Apolipoprotein C3 is negatively associated with estrogen and mediates the protective effect of estrogen on hypertriglyceridemia in obese adults

Autor: Jinman Li, Honglin Sun, Ying Wang, Jia Liu, Guang Wang

Publikováno v: Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-9 (2023)

Abstract Background Both estrogen and apolipoprotein C3 (ApoC3) play crucial roles in lipid metabolism. But the link between them remains unclear, and it is unknown whether estrogen regulates triglyceride (TG) levels via ApoC3. Researchers hypothesiz

Externí odkaz: https://doaj.org/article/027112bf941641d3b1165838c05e95cf

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

Autor: Thimoteus Speer, Anna Paschen, Joachim Jankowski, David Schmit, Lucia Rohrer, Eicke Latz, Sarah Triem, Willi Jahnen-Dechent, Jochen Reiser, Vera Jankowski, Barbara A. Niemeyer, Gunter Aßmann, Gerhard M. Kostner, Michael D. Menger, Christina Körbel, Danilo Fliser, Stephen Zewinger, Susanne Schuster, Rafael Kramann, Michael Böhm, Simina-Ramona Selejan, Manfred Kopf, Winfried März, Ulrich Laufs, Dalia Alansary, Mira Klug, Eunsil Hahm, Tobias Herter, Günther Silbernagel, Robert Bals, Martina Sester, Urban Sester, Emmanuel Ampofo, Stefan J Schunk, Matthias W. Laschke

Publikováno v: Nature Immunology, 21(1), 30-+. Nature Publishing Group
Nature immunology 21(1), 30-41 (2019). doi:10.1038/s41590-019-0548-1
Nature Immunology, 21(1), 30-41. Nature Publishing Group

NLRP3-inflammasome-driven inflammation is involved in the pathogenesis of a variety of diseases. Identification of endogenous inflammasome activators is essential for the development of new anti-inflammatory treatment strategies. Here, we identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f4f8bbeae748a0cac86e45204497f6
https://cris.maastrichtuniversity.nl/en/publications/ebd63dda-1451-4416-9dff-90b522012719