Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines

Autor: Yi Guo, Mingshi Yang, Li Zhang, Changzhi Shi, Dongmei Cun, Hriday Bera

Publikováno v: Acta Pharmaceutica Sinica. B
Guo, Y, Bera, H, Shi, C, Zhang, L, Cun, D & Yang, M 2021, ' Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines ', Acta Pharmaceutica Sinica B, vol. 11, no. 8, pp. 2565-2584 . https://doi.org/10.1016/j.apsb.2021.05.015
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2565-2584 (2021)

Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory infections, and systemic diseases such as diabetes. Most inhaled medicines c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ad93be5bd1dd39fb79dc4d37488c35
http://europepmc.org/articles/PMC8424368

Terahertz time-domain spectroscopy for powder compact porosity and pore shape measurements: An error analysis of the anisotropic bruggeman model

Autor: J. Axel Zeitler, Prince Bawuah, Moritz Anuschek

Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100079-(2021)
International Journal of Pharmaceutics: X

Terahertz time-domain spectroscopy (THz-TDS) is a novel technique which has been applied for pore structure analysis and porosity measurements. For this, mainly the anisotropic Bruggeman (AB-EMA) model is applied to correlate the effective refractive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715ba847e4448d1b028a59f009670918
http://www.sciencedirect.com/science/article/pii/S2590156721000086

Influence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary mixtures employing standard excipients

Autor: Bashar Ibraheem, Karl G. Wagner

Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100075-(2021)
International Journal of Pharmaceutics: X

Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and subsequently improvement of solubility when employed at unusual manufacturing proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c26bcf69ad09e72a26ff8a4321409b
http://www.sciencedirect.com/science/article/pii/S2590156721000049

The effect of inspiratory parameters after two separate inhalations on the dose emission of theophylline from low and high resistance dry powder inhalers

Autor: Hassane El Larhrib, Mohamad Abadelah, James J. Rooney, Jumannah Al-Assadi

Publikováno v: Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 28, Iss 1, Pp 74-86 (2020)

Graphical abstract
The dose emission from DPIs can be affected by the inspiratory parameters achieved by the patient as well as the device in-use. Conventional in-vitro dose emission methodology was used, but instead of using inhalation volume (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d7ca2879b8a4ec998280a2c65577f6
http://europepmc.org/articles/PMC6950967

The effects of pH, surfactant, ion concentration, coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals

Autor: Ren Shuzhen, Jianying Wang, Mingyu Liu, Chao Hong, Jiabin Sun, Guowen Li, Lei Zhang, Yan Xie

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 59-73 (2019)

Pharmaceutical cocrystals are a promising technology that can be used to improve the solubility of poor aqueous compounds. The objective of this study was to systematically investigate the solubility of myricetin (MYR) cocrystals, including their kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f02f7dbf542dcca93dd0cddc62e3dd0
https://doi.org/10.1016/j.apsb.2018.09.008