The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia

Autor: Anderson Brito da Silva, Jane Pennifold, Ben Henley, Koustav Chatterjee, David Bateman, Roger W. Whittaker, Abhijit Joshi, Hrishikesh Kumar, Claire Nicholson, Mark R. Baker, Stuart D. Greenhill, Richard Walsh, Stefano Seri, Roland S. G. Jones, Gavin L. Woodhall, Mark O. Cunningham

Publikováno v: Epilepsia Open, Vol 7, Iss 3, Pp 488-495 (2022)

Abstract Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresis

Externí odkaz: https://doaj.org/article/4f75c11420504a2b92f84ffdac58cc0c

[Untitled]

Autor: Anderson Barbosa Silva, Marcela Fonseca Souza, Alisson Harley Brito da Silva, Obertal da Silva Almeida, Anderson Brito da Silva, Cláudio Lúcio Fernandes Amaral

Publikováno v: Biotemas, Vol 21, Iss 2, Pp 33-40 (2008)

O gênero Ocimum (Lamiaceae) compreende plantas ricas em óleos esse- nciais destinados às indústrias para a produção de fármacos, perfumes, cosméticos e temperos. Foi objetivo deste trabalho estudar a biologia floral e os mecanismos reprodutiv

Externí odkaz: https://doaj.org/article/ea7e86e5214e4127bfc8783fc079efa5

The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia

Autor: Claire Nicholson, Hrishikesh Kumar, Gavin L. Woodhall, Richard A. Walsh, Roger W. Whittaker, Stuart D. Greenhill, Abhijit Joshi, Mark O. Cunningham, Anderson Brito da Silva, Jane Pennifold, Ben Henley, Koustav Chatterjee, David Bateman, Mark R. Baker, Stefano Seri, Roland S.G. Jones

Publikováno v: Epilepsia open. 7(3)

Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresistant natu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8481ea5175d14149b08bb80cf38cd1
https://pubmed.ncbi.nlm.nih.gov/34653311

Human brain slices for epilepsy research:pitfalls, solutions and future challenges

Autor: Roger G. Whittaker, Gavin L. Woodhall, Mark O. Cunningham, Anderson Brito da Silva, Roland S.G. Jones

Publikováno v: Jones, R S G, Brito da Silva, A, Whittaker, R G, Woodhall, G L & Cunningham, M O 2016, ' Human brain slices for epilepsy research : pitfalls, solutions and future challenges ', Journal of Neuroscience Methods, vol. 260, pp. 221-232 . https://doi.org/10.1016/j.jneumeth.2015.09.021

Increasingly, neuroscientists are taking the opportunity to use live human tissue obtained from elective neurosurgical procedures for electrophysiological studies in vitro. Access to this valuable resource permits unique studies into the network dyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d0de414087f9756b2fa08a9326083e
https://publications.aston.ac.uk/id/eprint/27757/1/Human_brain_slices_for_epilepsy_research.pdf

Biologia floral e mecanismos reprodutivos de Ocimum canum Sims (Lamiaceae)

Autor: Obertal da Silva Almeida, Marcela Fonseca Souza, Cláudio Lúcio Fernandes Amaral, Anderson Brito da Silva, Alisson Harley Brito da Silva, Anderson Barbosa Silva

Publikováno v: Biotemas; v. 21 n. 2 (2008); 33-40
Biotemas
Universidade Federal de Santa Catarina (UFSC)
instacron:UFSC

Floral biology and reproductive mechanisms of the Ocimum canum Sims (Lamiaceae). The Ocimum genus (Lamiaceae) presents essential oils used in the pharmaceutical, perfume, cosmetics and culinary industries. The aim of this paper was to study the fl or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fe6018336620d6dc44ed16d62ead37
https://periodicos.ufsc.br/index.php/biotemas/article/view/2175-7925.2008v21n2p33