Zobrazeno 1 - 10
of 1 518
pro vyhledávání: '"APOE4"'
Autor:
Qing Qi, Feng Deng, Rebecca Sammon, Karen Ritchie, Graciela Muniz-Terrera, Ivan Koychev, Paresh Malhotra, Siobhan Hutchinson, David Robinson, John T. O’Brien, Craig W. Ritchie, Brian Lawlor, Lorina Naci
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Females have a higher age-adjusted incidence of Alzheimer’s Disease (AD) than males, even when accounting for longer lifespan and, therefore, stand to benefit the most from dementia prevention efforts. As exposure to many modifi
Externí odkaz:
https://doaj.org/article/f444f2acc06b4074945bd1073a5c08c6
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-24 (2024)
Abstract Background Persistent innate and adaptive immune responses in the brain contribute to the progression of Alzheimer’s disease (AD). APOE4, the most important genetic risk factor for sporadic AD, encodes apolipoprotein E4, which by itself is
Externí odkaz:
https://doaj.org/article/14905b7d5e394e13a78759243af56b53
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-9 (2024)
Abstract Background Elevated concentrations of low-density lipoprotein cholesterol (LDL-C) are linked to dementia risk, and conversely, increased plasma concentrations of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein-A1 (Apo-A1) ass
Externí odkaz:
https://doaj.org/article/ef79d49c09a54c3b8ca6b95c8c59316c
Autor:
Musung Keum, Boung Chul Lee, Young Min Choe, Guk-Hee Suh, Shin Gyeom Kim, Hyun Soo Kim, Jaeuk Hwang, Dahyun Yi, Jee Wook Kim
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background This study investigated the correlation between protein intake and Alzheimer’s disease (AD)-related cognitive decline, particularly in episodic memory, among older adults without dementia. Furthermore, we assessed the moderating
Externí odkaz:
https://doaj.org/article/9e868bdfef9845e5b09c57413418aac9
Publikováno v:
Animal Models and Experimental Medicine, Vol 7, Iss 3, Pp 347-361 (2024)
Abstract Background Apolipoprotein E4 (ApoE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease, and it can aggravate depressive symptoms in non‐AD patients. However, the impact of ApoE4 on AD‐associated depression
Externí odkaz:
https://doaj.org/article/aafee32291554212bbe8b373ecb6376c
Autor:
Chelsea N. Johnson, Colton R. Lysaker, Colin S. McCoin, Mara R. Evans, John P. Thyfault, Heather M. Wilkins, Jill K. Morris, Paige C. Geiger
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionApolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele mediates risk. APOE4 carriers experience reduced mobility and faster decline in muscle strength, suggesting skel
Externí odkaz:
https://doaj.org/article/1c0e31187b6140b89fbbdc665d19fd12
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Externí odkaz:
https://doaj.org/article/07071b2f1b944a94845e46756033e5af
Autor:
Christian Behl
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The amyloid-cascade-hypothesis of the pathogenesis of Alzheimer’s disease (AD) was introduced 32 years ago, in 1992. From early on, this clear and straight forward hypothesis received a lot of attention, but also a lot of substantial criticism. For
Externí odkaz:
https://doaj.org/article/7a9a4ca2368d432485298b1084baf4c2
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain parenchyma and response to cues associated with damage. Aging and APOE4 genotype are the strongest risk factors for Alzheime
Externí odkaz:
https://doaj.org/article/7936248805824daca77f40ec975cc4d4
Autor:
Katrina A. Wugalter, Rachel A. Schroeder, Rebecca C. Thurston, Minjie Wu, Howard J. Aizenstein, Ann D. Cohen, M. Ilyas Kamboh, Thomas K. Karikari, Carol A. Derby, Pauline M. Maki
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
BackgroundWomen carrying the APOE4 allele are at greater risk of developing Alzheimer’s disease (AD) from ages 65–75 years compared to men. To better understand the elevated risk conferred by APOE4 carrier status among midlife women, we investiga
Externí odkaz:
https://doaj.org/article/1c84be78ffea4180a58e7ba1605e2a9f