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Akademický článek

Rapid Regulation of Human Mesenchymal Stem Cell Proliferation Using Inducible Caspase-9 Suicide Gene for Safe Cell-Based Therapy

Autor: Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 22, p 5759 (2019)

The regulation of transplanted cell proliferation and function is important to achieve safe cell-based therapies. We previously reported that the proliferation and function of transplanted cells, which expressed the herpes simplex virus thymidine kin

Externí odkaz: https://doaj.org/article/a65e2b257fc049f4a57db9c39ed89292

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Akademický článek

Death switch for gene therapy: application to erythropoietin transgene expression

Autor: D.S. Souza, D.M. Spencer, T.S.I. Salles, M.A. Salomão, E. Payen, Y. Beuzard, H.F. Carvalho, F.F. Costa, S.T.Olalla Saad

Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 43, Iss 7, Pp 634-644 (2010)

The effectiveness of the caspase-9-based artificial "death switch" as a safety measure for gene therapy based on the erythropoietin (Epo) hormone was tested in vitro and in vivo using the chemical inducer of dimerization, AP20187. Plasmids encoding t

Externí odkaz: https://doaj.org/article/f443a27be63545a8acc4abae5d78fb36

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Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2-/- mouse

Autor: Nicholas F. LaRusso, Nicholas E. Pirius, Steven P. O'Hara, Mohammed Al-Suraih, Julie E. Woodrum

Publikováno v: JHEP Reports, Vol 3, Iss 3, Pp 100250-(2021)
JHEP Reports

Summary Background & Aims Cholangiocyte senescence is important in the pathogenesis of primary sclerosing cholangitis (PSC). We found that CDKN2A (p16), a cyclin-dependent kinase inhibitor and mediator of senescence, was increased in cholangiocytes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f716cdeea2c8fc157b16ea60edf8391
http://www.sciencedirect.com/science/article/pii/S2589555921000264

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Rapid Regulation of Human Mesenchymal Stem Cell Proliferation Using Inducible Caspase-9 Suicide Gene for Safe Cell-Based Therapy

Autor: Makiya Nishikawa, Kosuke Kusamori, Mari Tsujimura

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 22
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5759 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22435f0efa696ec844eaa3909ec63b02
http://europepmc.org/articles/PMC6887989

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Akademický článek

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Death switch for gene therapy: application to erythropoietin transgene expression

Autor: Hernandes F. Carvalho, E Payen, F. F. Costa, T S I Salles, D M Spencer, S. T. Olalla Saad, M A Salomão, Y Beuzard, Dorotéia Rossi Silva Souza

Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 43, Iss 7, Pp 634-644 (2010)
Brazilian Journal of Medical and Biological Research, Volume: 43, Issue: 7, Pages: 634-644, Published: JUL 2010
Brazilian Journal of Medical and Biological Research v.43 n.7 2010
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC

The effectiveness of the caspase-9-based artificial “death switch” as a safety measure for gene therapy based on the erythro-poietin (Epo) hormone was tested in vitro and in vivo using the chemical inducer of dimerization, AP20187. Plasmids encod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb51e0fcac65b1b1d8661d6dd5f87f2
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700005

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