Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-κB, a link between inflammation and mineralization

Autor: Katalin Éva Sikura, Zsolt Combi, László Potor, Tamás Szerafin, Zoltán Hendrik, Gábor Méhes, Péter Gergely, Matthew Whiteman, Lívia Beke, Ibolya Fürtös, György Balla, József Balla

Publikováno v: Journal of Advanced Research, Vol 27, Iss , Pp 165-176 (2021)

Introduction: Hydrogen sulfide (H2S) was revealed to inhibit aortic valve calcification and inflammation was implicated in the pathogenesis of calcific aortic valve disease (CAVD). Objectives: We investigate whether H2S inhibits mineralization via ab

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Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-κB, a link between inflammation and mineralization.

Autor: Éva Sikura K; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary., Combi Z; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary., Potor L; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary., Szerafin T; Department of Cardiac Surgery, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary., Hendrik Z; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.; Department of Pathology, University of Debrecen, Faculty of Medicine, 4012 Debrecen, Hungary., Méhes G; Department of Pathology, University of Debrecen, Faculty of Medicine, 4012 Debrecen, Hungary., Gergely P; Department of Forensic Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Whiteman M; University of Exeter Medical School, St. Luke's Campus, Magdalen Road, Exeter EX1 2LU, UK., Beke L; Department of Pathology, University of Debrecen, Faculty of Medicine, 4012 Debrecen, Hungary., Fürtös I; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary., Balla G; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary.; Department of Pediatrics, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary., Balla J; Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4012 Debrecen, Hungary.; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary.

Publikováno v: Journal of advanced research [J Adv Res] 2020 Jul 21; Vol. 27, pp. 165-176. Date of Electronic Publication: 2020 Jul 21 (Print Publication: 2021).