In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment

Autor: Mariano Vázquez, Alfonso Santiago, Alfonso Bueno-Orovio, Blanca Rodriguez, Francesca Margara, Zhinuo J. Wang, Francesc Levrero-Florencio

Publikováno v: Progress in Biophysics and Molecular Biology
OpenAIRE
PubMed Central
UnpayWall
ORCID
Microsoft Academic Graph
Sygma

Human-based computational modelling and simulation are powerful tools to accelerate the mechanistic understanding of cardiac patho-physiology, and to develop and evaluate therapeutic interventions. The aim of this study is to calibrate and evaluate h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f5102b0bbc233b1af7bc652ae25f38

A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs

Autor: Stephen D. Meriney, Manuel Covarrubias, Gloria Ortiz, Evan W. Miller, Scott P. Ginebaugh, Kristine S. Ojala, Man Wu

Publikováno v: The Journal of Biological Chemistry

3,4-Diaminopyridine (3,4-DAP) increases transmitter release from neuromuscular junctions (NMJs), and low doses of 3,4-DAP (estimated to reach ∼1 μM in serum) are the Food and Drug Administration (FDA)-approved treatment for neuromuscular weakness

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbc3cf8e9a87415c7993f465b092f47
https://pubmed.ncbi.nlm.nih.gov/33465376

Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

Autor: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez

Publikováno v: Toxicology and Applied Pharmacology

Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in sil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291b9744f97d46ac0f6fd500ad2e1c0f
http://europepmc.org/articles/PMC7322544

Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure

Autor: Kevin J. Munro, Christopher J. Plack, Garreth Prendergast, Rebecca E. Millman, Hannah Guest

Publikováno v: Guest, H, Munro, K, Prendergast, G, Millman, R & Plack, C 2018, ' Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure ', Hearing Research, vol. 364, pp. 142-151 . https://doi.org/10.1016/j.heares.2018.03.008
Hearing Research

In rodents, noise exposure can destroy synapses between inner hair cells and auditory nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced cochlear synaptopathy usually leaves cochlear thresholds unaltered, but is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354a66e3557e1227b9b615e1d33dfb30
https://doi.org/10.1016/j.heares.2018.03.008

Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy

Autor: Long-Sheng Song, Francesco S. Pavone, Luca Mazzoni, Chiara Tesi, Josè Manuel Pioner, Claudia Crocini, Leonardo Sacconi, Jil C. Tardiff, Elisabetta Cerbai, Beatrice Scellini, Ping Yan, Leslie M. Loew, Erica Lazzeri, Cecilia Ferrantini, Francesco Vanzi, Raffaele Coppini, Ang Guo, Corrado Poggesi, Marina Scardigli

Publikováno v: Journal of Molecular and Cellular Cardiology 91 (2016): 42–51. doi:10.1016/j.yjmcc.2015.12.013
info:cnr-pdr/source/autori:Crocini, C.; Ferrantini, C.; Scardigli, M.; Coppini, R.; Mazzoni, L.; Lazzeri, E.; Pioner, J. M.; Scellini, B.; Guo, A.; Song, L. S.; Yan, P.; Loew, L. M.; Tardiff, J.; Tesi, C.; Vanzi, F.; Cerbai, E.; Pavone, F. S.; Sacconi, L.; Poggesi, C./titolo:Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy/doi:10.1016%2Fj.yjmcc.2015.12.013/rivista:Journal of Molecular and Cellular Cardiology/anno:2016/pagina_da:42/pagina_a:51/intervallo_pagine:42–51/volume:91
Journal of Molecular and Cellular Cardiology

Abnormalities of cardiomyocyte Ca2 + homeostasis and excitation–contraction (E–C) coupling are early events in the pathogenesis of hypertrophic cardiomyopathy (HCM) and concomitant determinants of the diastolic dysfunction and arrhythmias typical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0622cba30ea6e03df3a8690c8d7c751e
https://doi.org/10.1016/j.yjmcc.2015.12.013