Zobrazeno 1 - 10
of 945
pro vyhledávání: '"APOBEC3"'
Autor:
Maksim V. Kvach, Stefan Harjes, Harikrishnan M. Kurup, Geoffrey B. Jameson, Elena Harjes, Vyacheslav V. Filichev
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1088-1098 (2024)
Nucleoside and polynucleotide cytidine deaminases (CDAs), such as CDA and APOBEC3, share a similar mechanism of cytosine to uracil conversion. In 1984, phosphapyrimidine riboside was characterised as the most potent inhibitor of human CDA, but the qu
Externí odkaz:
https://doaj.org/article/3054820e05924e07b1987d9f1948b5dd
Autor:
Phelipe Magalhães Duarte, Ridwan Olamilekan Adesola, Swagatika Priyadarsini, Rohit Singh, Mohamed N.F. Shaheen, Oluwaseun Adeolu Ogundijo, Bashar Haruna Gulumbe, Mohamed Lounis, Mahmoud Samir, Karthikeyan Govindan, Odunola Sefiyat Adebiyi, Godfred Yawson Scott, Parsa Ahmadi, Vahid Mahmoodi, Hanie Chogan, Salim Gholami, Omid Shirazi, Shervin Khalilzadeh Moghadam, Niloofer Jafari, Fatemeh Shahabinejad, Kannan Subbaram, Mohamed Fawzy, Abdul Rehman, Sina Salajegheh Tazerji
Publikováno v:
The Microbe, Vol 4, Iss , Pp 100141- (2024)
Monkeypox, now named mpox, has emerged as a significant public threat, as evidenced by the 2022 outbreak affecting over seventy countries globally. This infectious disease presents debilitating symptoms, including painful skin rashes, mucosal lesions
Externí odkaz:
https://doaj.org/article/d2f30336ad4541dc8c60a6289aae609e
Autor:
Jiaying Shen, Xinxin Xu, Junyan Fan, Hongsen Chen, Yue Zhao, Weijin Huang, Wenbin Liu, Zihan Zhang, Qianqian Cui, Qianqian Li, Zheyun Niu, Dongming Jiang, Guangwen Cao
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32139- (2024)
SARS-CoV-2 evolves gradually to cause COVID-19 epidemic. One of driving forces of SARS-CoV-2 evolution might be activation of apolipoprotein B mRNA editing catalytic subunit-like protein 3 (APOBEC3) by inflammatory factors. Here, we aimed to elucidat
Externí odkaz:
https://doaj.org/article/3533df9087c044b99ef9d8c22c1e3b77
Autor:
MST Monira Begum, Ayub Bokani, Samiul Alam Rajib, Mohadeseh Soleimanpour, Yosuke Maeda, Kazuhisa Yoshimura, Yorifumi Satou, Diako Ebrahimi, Terumasa Ikeda
Publikováno v:
Viruses, Vol 16, Iss 7, p 1141 (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has acquired multiple mutations since its emergence. Analyses of the SARS-CoV-2 genomes from infected patients exhibit a bias toward C-to-U mutations, which are suggested to be caused by th
Externí odkaz:
https://doaj.org/article/1ee127e91c944350a970a5e9d6cd01ea
Autor:
Md Sakil Arman, Md Zafrul Hasan
Publikováno v:
Virus Research, Vol 341, Iss , Pp 199323- (2024)
Virion infectivity factor (Vif), an accessory protein of HIV-1 (human immunodeficiency virus type 1), antagonizes host APOBEC3 protein (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3) or A3 via proteasomal degradation, facilitating vir
Externí odkaz:
https://doaj.org/article/8033ec96590f46c8b3bc0306a3938796
Publikováno v:
Frontiers in Virology, Vol 4 (2024)
The human family of APOBEC3 enzymes are primarily studied as single-stranded DNA deoxycytidine deaminases that act as host restriction factors for a number of viruses and retroelements. The deamination of deoxycytidine to deoxyuridine causes inactiva
Externí odkaz:
https://doaj.org/article/ec2654d9a3f448b28b07d99a8fa9ea5d
Akademický článek
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Autor:
Michela Deiana, Denise Lavezzari, Antonio Mori, Silvia Accordini, Elena Pomari, Chiara Piubelli, Simone Malagò, Maddalena Cordioli, Niccolò Ronzoni, Andrea Angheben, Evelina Tacconelli, Maria Rosaria Capobianchi, Federico Giovanni Gobbi, Concetta Castilletti
Publikováno v:
Viruses, Vol 16, Iss 5, p 726 (2024)
In 2022, an unprecedented outbreak of mpox raged in several nations. Sequences from the 2022 outbreak reveal a higher nucleotide substitution if compared with the estimated rate for orthopoxviruses. Recently, intra-lesion SNVs (single nucleotide vari
Externí odkaz:
https://doaj.org/article/ffd1f0d3978e4870a5a05b1e8f12fc38
Autor:
Michael Jonathan, Terumasa Ikeda
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) family consists of cytosine deaminases implicated in diverse and important biological functions. APOBEC3 (A3) proteins belong to the APOBEC/AID family, and they catalyze the
Externí odkaz:
https://doaj.org/article/cec99a4848714854b29c4790ee1fba4c
Autor:
Terumasa Ikeda, Ryo Shimizu, Hesham Nasser, Michael A. Carpenter, Adam Z. Cheng, William L. Brown, Daniel Sauter, Reuben S. Harris
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+ T lymphocytes and macrophages. Previous studies have demonstrated that the apolipoprotein B mRNA editing enzyme polypeptide-like 3 (APOBEC3, A3) family of proteins
Externí odkaz:
https://doaj.org/article/3cc59ec71ecd4139a30a3d0bbeed458b