikováno v:
Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Memantine, drug approved for moderate to severe Alzheimer’s disease, has not shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution to increase drug’
Externí odkaz:
https://doaj.org/article/09b836cd23f64c6aa9ac7db605e7ce8a
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Aggregated amyloid-β protein (Aβ) and Aβ-induced neuronal apoptosis have been implicated as critical factors in the pathophysiology of Alzheimer’s disease (AD). Certain preclinical results have indicated that the increased accumulation of protei
Externí odkaz:
https://doaj.org/article/0af7e2f876c64e31a71634ff1aa13800
Akademický článek
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Publikováno v:
Journal of Alzheimer's disease 81(3), 855-869 (2021). doi:10.3233/JAD-201540
Transgenic mouse models serve a better understanding of Alzheimer’s disease (AD) pathogenesis and its consequences on neuronal function. Well-known and broadly used AD models are APPswe/PS1dE9 mice, which are able to reproduce features of amyloid-
Autor:
Eva Machová, Vladimír Rudajev, Helena Smyčková, Henna Koivisto, Heikki Tanila, Vladimír Doležal
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 1, Pp 27-35 (2010)
We investigated the functional characteristics of pre- and postsynaptic cholinergic transmission in APPswe/PS1dE9 double transgenic mice at a young age (7-10 weeks) before the onset of amyloid plaque formation and at adult age (5-6 months) at its ons
Externí odkaz:
https://doaj.org/article/7a87953ec4a14df6bc5ef8502288ddf6
Autor:
Lingling Zhu, Xiangpei Yue, Tong Zhao, Ruoli Chen, Xin Huang, Meng Qiao, Yong-Qi Zhao, Yanzhao Zhou, Ming Fan, Xiang Cheng, Xingnan Zhao
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-16 (2021)
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-16 (2021)
Background Alzheimer’s disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic treatment (I
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
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Autor:
Angela Kuhla, Claire Rühlmann, Tobias Lindner, Stefan Polei, Stefan Hadlich, Bernd J. Krause, Brigitte Vollmar, Stefan J. Teipel
Publikováno v:
NeuroImage : Clinical
NeuroImage: Clinical 15, 581-586 (2017). doi:10.1016/j.nicl.2017.06.009
NeuroImage: Clinical, Vol 15, Iss, Pp 581-586 (2017)
NeuroImage: Clinical 15, 581-586 (2017). doi:10.1016/j.nicl.2017.06.009
NeuroImage: Clinical, Vol 15, Iss, Pp 581-586 (2017)
Transgenic animal models of Aβ pathology provide mechanistic insight into some aspects of Alzheimer disease (AD) pathology related to Aβ accumulation. Quantitative neuroimaging is a possible aid to improve translation of mechanistic findings in tra