Zobrazeno 1 - 10
of 3 144
pro vyhledávání: '"AP site"'
Autor:
Anastasia D. Stolyarenko, Anna A. Novikova, Evgeniy S. Shilkin, Valentin A. Poltorachenko, Alena V. Makarova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 4107 (2024)
Eukaryotic REV1 serves as a scaffold protein for the coordination of DNA polymerases during DNA translesion synthesis. Besides this structural role, REV1 is a Y-family DNA polymerase with its own distributive deoxycytidyl transferase activity. Howeve
Externí odkaz:
https://doaj.org/article/db2c3bfc387a489d884330840bce02cc
Autor:
Peng Lu, Xiangjian Cao, Jinghui Zheng, Chenxv Zhu, Ruilan Zhang, Ying Sun, Ziyu Yang, Ziyu Tang, Jiayu Wang, Meiping Zhao
Publikováno v:
Biosensors and Bioelectronics: X, Vol 14, Iss , Pp 100329- (2023)
As a multifunctional DNA repair enzyme, human apurinic/apyrimidinic endonuclease 1 (APE1) plays a pivotal role in many cellular processes. In recent years, it has been recognized as a potential prognostic biomarker and a therapeutic target for many c
Externí odkaz:
https://doaj.org/article/bab3d95ac127475ca28885b6aef81df5
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 54, Pp 637-646 (2022)
Apurinic/apyrimidic (AP) sites are severe DNA damages and strongly block DNA extension by major DNA polymerases. Y-family DNA polymerases possess a strong ability to bypass AP sites and continue the DNA synthesis reaction, which is called translesion
Externí odkaz:
https://doaj.org/article/0d8a87c909564578aea3db05c1482bd4
Akademický článek
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Akademický článek
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Autor:
Anna R. Poetsch
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 207-219 (2020)
Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of disrupting genome function, inducing genome instability and mutation. Such risks are due to primary oxidative DNA damage and also mediated by the repair proces
Externí odkaz:
https://doaj.org/article/b68a7743876e4df3ba1be20a4c155f13
Autor:
Dong Min Kang, Jong-Il Shin, Ji Beom Kim, Kyungho Lee, Ji Hyung Chung, Hye-Won Yang, Kil-Nam Kim, Ye Sun Han
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Reactive oxygen species (ROS) produce different lesions in DNA by ROS-induced DNA damage. Detection and quantification of 8-oxo-7,8-dihydroguanine (8-oxoG) within cells are important for study. Human ribosomal protein S3 (hRpS3) h
Externí odkaz:
https://doaj.org/article/ca91d2cbbc584c74abd1d5ac489e2cae
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13353 (2022)
Azide–alkyne cycloaddition (“click chemistry”) has found wide use in the analysis of molecular interactions in living cells. 5-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol (EAP) is a recently developed apurinic/apyrimidinic (AP) site analog fu
Externí odkaz:
https://doaj.org/article/252bc00ba401445b97baf5ed8a74d3ee
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2729 (2022)
The spontaneous depurination of genomic DNA occurs frequently and generates apurinic/pyrimidinic (AP) site damage that is mutagenic or lethal to cells. Error-prone DNA polymerases are specifically responsible for the translesion synthesis (TLS) of sp
Externí odkaz:
https://doaj.org/article/0908b34f143249bc92a1fbd1e497133f