Zobrazeno 1 - 10
of 72
pro vyhledávání: '"APC, Adenomatous Polyposis Coli"'
Autor:
Jyotsna D. Godavarthi, Shahrazad Polk, Lisa Nunez, Amruthesh Shivachar, Nancy L. Glenn Griesinger, Angabin Matin
Publikováno v:
Biology, Vol 9, Iss 11, p 398 (2020)
Background: Splicing factor 1 (SF1) is a conserved alternative splicing factor expressed in many different mammalian cell types. The genetically modified Sf1+/− (or Sf1β-geo/+) mice express reduced levels of SF1 protein in mouse tissues, including
Externí odkaz:
https://doaj.org/article/79bc1fd9c8b24dddbd78cf8d170137e8
Autor:
Rakesh Mishra, Abdul Quaiyoom Khan, Rehan Khan, Anas Ahmad, Muneeb U. Rehman, Akshay Vyawahare, Ashok Kumar, Wajhul Qamar
Publikováno v:
Saudi Pharmaceutical Journal, Vol 27, Iss 8, Pp 1113-1126 (2019)
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal : SPJ
Graphical abstract
Cancer remains the topmost disorders of the mankind and number of cases is unceasingly growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the largest market in the modern treatment of cance
Cancer remains the topmost disorders of the mankind and number of cases is unceasingly growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the largest market in the modern treatment of cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c3f982c7088407eff18e6c8b9dcfe0
http://www.sciencedirect.com/science/article/pii/S1319016419301227
http://www.sciencedirect.com/science/article/pii/S1319016419301227
Autor:
Anagha Krishna, Thaddeus S. Stappenbeck, Xiaohua Jin, Ron Bose, Elisa M. Murray, Takahiro E. Ohara, Xiaoqing Cheng
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1105-1120 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1105-1120 (2021)
Background and Aims The Cancer Genome Atlas (TCGA) project has identified HER2 mutations or amplification in 7% of colon cancers. In addition to HER2 mutations, colon cancer patients also possess co-occurring mutations in genes such as APC. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6ffa0c444bfacb709541dc4fc8a4d5
http://europepmc.org/articles/PMC8350008
http://europepmc.org/articles/PMC8350008
Autor:
Mingfei Ji, Jie Chen, Chuan Lv, Xinyi Li, Zongtao Chai, Jun Pu, Yuran Qiu, Duan Ni, Jian Zhang, Yuanhao Wang, Shaoyong Lu
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3433-3446 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3433-3446 (2021)
RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301d6dec04ce4d283571a3cfb861136b
http://europepmc.org/articles/PMC8642438
http://europepmc.org/articles/PMC8642438
Autor:
Wolfgang Walther, Annika Wulf-Goldenberg, Ulrike Stein, Johannes Merk, Iduna Fichtner, Keziban M. Alp, Giannino Patone, Tamara Kanashova, Christine Sers, Philipp Mertins, Maria Rivera, Jens Hoffmann
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 21-35 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 21-35 (2021)
Patient-derived xenograft (PDX) tumor models represent a valuable platform for identifying new biomarkers and novel targets, to evaluate therapy response and resistance mechanisms. This study aimed at establishment, characterization and therapy testi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8082ec6c5f41c16d128a521a50759417
https://doi.org/10.1016/j.neo.2020.11.005
https://doi.org/10.1016/j.neo.2020.11.005
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 491-506 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in colorectal cancer (CRC) development, although they are implicated in the modulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7a306ac692719a8347e0c547725351
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
Akademický článek
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Autor:
Lisa Nunez, Nancy L Glenn Griesinger, Angabin Matin, Shahrazad Polk, Amruthesh C. Shivachar, Jyotsna D. Godavarthi
Publikováno v:
Biology
Volume 9
Issue 11
Biology, Vol 9, Iss 398, p 398 (2020)
Volume 9
Issue 11
Biology, Vol 9, Iss 398, p 398 (2020)
Background: Splicing factor 1 (SF1) is a conserved alternative splicing factor expressed in many different mammalian cell types. The genetically modified Sf1+/&minus
(or Sf1&beta
geo/+) mice express reduced levels of SF1 protein in mouse ti
(or Sf1&beta
geo/+) mice express reduced levels of SF1 protein in mouse ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1644f5b570f7406ceddb395f4c7c32c7
Publikováno v:
The Journal of Biological Chemistry
The ClC-2 chloride channel is expressed in the plasma membrane of almost all mammalian cells. Mutations that cause the loss of ClC-2 function lead to retinal and testicular degeneration and leukodystrophy, whereas gain-of-function mutations cause hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47630be6ad75ea242d49b9bd44693d8b
http://europepmc.org/articles/PMC7949093
http://europepmc.org/articles/PMC7949093
Autor:
Bénédicte Brulin, Unmesh Jadhav, Philippe Crespy, Zeinab Homayed, Jihane Boubaker-Vitre, Fanny Grillet, J. Hazerbroucq, Frédéric Hollande, Cyril Breuker, Julie Giraud, Christine Pignodel, J-F. Bourgaux, Ramesh A. Shivdasani, Philippe Jay, Julie Pannequin, Momeneh Foroutan
Publikováno v:
Translational Oncology
Translational Oncology, 2020, 14 (2), pp.101001. ⟨10.1016/j.tranon.2020.101001⟩
Translational Oncology, Vol 14, Iss 2, Pp 101001-(2021)
Translational Oncology, Elsevier, 2020, 14 (2), pp.101001. ⟨10.1016/j.tranon.2020.101001⟩
Translational Oncology, 2020, 14 (2), pp.101001. ⟨10.1016/j.tranon.2020.101001⟩
Translational Oncology, Vol 14, Iss 2, Pp 101001-(2021)
Translational Oncology, Elsevier, 2020, 14 (2), pp.101001. ⟨10.1016/j.tranon.2020.101001⟩
Highlights • Secretion of progastrin is a signature event of early malignant transformation in the colon. • In the healthy epithelium, progastrin is produced by a subset of enteroendocrine cells expressing both Bmi1 and Prox1. • LGR5-high intes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edac14cd110ff4d56111788f49ee3dd
https://hal.science/hal-03090781
https://hal.science/hal-03090781
