The CHEK2 variant C.349A>G is associated with prostate cancer risk and carriers share a common ancestor

Autor: Manuela Gago-Dominguez, Karina Dalsgaard Sørensen, Radka Kaneva, Canary Pass Investigators, Rosalind A. Eeles, Stella Koutros, Kim De Ruyck, Sonja I. Berndt, Manolis Kogevinas, Sofia Maia, Eli Marie Grindedal, Christopher J. Logothetis, Davor Lessel, Nora Pashayan, Ana Peixoto, Catarina Santos, Nawaid Usmani, Zsofia Kote-Jarai, Olivier Cussenot, Esther M. John, Christopher A. Haiman, Catherine M. Tangen, Jong Y. Park, Lorelei A. Mucci, Johanna Schleutker, Ruth C. Travis, Andreia Brandão, Sune F. Nielsen, Manuel R. Teixeira, Melissa C. Southey, Ana Vega, Adam S. Kibel, Ying Wang, Børge G. Nordestgaard, Cezary Cybulski, Jyotsna Batra, Kenneth Muir, Henrik Grönberg, Janet L. Stanford, Lisa F. Newcomb, Hermann Brenner, Manuela Pinheiro, Apcb BioResource, David E. Neal, Marta Cardoso, Paula Paulo, Barry S. Rosenstein, Monique J. Roobol, Robert J. Hamilton, Catharine M L West, Frank Claessens, Paul A. Townsend, Kathryn L. Penney, Susan L. Neuhausen, Alicja Wolk, Christiane Maier, Demetrius Albanes, Fredrik Wiklund, Maria P. Silva, Azad Hassan Abdul Razack, Sue A. Ingles

Publikováno v: Brandão, A, Paulo, P, Maia, S, Pinheiro, M, Peixoto, A, Cardoso, M, Silva, M P, Santos, C, Eeles, R A, Kote-Jarai, Z, Muir, K, Ukgpcs Collaborators, Schleutker, J, Wang, Y, Pashayan, N, Batra, J, Apcb BioResource, Grönberg, H, Neal, D E, Nordestgaard, B G, Tangen, C M, Southey, M C, Wolk, A, Albanes, D, Haiman, C A, Travis, R C, Stanford, J L, Mucci, L A, West, C M L, Nielsen, S F, Kibel, A S, Cussenot, O, Berndt, S I, Koutros, S, Sørensen, K D, Cybulski, C, Grindedal, E M, Park, J Y, Ingles, S A, Maier, C, Hamilton, R J, Rosenstein, B S, Vega, A, Kogevinas, M, Wiklund, F, Penney, K L, Brenner, H, John, E M, Kaneva, R, The Profile Study Steering Committee, The Impact Study Steering Committee And Collaborators & The PRACTICAL Consortium 2020, ' The CHEK2 Variant C.349A >G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor ', Cancers, vol. 12, no. 11 . https://doi.org/10.3390/cancers12113254
Cancers, 12(11):3254, 1-17. Multidisciplinary Digital Publishing Institute (MDPI)
Brandão, A, Paulo, P, Maia, S, Pinheiro, M, Peixoto, A, Cardoso, M, Silva, M P, Santos, C, Eeles, R A, Kote-Jarai, Z, Muir, K, Schleutker, J, Wang, Y, Pashayan, N, Batra, J, Grönberg, H, Neal, D E, Nordestgaard, B G, Tangen, C M, Southey, M C, Wolk, A, Albanes, D, Haiman, C A, Travis, R C, Stanford, J L, Mucci, L A, West, C M L, Nielsen, S F, Kibel, A S, Cussenot, O, Berndt, S I, Koutros, S, Sørensen, K D, Cybulski, C, Grindedal, E M, Park, J Y, Ingles, S A, Maier, C, Hamilton, R J, Rosenstein, B S, Vega, A, Kogevinas, M, Wiklund, F, Penney, K L, Brenner, H, John, E M, Kaneva, R, Logothetis, C J, Neuhausen, S L, De Ruyck, K, UKGPCS Collaborators, The Profile Study Steering Committee & The Practical Consortium 2020, ' The CHEK2 variant C.349A >G is associated with prostate cancer risk and carriers share a common ancestor ', Cancers, vol. 12, no. 11, 3254, pp. 1-17 . https://doi.org/10.3390/cancers12113254
Brandão, A, Paulo, P, Maia, S, Pinheiro, M, Peixoto, A, Cardoso, M, Silva, M P, Santos, C, Eeles, R A, Kote-Jarai, Z, Muir, K, Ukgpcs Collaborators, Schleutker, J, Wang, Y, Pashayan, N, Batra, J, Apcb BioResource, Grönberg, H, Neal, D E, Nordestgaard, B G, Tangen, C M, Southey, M C, Wolk, A, Albanes, D, Haiman, C A, Travis, R C, Stanford, J L, Mucci, L A, West, C M L, Nielsen, S F, Kibel, A S, Cussenot, O, Berndt, S I, Koutros, S, Sørensen, K D, Cybulski, C, Grindedal, E M, Park, J Y, Ingles, S A, Maier, C, Hamilton, R J, Rosenstein, B S, Vega, A, The Impact Study Steering Committee And Collaborators, Kogevinas, M, Wiklund, F, Penney, K L, Brenner, H, John, E M, Kaneva, R, Logothetis, C J, Neuhausen, S L, Ruyck, K D, Razack, A, Newcomb, L F, Canary Pass Investigators, Lessel, D, Usmani, N, Claessens, F, Gago-Dominguez, M, Townsend, P A, Roobol, M J, The Profile Study Steering Committee, The Practical Consortium & Teixeira, M R 2020, ' The CHEK2 Variant C.349A >G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor ', Cancers, vol. 12, no. 11, 3254, pp. 1-17 . https://doi.org/10.3390/cancers12113254
Cancers, Vol 12, Iss 3254, p 3254 (2020)

The identification of recurrent founder variants in cancer predisposing genes may have important implications for implementing cost-effective targeted genetic screening strategies. In this study, we evaluated the prevalence and relative risk of the C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa7e985f8a0fe4e419e9f130d57a7a2
https://pure.eur.nl/en/publications/26a68a81-047d-4d67-8d2b-5cb1b3b826ca

Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer

Autor: Karunamuni, Roshan A, Huynh-Le, Minh-Phuong, Fan, Chun C, Thompson, Wesley, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth, Lophatananon, Artitaya, UKGPCS collaborators, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, APCB BioResource (Australian Prostate Cancer BioResource), Grönberg, Henrik, Walsh, Eleanor I, Turner, Emma L, Lane, Athene, Martin, Richard M, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Nordestgaard, Børge G, Tangen, Catherine M, MacInnis, Robert J, Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A, Travis, Ruth C, Stanford, Janet L, Mucci, Lorelei A, West, Catharine ML, Nielsen, Sune F, Kibel, Adam S, Wiklund, Fredrik, Cussenot, Olivier, Berndt, Sonja I, Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Park, Jong Y, Ingles, Sue A, Maier, Christiane, Hamilton, Robert J, Rosenstein, Barry S, Vega, Ana, IMPACT Study Steering Committee and Collaborators, Kogevinas, Manolis, Penney, Kathryn L, Teixeira, Manuel R, Brenner, Hermann, John, Esther M, Kaneva, Radka, Logothetis, Christopher J, Neuhausen, Susan L, Razack, Azad, Newcomb, Lisa F, Canary PASS Investigators, Gamulin, Marija, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A, Roobol, Monique J, Zheng, Wei, Profile Study Steering Committee, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, Seibert, Tyler M, PRACTICAL Consortium

Publikováno v: Prostate cancer and prostatic diseases, vol 24, iss 2

BackgroundPolygenic hazard scores (PHS) can identify individuals with increased risk of prostate cancer. We estimated the benefit of additional SNPs on performance of a previously validated PHS (PHS46).Materials and method180 SNPs, shown to be previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4e963e330b57cf89dda5bd1bde2ea1f3
https://escholarship.org/uc/item/8mn2q2cr

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

The

Autor: Andreia, Brandão, Paula, Paulo, Sofia, Maia, Manuela, Pinheiro, Ana, Peixoto, Marta, Cardoso, Maria P, Silva, Catarina, Santos, Rosalind A, Eeles, Zsofia, Kote-Jarai, Kenneth, Muir, Ukgpcs Collaborators, Johanna, Schleutker, Ying, Wang, Nora, Pashayan, Jyotsna, Batra, Apcb BioResource, Henrik, Grönberg, David E, Neal, Børge G, Nordestgaard, Catherine M, Tangen, Melissa C, Southey, Alicja, Wolk, Demetrius, Albanes, Christopher A, Haiman, Ruth C, Travis, Janet L, Stanford, Lorelei A, Mucci, Catharine M L, West, Sune F, Nielsen, Adam S, Kibel, Olivier, Cussenot, Sonja I, Berndt, Stella, Koutros, Karina Dalsgaard, Sørensen, Cezary, Cybulski, Eli Marie, Grindedal, Jong Y, Park, Sue A, Ingles, Christiane, Maier, Robert J, Hamilton, Barry S, Rosenstein, Ana, Vega, The Impact Study Steering Committee And Collaborators, Manolis, Kogevinas, Fredrik, Wiklund, Kathryn L, Penney, Hermann, Brenner, Esther M, John, Radka, Kaneva, Christopher J, Logothetis, Susan L, Neuhausen, Kim De, Ruyck, Azad, Razack, Lisa F, Newcomb, Canary Pass Investigators, Davor, Lessel, Nawaid, Usmani, Frank, Claessens, Manuela, Gago-Dominguez, Paul A, Townsend, Monique J, Roobol, The Profile Study Steering Committee, The Practical Consortium, Manuel R, Teixeira

Publikováno v: Cancers

Simple Summary It is well-recognised the strong contribution of genetic factors to prostate cancer (PrCa) susceptibility, thus genetic screening is critical for presymptomatic diagnosis and identification of individuals at high-risk. In this context,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccce8dd675a598947a755115cb56412e
https://pubmed.ncbi.nlm.nih.gov/33158149

Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium

Autor: Lophatananon, Artitaya, Stewart-Brown, Sarah, Kote-Jarai, Zsofia, Olama, Ali Amin Al, Garcia, Sara Benlloch, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Giles, Graham G, Fitzgerald, Liesel M, Southey, Melissa C, Pharoah, Paul, Pashayan, Nora, Gronberg, Henrik, Wiklund, Fredrik, Aly, Markus, Stanford, Janet L, Brenner, Hermann, Dieffenbach, Aida K, Arndt, Volker, Park, Jong Y, Lin, Hui-Yi, Sellers, Thomas, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Batra, Jyotsna, Spurdle, Amanda, Clements, Judith A, APCB BioResource, PRACTICAL Consortium, Easton, Douglas, Eeles, Rosalind A, Muir, Kenneth

BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. METHODS: We analysed data from the PRACTICAL conso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4f3bd503fbe2b5172f08873b36bec4