Zobrazeno 1 - 10
of 140
pro vyhledávání: '"APC, antigen presenting cell"'
Autor:
Stephen J. Thomas, John L. Perez, Stephen P. Lockhart, Subramanian Hariharan, Nicholas Kitchin, Ruth Bailey, Katherine Liau, Eleni Lagkadinou, Özlem Türeci, Ugur Şahin, Xia Xu, Kenneth Koury, Samuel S. Dychter, Claire Lu, Teresa C. Gentile, William C. Gruber
Publikováno v:
Vaccine
Introduction Individuals with an underlying malignancy have high risk of poor COVID-19 outcomes. In clinical trials, COVID-19 vaccines were safe and efficacious against infection, hospitalization, and death, but most trials excluded participants with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb5f1adc9988d2825bb0d5a9ad1defc
https://doi.org/10.1016/j.vaccine.2021.12.046
https://doi.org/10.1016/j.vaccine.2021.12.046
Autor:
Haibo Cheng, Zhigui Wu, Jian Gao, Manru Li, Hongqi Chen, Dongdong Sun, Rui Zhang, Yuxian Shen, Qiang Xu, Xianjia Qi, Yang Sun, Mingxia Zhao, Dijun Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 149-166 (2022)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79268ea53d1ac127b470be7ad862d9e6
http://www.sciencedirect.com/science/article/pii/S2211383521002963
http://www.sciencedirect.com/science/article/pii/S2211383521002963
Publikováno v:
Advanced Drug Delivery Reviews
mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology, and nanotechnology have generated interest in delivering safe and effective mRNA th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0f88a1e945504ba8b4af825e8da083
https://doi.org/10.1016/j.addr.2020.12.014
https://doi.org/10.1016/j.addr.2020.12.014
Autor:
Karen A. Simmons, Li Luo, Erica J. Dashner-Titus, Debra MacKenzie, Laurie G. Hudson, Jodi R. Schilz
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 1917-1929 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Uranium and arsenic co-occur as contaminants in water sources in the Southwestern US. • Exposure to metals may alter gene expression and cause immune dysregulation in CD4+ T-cells. • RNA-seq analysis on CD4+
Highlights • Uranium and arsenic co-occur as contaminants in water sources in the Southwestern US. • Exposure to metals may alter gene expression and cause immune dysregulation in CD4+ T-cells. • RNA-seq analysis on CD4+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02ed1fd8c3c4023146cd14f108fc58a
https://doi.org/10.1016/j.toxrep.2021.11.019
https://doi.org/10.1016/j.toxrep.2021.11.019
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 315-329 (2021)
Computational and Structural Biotechnology Journal, 19
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 315-329 (2021)
Computational and Structural Biotechnology Journal, 19
Biotherapeutics, and antimicrobial proteins in particular, are of increasing interest for human medicine. An important challenge in the development of such therapeutics is their potential immunogenicity, which can induce production of anti-drug-antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc6eb34d6710e1da9ae4b3df006a799
https://doi.org/10.1016/j.csbj.2020.12.024
https://doi.org/10.1016/j.csbj.2020.12.024
Publikováno v:
Advanced Drug Delivery Reviews
With the COVID-19 pandemic now ongoing for close to a year, people all over the world are still waiting for a vaccine to become available. The initial focus of accelerated global research and development efforts to bring a vaccine to market as soon a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc05cf6e45db923a4422845905a5a74f
http://europepmc.org/articles/PMC7788321
http://europepmc.org/articles/PMC7788321
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Celiac disease (CD) is a common autoimmune disorder triggered by the ingestion of gluten in genetically susceptible individuals. Although the mechanisms underlying gliadin-mediated activation of adaptive immunity in CD have been well-characterized, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e702a75de5957371ae55d9bcbdb2bcd7
https://doi.org/10.1016/j.jcmgh.2020.12.002
https://doi.org/10.1016/j.jcmgh.2020.12.002
Autor:
Xiaohui Pan, Bo Yang, Hongjie Guo, Shuyuan Cheng, Xi Chen, Ling Ding, Qiaojun He, Wenxin Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 723-733 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Immunotherapy strategies targeting the programmed cell death ligand 1 (PD-L1)/programmed cell death 1 (PD-1) pathway in clinical treatments have achieved remarkable success in treating multiple types of cancer. However, owing to the heterogeneity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca7b0479f6fea7a89a3e1eb06905c5
https://doi.org/10.1016/j.apsb.2019.09.006
https://doi.org/10.1016/j.apsb.2019.09.006
Autor:
Christine P. Petersen, Kevin A. Bockerstett, Richard J. DiPaolo, Christine N. Noto, Ryan M. Teague, Lindsey M. Kuehm, Eric L. Ford, Jason C. Mills, James R. Goldenring, Chun Fung Wong
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 561-579 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 561-579 (2020)
Background & Aims The association between chronic inflammation and gastric carcinogenesis is well established, but it is not clear how immune cells and cytokines regulate this process. We investigated the role of interleukin 27 (IL27) in the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5944bc3c0b7785e1a2d843431f7bb28f
http://europepmc.org/articles/PMC7399182
http://europepmc.org/articles/PMC7399182
Autor:
Shaghayegh Haghjooy Javanmard, Abbas Alibakhshi, Elmira Mohammadi, Sahar Esfandyari, Leila Beikmohammadi, Samira Bahrami, Mohammad Mehdi Ranjbar, Shahrzad Ahangarzadeh, Fatemeh Mahmoudian, Kiana Shahzamani
Publikováno v:
International Immunopharmacology
COVID-19 is still a deadly disease that remains yet a major challenge for humans. In recent times, many large pharmaceutical and non-pharmaceutical companies have invested a lot of time and cost in fighting this disease. In this regard, today's scien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c9be9438e08539da23317f11ef7827
http://www.scopus.com/inward/record.url?scp=85113388882&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85113388882&partnerID=8YFLogxK