Zobrazeno 1 - 10
of 915
pro vyhledávání: '"ANTIPROLIFERATIVE ACTIVITIES"'
Autor:
Hongting Li, Mei-Qi Jia, Zhao-Long Qin, Changliang Lu, Weili Chu, Ze Zhang, Jinbo Niu, Jian Song, Sai-Yang Zhang, Lijun Fu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
In this work, thirty 2,4-diarylaminopyrimidine-based hydrazones were designed, synthesised, and their anti-thyroid cancer activity were explored. The majority of compounds exhibit moderate to excellent cytotoxic activity against FAK overexpressing TP
Externí odkaz:
https://doaj.org/article/3e5f919cf9494c6aa0bf6eb6243ae030
Autor:
Tsvetelina Andonova, Yordan Muhovski, Elena Apostolova, Samir Naimov, Silviya Mladenova, Iliya Slavov, Ivayla Dincheva, Vasil Georgiev, Atanas Pavlov, Ivanka Dimitrova-Dyulgerova
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1200 (2024)
Nowadays, interest in natural antioxidants (especially phenolics) for the prevention of oxidative stress-related diseases is increasing due to their fewer side effects and more potent activity than some of their synthetic analogues. New chemical and
Externí odkaz:
https://doaj.org/article/afbf7c7716324751990b299c6bdc4359
Autor:
Igor Henrique Cerqueira, Maria Julia Mieli, Anna Karla dos Santos Pereira, Pedro Paulo Corbi, Flavia Aparecida Resende
Publikováno v:
Química Nova, Vol 47, Iss 6 (2024)
Silver(I) complexes of amantadine (atdH), memantine (mtnH) and rimantadine (rtdH), named Ag-atd, Ag-mtn and Ag-rtd, respectively, were recently synthesized and described in the literature as promising antibacterial agents. In the present study, the c
Externí odkaz:
https://doaj.org/article/65947696083b4466a10f812ee3c2b0d5
Autor:
Xiao-Yi Shi, Huang Jiao, Jia-Kai Zhang, Xin-Yi Tian, Dan-Feng Guo, Jie Gao, Mei-Qi Jia, Jian Song, Sai-Yang Zhang, Xiang-Jing Fu, Hong-Wei Tang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
In this work, a series of novel arylamide derivatives containing piperazine moiety were designed and synthesised as tubulin polymerisation inhibitors. Among 25 target compounds, compound 16f (MY-1121) exhibited low nanomolar IC50 values ranging from
Externí odkaz:
https://doaj.org/article/a0144550c46b4d9d907af2036c581cb4
Autor:
Martina Falcione, Alessandra Renella, Vadym Samukha, Mayra Colardo, Melissa Simiele, Gabriella Stefania Scippa, Marco Segatto, Dalila Trupiano
Publikováno v:
Diversity, Vol 16, Iss 4, p 240 (2024)
Common bean landraces, besides contributing to the preservation of the social and cultural identity of the local communities of the production area, typically display adaptability to adverse agro-climatic conditions. This adapted germplasm is a repos
Externí odkaz:
https://doaj.org/article/934ca18c4e204d57ab897195402e19cd
Akademický článek
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Akademický článek
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Autor:
Jean Guillon, Marc Le Borgne, Vittoria Milano, Aurore Guédin-Beaurepaire, Stéphane Moreau, Noël Pinaud, Luisa Ronga, Solène Savrimoutou, Sandra Albenque-Rubio, Mathieu Marchivie, Haouraa Kalout, Charley Walker, Louise Chevallier, Corinne Buré, Eric Largy, Valérie Gabelica, Jean-Louis Mergny, Virginie Baylot, Jacky Ferrer, Yamina Idrissi, Edith Chevret, David Cappellen, Vanessa Desplat, Zsuzsanna Schelz, István Zupkó
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 30 (2023)
The syntheses of novel 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazolines 12 and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinolines 13 are reported here in six steps starting from various halogeno-quinazoline-2,4-(1H,3H)-diones or subst
Externí odkaz:
https://doaj.org/article/a1792b25a47e4834a049e8058f8ad1b4
Akademický článek
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Autor:
Amanda A. Silva, Silmara C. L. Frajácomo, Állefe B. Cruz, Kaio Eduardo Buglio, Daniele Daiane Affonso, Marcelo Cecconi Portes, Ana Lúcia T. G. Ruiz, João Ernesto de Carvalho, Wilton R. Lustri, Douglas H. Pereira, Ana M. da Costa Ferreira, Pedro P. Corbi
Publikováno v:
Inorganics, Vol 11, Iss 8, p 331 (2023)
The growth of antibiotic resistance is a matter of worldwide concern. In parallel, cancer remains one of the main causes of death. In the search for new and improved antiproliferative agents, one of the strategies is the combination of bioactive liga
Externí odkaz:
https://doaj.org/article/1adce2202e1344e8bedea21371e73b5c