Zobrazeno 1 - 9
of 9
pro vyhledávání: '"AP, alternative pathway"'
Publikováno v:
The Journal of Biological Chemistry
Inhibition of the alternative pathway (AP) of complement by saliva from Anopheles mosquitoes facilitates feeding by blocking production of the anaphylatoxins C3a and C5a, which activate mast cells leading to plasma extravasation, pain, and itching. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56b0ff8857a97987bd856e00dd37e49
https://pubmed.ncbi.nlm.nih.gov/33199367
https://pubmed.ncbi.nlm.nih.gov/33199367
Publikováno v:
Ophthalmology, 126, 1422-1423
Ophthalmology: Journal of The American Academy of Ophthalmology, 126(10), 1422-1423
Ophthalmology
Ophthalmology, 126(10), 1422-1423. Elsevier Inc.
Ophthalmology, 126, 10, pp. 1422-1423
Ophthalmology: Journal of The American Academy of Ophthalmology, 126(10), 1422-1423
Ophthalmology
Ophthalmology, 126(10), 1422-1423. Elsevier Inc.
Ophthalmology, 126, 10, pp. 1422-1423
Purpose To characterize the molecular mechanism underpinning early-onset macular drusen (EOMD), a phenotypically severe subtype of age-related macular degeneration (AMD), in a subgroup of patients. Design Multicenter case series, in vitro experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ae99f556fdb3f41c094e17d51c0655
https://doi.org/10.1016/j.ophtha.2019.04.033
https://doi.org/10.1016/j.ophtha.2019.04.033
Autor:
Rolf T. Urbanus, Kim Dijkxhoorn, Karen Silence, Peter Boross, Elisabeth de Zeeuw, Louis Boon, Jan Meeldijk, Christophe Blanchetot, Jeanette H. W. Leusen, Sofie Gabriels, Henny G. Otten, Liesbeth Van de Ven, Kevin Budding, Hans de Haard, Jean-Michel Percier, Rob Holgate, Peter J. Simons, Johanna Wildemann, C. Erik Hack, Inge Van de Walle, Linda J. Cox, Cafer Yildiz
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background Activation of the classical and lectin pathway of complement may contribute to tissue damage and organ dysfunction of antibody-mediated diseases and ischemia-reperfusion conditions. Complement factors are being considered as targets for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fe17fec6eb2a3b3724be8ca3d9a198
https://doi.org/10.1016/j.jaci.2020.08.028
https://doi.org/10.1016/j.jaci.2020.08.028
Autor:
Mitchell J. de Souza, Matthew P. Hardy, Martin J. Pearse, Kim G. Lieu, Saw Yen Ow, Martin O. Spycher, Anup G. Nair, Michael J. Wilson, Jason Simmonds, Yun Dai, Sandra Wymann, Adrian Zuercher, Anna Schnell, Con Panousis, Rebecca E. Butcher, Glenn A. Powers, Marcel Mischnik, Tony Rowe, Genevieve Martin-Roussety, Adriana Baz Morelli, Helen Cao, David Leong, Shirley Taylor
Publikováno v:
The Journal of Biological Chemistry
Human complement receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all three complement pathways as a membrane-bound receptor of C3b/C4b, C3/C5 convertase decay accelerator, and cofactor for factor I-mediated cleavage of C3b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605c43f8a6fc70ffcd57fb8866f643b1
https://doi.org/10.1074/jbc.ra120.016127
https://doi.org/10.1074/jbc.ra120.016127
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 4, Pp 316-322 (2015)
Acta Pharmaceutica Sinica B, Vol 5, Iss 4, Pp 316-322 (2015)
Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a957bcdfda77609b1333850e0b66bf
http://europepmc.org/articles/PMC4629277
http://europepmc.org/articles/PMC4629277
Autor:
Jayne L. Chamberlain-Banoub, Bryan Paul Morgan, Natalie J. Hepburn, Anwen Sian Williams, Claire L. Harris
Publikováno v:
Molecular Immunology
Despite its vital role in innate immunity, complement is involved in a number of inflammatory pathologies and has therefore become a therapeutic target. Most agents generated for anti-complement therapy have short half-lives in plasma, or have been o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63c574336baab19a4a86867dcbe5c82
https://doi.org/10.1016/j.molimm.2007.06.144
https://doi.org/10.1016/j.molimm.2007.06.144
Autor:
Martínez-Barricarte, Rubén, Heurich, Meike, López-Perrote, Andrés, Tortajada, Agustin, Pinto, Sheila, López-Trascasa, Margarita, Sánchez-Corral, Pilar, Morgan, B. Paul, Llorca, Oscar, Harris, Claire L., Rodríguez de Córdoba, Santiago
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Molecular Immunology
Consejería de Sanidad de la Comunidad de Madrid
Molecular Immunology
Highlights • Mutations in C3 have been associated with aHUS and other glomerulopathies. • aHUS-associated C3 mutants R592W, R161W, and I1157T impair regulation by MCP, but not by FH. • EM analysis provides the structural basis for the functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::55295c489a9386cf1427c8a49fe646f9
https://saludmadrid.ibai.com/handle/20.500.12530/22195
https://saludmadrid.ibai.com/handle/20.500.12530/22195
Publikováno v:
Bioscience Reports
aHUS (atypical haemolytic uraemic syndrome), AMD (age-related macular degeneration) and other diseases are associated with defective AP (alternative pathway) regulation. CFH (complement factor H), CFI (complement factor I), MCP (membrane cofactor pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b85f79bcdb8751a8075d9c906916e95d
https://pubmed.ncbi.nlm.nih.gov/25188723
https://pubmed.ncbi.nlm.nih.gov/25188723
Autor:
Wu M; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Li H; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Zhang Y; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China., Chen D; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2015 Jul; Vol. 5 (4), pp. 316-22. Date of Electronic Publication: 2015 Apr 07.