Zobrazeno 1 - 10
of 48
pro vyhledávání: '"ANZgene"'
Autor:
Michele D Binder, Andrew D Fox, Daniel Merlo, Laura J Johnson, Lauren Giuffrida, Sarah E Calvert, Rainer Akkermann, Gerry Z M Ma, ANZgene, Ashwyn A Perera, Melissa M Gresle, Louise Laverick, Grace Foo, Marzena J Fabis-Pedrini, Timothy Spelman, Margaret A Jordan, Alan G Baxter, Simon Foote, Helmut Butzkueven, Trevor J Kilpatrick, Judith Field
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005853 (2016)
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The risk of developing MS is strongly influenced by genetic predisposition, and over 100 loci have been established as associated with susceptibili
Externí odkaz:
https://doaj.org/article/0cd521e396da40b7bb93def308a10e36
Autor:
Nikolaos A Patsopoulos, Lisa F Barcellos, Rogier Q Hintzen, Catherine Schaefer, Cornelia M van Duijn, Janelle A Noble, Towfique Raj, IMSGC, ANZgene, Pierre-Antoine Gourraud, Barbara E Stranger, Jorge Oksenberg, Tomas Olsson, Bruce V Taylor, Stephen Sawcer, David A Hafler, Mary Carrington, Philip L De Jager, Paul I W de Bakker
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003926 (2013)
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation. Using SNP d
Externí odkaz:
https://doaj.org/article/6e4e6d6e785f43918ef55c820b6ebf1f
Identity-by-descent mapping to detect rare variants conferring susceptibility to multiple sclerosis.
Autor:
Rui Lin, Jac Charlesworth, Jim Stankovich, Victoria M Perreau, Matthew A Brown, ANZgene Consortium, Bruce V Taylor
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e56379 (2013)
Genome-wide association studies (GWAS) have identified around 60 common variants associated with multiple sclerosis (MS), but these loci only explain a fraction of the heritability of MS. Some missing heritability may be caused by rare variants that
Externí odkaz:
https://doaj.org/article/d25e2232bc334290992608243f48933a
Autor:
Carlos Riveros, Drew Mellor, Kaushal S Gandhi, Fiona C McKay, Mathew B Cox, Regina Berretta, S Yahya Vaezpour, Mario Inostroza-Ponta, Simon A Broadley, Robert N Heard, Stephen Vucic, Graeme J Stewart, David W Williams, Rodney J Scott, Jeanette Lechner-Scott, David R Booth, Pablo Moscato, ANZgene Multiple Sclerosis Genetics Consortium
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14176 (2010)
BackgroundSeveral lines of evidence suggest that transcription factors are involved in the pathogenesis of Multiple Sclerosis (MS) but complete mapping of the whole network has been elusive. One of the reasons is that there are several clinical subty
Externí odkaz:
https://doaj.org/article/57cf07fc99e548b88dcd763073a08da1
Autor:
Mathew B Cox, Murray J Cairns, Kaushal S Gandhi, Adam P Carroll, Sophia Moscovis, Graeme J Stewart, Simon Broadley, Rodney J Scott, David R Booth, Jeannette Lechner-Scott, ANZgene Multiple Sclerosis Genetics Consortium
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12132 (2010)
It is well established that Multiple Sclerosis (MS) is an immune mediated disease. Little is known about what drives the differential control of the immune system in MS patients compared to unaffected individuals. MicroRNAs (miRNAs) are small non-cod
Externí odkaz:
https://doaj.org/article/08421e7245d1407d9ac2d8dacc401bf5
Akademický článek
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Autor:
Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalbán X, Polman CH, Freedman MS, Hartung HP, Arnason BGW, COMI , GIANCARLO, Cook S, FILIPPI , MASSIMO, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk J, Hillert J, Bahlo M, Booth DR, BroadleyS, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi F, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak Vance M, Sawcer SJ, De Jager PL, Hafler DA, de Bakker PIW, the BSP MS Genetics working group, the steering committees of studies evaluating IFNb 1b, a. CCR1 antagonist, ANZgene Consortium, GeneMSA, International Multiple Sclerosis Genetics Consortium
Publikováno v:
Annals of Neurology, 70(6), 897-912. John Wiley and Sons Inc.
Patsopoulos, N A, Bakker, P I W & Polman, C H 2011, ' Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci ', Annals of Neurology, vol. 70, no. 6, pp. 897-912 . https://doi.org/10.1002/ana.22609
Patsopoulos, N A, Bakker, P I W & Polman, C H 2011, ' Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci ', Annals of Neurology, vol. 70, no. 6, pp. 897-912 . https://doi.org/10.1002/ana.22609
OBJECTIVE: To perform a 1-stage meta-analysis of genome-wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and to explore functional consequences of new susceptibility loci. METHODS: We synthesized 7 MS GWAS. Each data set was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef8585134ddd788a2ca78fc05301762
https://doi.org/10.1002/ana.22609
https://doi.org/10.1002/ana.22609
Autor:
Simon J. Foote, Michele D. Binder, Lauren Giuffrida, Alan G. Baxter, Margaret A. Jordan, Trevor J. Kilpatrick, Daniel Merlo, Tim Spelman, Melissa Gresle, Louise Laverick, Andrew Fox, ANZgene, Marzena J. Fabis-Pedrini, Rainer Akkermann, Sarah E. Calvert, Gerry Z. M. Ma, Ashwyn A. Perera, Laura J. Johnson, Helmut Butzkueven, Grace Foo, Judith Field
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 3, p e1005853 (2016)
PLoS Genetics, Vol 12, Iss 3, p e1005853 (2016)
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The risk of developing MS is strongly influenced by genetic predisposition, and over 100 loci have been established as associated with susceptibili
Akademický článek
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Akademický článek
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