Zobrazeno 1 - 10
of 33
pro vyhledávání: '"APBB2"'
Publikováno v:
Aging (Albany NY)
Background: There is a well-established relationship between cell cycle progression and the development of stomach adenocarcinoma. This study aimed to elucidate the molecular mechanism and biological function of APBB2 in gastric cancer. Methods: Gast
Publikováno v:
Curr Opin Psychol
Opioid use disorder (OUD) affects millions of people worldwide and the risk of developing the disorder has a significant genetic component according to twin and family studies. Identification of the genetic variants underlying this inherited risk has
Autor:
Larissa Kägi, Uwe Konietzko, Sabine Probst, Maik Krüger, Daniel Schuppli, Roger M. Nitsch, Sarina Thöni
Publikováno v:
Journal of Cell Science.
The amyloid precursor protein (APP), a central molecule in Alzheimer's disease (AD), has physiological roles in cell adhesion and signaling, migration, neurite outgrowth and synaptogenesis. Intracellular adapter proteins mediate the function of trans
Akademický článek
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Autor:
Chiu-Ping Fang, Yu-Li Liu, Sheng-Chang Wang, Shu Chi Liu, Hsiang-Wei Kuo, Chia-Chen Liu, Andrew C.H. Chen, Tung-Hsia Liu
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 83
APBB2, amyloid beta (A4) precursor protein-binding family B member 2, has been reported to be associated with opioid dependence. In this study, we reported the first time that the genetic variants in the APBB2 gene were associated with use of ampheta
Publikováno v:
Genomics. 111(3)
A major obstacle in the treatment of human immunodeficiency virus type 1 (HIV-1) is its ability to establish latent infection. To find novel biomarkers associated with the mechanism of HIV-1 latent infection, we identified 70 candidate genes in HIV-1
Akademický článek
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Publikováno v:
Parkinsonism & Related Disorders. 15:525-531
Numerous studies have shown that the microtubule-associated protein tau (Mapt) gene plays an important role in tauopathies. However, little is known about the genetic regulatory network. In this study, we combined array analysis and quantitative trai
Autor:
Tricia A. Thornton-Wells, Lori B. Chibnik, Julie A. Schneider, Timothy J. Hohman, Angela L. Jefferson, David A. Bennett, William S. Bush, Phillip L. De Jaeger
Publikováno v:
Neurotoxicity research. 28(3)
Glyocogen synthase kinase 3 (GSK3) plays an important role in the pathophysiology of Alzheimer’s disease (AD) through the phosphorylation of tau. Recent work has suggested that GSK3β also plays a role in the amyloid pathway of AD through genetic i
Autor:
Pamela Moore, John Hardy, Ryan van Luchene, Kit Lau, Julie Williams, Catherine Foy, Simon Lovestone, Joseph J. Cantanese, Petra Nowotny, Nicola Archer, Lisa Doil, John C. Morris, John J. Sninsky, John Powell, Kristina Tacey, Andrew Grupe, Veronica Garcia, Michael Conlon O'Donovan, Leon J. Thal, Michael John Owen, Alison Goate, Charles M. Rowland, Paul Hollingworth, Peter Holmans, Yonghong Li
Publikováno v:
Human Mutation. 25:270-277
Alzheimer disease (AD) is a complex neurodegenerative disorder predisposed by multiple genetic factors. Mutations in amyloid beta precursor protein (APP) are known to be associated with autosomal dominant, early onset familial AD and possibly also la