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pro vyhledávání: '"APOE genotype"'
Akademický článek
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Autor:
Anna M. Chen, Martin Gajdošík, Wajiha Ahmed, Sinyeob Ahn, James S. Babb, Esther M. Blessing, Allal Boutajangout, Mony J. de Leon, Ludovic Debure, Naomi Gaggi, Mia Gajdošík, Ajax George, Mobeena Ghuman, Lidia Glodzik, Patrick Harvey, Christoph Juchem, Karyn Marsh, Rosemary Peralta, Henry Rusinek, Sulaiman Sheriff, Alok Vedvyas, Thomas Wisniewski, Helena Zheng, Ricardo Osorio, Ivan I. Kirov
Publikováno v:
NeuroImage, Vol 297, Iss , Pp 120742- (2024)
ABSTRACT: Purpose: The pathological hallmarks of Alzheimer's disease (AD), amyloid, tau, and associated neurodegeneration, are present in the cortical gray matter (GM) years before symptom onset, and at significantly greater levels in carriers of the
Externí odkaz:
https://doaj.org/article/df54edeec1d44a40b0c054d4676011a6
Autor:
Mingqing Zhao, Yuanjing Li, Xiaodong Han, Chunyan Li, Pin Wang, Jiafeng Wang, Tingting Hou, Yongxiang Wang, Lin Cong, Joanna M. Wardlaw, Lenore J. Launer, Lin Song, Yifeng Du, Chengxuan Qiu
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)
Abstract Introduction We sought to characterize cognitive profiles associated with enlarged perivascular spaces (EPVS) among Chinese older adults. Methods This population‐based study included 1191 dementia‐free participants (age ≥60 years) in t
Externí odkaz:
https://doaj.org/article/0df21ebd3cdb4709ae7e2d24e2df6101
Autor:
Shilna Azhuvalappil, Raghav Prasad, Pravin Sahadevan, Hitesh Pradhan, Pooja Rai, Jonas S. Sundarakumar
Publikováno v:
Metabolism Open, Vol 22, Iss , Pp 100281- (2024)
Background: Metabolic syndrome (MetS), characterized by elevated blood pressure, high blood glucose, excess abdominal fat, and abnormal cholesterol or triglyceride levels, significantly increases the risk of various non-communicable diseases. This st
Externí odkaz:
https://doaj.org/article/f746b1d347144ca993cec3e122ef6add
Autor:
Lei Guo, Jiqing Cao, Jianwei Hou, Yonghe Li, Min Huang, Li Zhu, Larry Zhang, Yeji Lee, Mariana Lemos Duarte, Xianxiao Zhou, Minghui Wang, Chia-Chen Liu, Yuka Martens, Michael Chao, Alison Goate, Guojun Bu, Vahram Haroutunian, Dongming Cai, Bin Zhang
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-25 (2023)
Abstract Background Alzheimer’s disease (AD) is a progressive and age-associated neurodegenerative disorder that affects women disproportionally. However, the underlying mechanisms are poorly characterized. Moreover, while the interplay between sex
Externí odkaz:
https://doaj.org/article/d883bf15b9474573b841d4c12f05c16a
Autor:
Jenna Najar, Valgeir Thorvaldsson, Silke Kern, Johan Skoog, Margda Waern, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Anna Zettergren
Publikováno v:
Neurobiology of Disease, Vol 189, Iss , Pp 106357- (2023)
Background: Polygenic risk scores for Alzheimer's disease (AD-PRSs) have been associated with cognition. However, few studies have examined the effect of AD-PRS beyond the APOE gene, and the influence of genetic variants related to level of cognitive
Externí odkaz:
https://doaj.org/article/1d6f3371074c4d0896cd0e15861ae4d1
Autor:
Corinne Pettigrew, Jurijs Nazarovs, Anja Soldan, Vikas Singh, Jiangxia Wang, Timothy Hohman, Logan Dumitrescu, Julia Libby, Brian Kunkle, Alden L. Gross, Sterling Johnson, Qiongshi Lu, Corinne Engelman, Colin L. Masters, Paul Maruff, Simon M. Laws, John C. Morris, Jason Hassenstab, Carlos Cruchaga, Susan M. Resnick, Melissa H. Kitner-Triolo, Yang An, Marilyn Albert
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Both Alzheimer’s disease (AD) genetic risk factors and indices of cognitive reserve (CR) influence risk of cognitive decline, but it remains unclear whether they interact. This study examined whether a CR index score modifies th
Externí odkaz:
https://doaj.org/article/6508cd9e34be4b1a9b73eff2a77da0cf
Autor:
Angelika Caputo, Amy Racine, Ines Paule, Pierre N. Tariot, Jessica B. Langbaum, Neva Coello, Marie-Emmanuelle Riviere, J. Michael Ryan, Cristina Lopez Lopez, Ana Graf, for the National Alzheimer’s Coordinating Center, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background There is a critical need for novel primary endpoints designed to detect early and subtle changes in cognition in clinical trials targeting the asymptomatic (preclinical) phase of Alzheimer’s disease (AD). The Alzheimer’s Preve
Externí odkaz:
https://doaj.org/article/b6f0a45931354595ad372db4809d8620
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Background Growing evidence has showed an association between habitual glucosamine use and type 2 diabetes (T2D). However, the effect of habitual glucosamine use on risk of dementia remains poorly understood. Our study aimed to examine the a
Externí odkaz:
https://doaj.org/article/d06705f3f05343b1a5b06880d4840252
Autor:
Jori Tomassen, Anouk den Braber, Sven J. van der Lee, Lianne M. Reus, Elles Konijnenberg, Stephen F. Carter, Maqsood Yaqub, Bart N.M. van Berckel, Lyduine E. Collij, Dorret I. Boomsma, Eco J.C. de Geus, Philip Scheltens, Karl Herholz, Betty M. Tijms, Pieter Jelle Visser
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background: What combination of risk factors for Alzheimer’s disease (AD) are most predictive of cognitive decline in cognitively unimpaired individuals remains largely unclear. We studied associations between APOE genotype, AD-Polygenic R
Externí odkaz:
https://doaj.org/article/de2470f34ab8427f961bab5f7eb68c5e