Zobrazeno 1 - 10
of 661
pro vyhledávání: '"APAF1"'
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 17, Pp 1635-1649 (2024)
Yuanyuan Ding,* Linjiang Chen,* Jing Xu, Yuhan Feng, Qiong Liu Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China*These authors contributed equally to th
Externí odkaz:
https://doaj.org/article/42dc0ca75fb34b578ea18dd3647e213c
Autor:
Qiang Wang, Chen Chen, Xiao Xu, Chuanjun Shu, Changchang Cao, Zhangding Wang, Yao Fu, Lei Xu, Kaiyue Xu, Jiawen Xu, Anliang Xia, Bo Wang, Guifang Xu, Xiaoping Zou, Ruibao Su, Wei Kang, Yuanchao Xue, Ran Mo, Beicheng Sun, Shouyu Wang
Publikováno v:
Advanced Science, Vol 9, Iss 28, Pp n/a-n/a (2022)
Abstract Chemotherapeutics remain the first choice for advanced gastric cancers (GCs). However, drug resistance and unavoidable severe toxicity lead to chemotherapy failure and poor prognosis. Long noncoding RNAs (lncRNAs) play critical roles in tumo
Externí odkaz:
https://doaj.org/article/d309db78ae3f4aacbdd804d62e013a10
Publikováno v:
Journal of Occupational Medicine and Toxicology, Vol 16, Iss 1, Pp 1-13 (2021)
Abstract Background Pesticide residues in food and environment along with airborne contaminants such as endotoxins pose health risk. Although herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) has been associated with increased risk of lung cancers suc
Externí odkaz:
https://doaj.org/article/cfe10a0ba1b64f629cb56bef7f1266b7
Autor:
Huizhe Wu, Xiaoyun Hu, Yalun Li, Qiuchen Chen, Tong Sun, Yun Qiao, Wenyan Qin, Zhikun Wu, Boshi Fu, Haishan Zhao, Rui Zhang, Minjie Wei
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 764-779 (2020)
A growing number of studies have focused on the involvement of non-coding RNAs (ncRNAs) in the internal ribosome entry site (IRES)-mediated translation in tumorigenesis; however, the underlying mechanisms in colorectal cancer (CRC) remain elusive. In
Externí odkaz:
https://doaj.org/article/24ea662b880c4a82956f730b0fff077c
Autor:
Wang Xiao, Rong-Chang Cao, Wan-Jun Yang, Jie-Hui Tan, Ruo-Qi Liu, He-Ping Kan, Lei Zhou, Na Zhang, Zhi-Ye Chen, Xue-Mei Chen, Jia Xu, Guo-Wei Zhang, Peng Shen
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Background: Pancreatic cancer (PC) is prevalent among malignant tumors with poor prognosis and lacks efficient therapeutic strategies. Endoplasmic reticulum (ER) stress and apoptosis are associated with chronic inflammation and cancer progression. Ho
Externí odkaz:
https://doaj.org/article/acc4ac8a9f8e4f62bf0952a3340d4ebb
Autor:
Lukas Garrido Albertino, Ana Luísa Holanda Albuquerque, Julia Franco Ferreira, João Pedro Marmol Oliveira, Alexandre Secorun Borges, Thais Helena Constantino Patelli, José Paes Oliveira-Filho
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
APAF1 is an autosomal recessive inherited mutation, associated with Holstein haplotype 1 (HH1) and characterized by a substitution of cytosine for a thymine (c.1741C>T) in chromosome 5. The mutation causes fetal and embryonic loss, between 60 and 200
Externí odkaz:
https://doaj.org/article/b6b09e410bc44defa48a22bf3a39d5be
Autor:
Wenbo Yuan, Rui Zhou, Jingzi Wang, Jie Han, Xiao Yang, Hao Yu, Hongcheng Lu, Xiaolei Zhang, Pengchao Li, Jun Tao, Jifu Wei, Qiang Lu, Haiwei Yang, Min Gu
Publikováno v:
Molecular Oncology, Vol 13, Iss 7, Pp 1559-1576 (2019)
Circular RNAs (circRNAs) have recently emerged as essential regulators in carcinogenesis and cancer progression. Previous studies have shown that Cdr1as functions as a microRNA (miRNA) sponge in various cancer types. However, the role of Cdr1as in ci
Externí odkaz:
https://doaj.org/article/18be2d484fe7459cab47b787697210b4
Autor:
Bin Chen, Pengbo Wen, Guanshuo Hu, Yang Gao, Xiaojing Qi, Kaili Zhu, Shaopeng Chen, Lijun Wu, An Xu, Guoping Zhao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Radiotherapy is an essential curative treatment modality for colorectal cancer. Apoptosis is the major mechanism of IR-induced cell death and aberrant apoptotic signaling results in radioresistance, which is a hallmark of most, perhaps all, types of
Externí odkaz:
https://doaj.org/article/cc83d71cdea240ba8baa5ed4c3fb9900
Autor:
Ksenia Orekhova, Sandro Mazzariol, Beatrice Sussan, Massimo Bucci, Federico Bonsembiante, Ranieri Verin, Cinzia Centelleghe
Publikováno v:
Veterinary Sciences, Vol 8, Iss 10, p 203 (2021)
Seizures in puppies often present a diagnostic challenge in terms of identifying and treating the underlying cause. Dog breeds with mutations of the MDR1-gene are known to show adverse reactions to certain drugs, yet metabolic imbalance exacerbated b
Externí odkaz:
https://doaj.org/article/feb7e9adc89e4409bde2657630bd227e
Autor:
Maria Esperanza Rodriguez-Ruiz, Aitziber Buqué, Michal Hensler, Jonathan Chen, Norma Bloy, Giulia Petroni, Ai Sato, Takahiro Yamazaki, Jitka Fucikova, Lorenzo Galluzzi
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as a mechanism of resistance to cytotoxic therapeutics. Alongside, CASP3 regulates stress-responsive immunomodulatory pathways, includ
Externí odkaz:
https://doaj.org/article/d5d155fc51d74b22b14d6a824e4ff118