Zobrazeno 1 - 10
of 1 300
pro vyhledávání: '"APOL1"'
Autor:
Robert Greensmith, Isadora T Lape, Cristian V Riella, Alexander J Schubert, Jakob J Metzger, Anand S Dighe, Xiao Tan, Bernhard Hemmer, Josefine Rau, Sarah Wendlinger, Nora Diederich, Anja Schütz, Leonardo V Riella, Michael M Kaminski
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2619-2637 (2024)
Abstract Detecting genetic variants enables risk factor identification, disease screening, and initiation of preventative therapeutics. However, current methods, relying on hybridization or sequencing, are unsuitable for point-of-care settings. In co
Externí odkaz:
https://doaj.org/article/7d2bcb1444954a0f83178a79d9c91a0b
Autor:
Etienne Pays
Publikováno v:
Kidney and Dialysis, Vol 4, Iss 2, Pp 126-143 (2024)
Apolipoprotein L1 (APOL1) nephropathy results from several podocyte dysfunctions involving morphological and motility changes, mitochondrial perturbations, inflammatory stress, and alterations in cation channel activity. I propose that this phenotype
Externí odkaz:
https://doaj.org/article/92c74571453a4986868c26867744081a
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-5 (2024)
Abstract Apolipoprotein L1 (APOL1) coding variants, termed G1 and G2, are established genetic risk factors for a growing spectrum of diseases, including kidney disease, in individuals of African ancestry. Evidence suggests that the risk variants, whi
Externí odkaz:
https://doaj.org/article/f3d7aba5ebe942f1a8c292be8a665ce1
Publikováno v:
Glomerular Diseases, Vol 4, Iss 1, Pp 64-73 (2024)
Introduction: Toxic gain-of-function Apolipoprotein L1 (APOL1) variants contribute to the development of proteinuric nephropathies collectively referred to as APOL1-mediated kidney disease (AMKD). Despite standard-of-care treatments, patients with AM
Externí odkaz:
https://doaj.org/article/ac820546dd95449ba9f0f84a346c1604
Akademický článek
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Publikováno v:
Kidney Medicine, Vol 6, Iss 6, Pp 100828- (2024)
Rationale & Objective: The effect of apolipoprotein L1(APOL1) genotype on future risk of kidney disease among middle-aged individuals with good kidney function is not well established. Study Design: Longitudinal cohort study. Setting & Participants:
Externí odkaz:
https://doaj.org/article/97d762aca0424ce6b9ebd34a11062041
Autor:
Murat Dogan, Christine Watkins, Holly Ingram, Nicholas Moore, Grace M. Rucker, Elizabeth G. Gower, James D. Eason, Anshul Bhalla, Manish Talwar, Nosratollah Nezakatgoo, Corey Eymard, Ryan Helmick, Jason Vanatta, Amandeep Bajwa, Canan Kuscu, Cem Kuscu
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionApolipoprotein-L1 (APOL1) is a primate-specific protein component of high-density lipoprotein (HDL). Two variants of APOL1 (G1 and G2), provide resistance to parasitic infections in African Americans but are also implicated in kidney-rela
Externí odkaz:
https://doaj.org/article/90aa22aae60f4501bd8dd9857dc88b19
Autor:
Haibing Xiao, Yan Qu, Haolin Li, Yi Zhang, Mintian Fei, Chaozhao Liang, Hongmei Yang, Xiaoping Zhang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background The VHL-HIF pathway and lipid droplet accumulation are the main characteristics of clear cell renal cell carcinoma (ccRCC). However, the connection between the two features is largely unknown. Methods We used transcriptional seque
Externí odkaz:
https://doaj.org/article/1e8413fb65f84c90ae536528dee0d9de
Autor:
Carlos Eduardo Duran, Mayra Estacio, Daniela Espinosa, Eliana Manzi, Juan G. Posada, Liliana Mesa, Johanna Schweineberg
Publikováno v:
Kidney & Blood Pressure Research, Vol 48, Iss 1, Pp 785-790 (2023)
Introduction: The association of APOL1 risk variants with cardiovascular risk and cardiovascular disease (CVD) in observational and clinical trials has had inconsistent results. We aim to assess the relationship between the presence of APOL1 risk var
Externí odkaz:
https://doaj.org/article/77c694a7db2a419c85e20c2326192817
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA pr
Externí odkaz:
https://doaj.org/article/81c80291a7a54d09a7fae2be2dd5c2bf