Zobrazeno 1 - 10
of 291
pro vyhledávání: '"ANTHONY D WHETTON"'
Autor:
Stella Pearson, Rognvald Blance, Fei Yan, Ya-Ching Hsieh, Bethany Geary, Fabio M R Amaral, Tim C P Somervaille, Kristina Kirschner, Anthony D Whetton, Andrew Pierce
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286412 (2023)
Myelofibrosis is a myeloproliferative neoplasm (MPN) which typically results in reduced length and quality of life due to systemic symptoms and blood count changes arising from fibrotic changes in the bone marrow. While the JAK2 inhibitor ruxolitinib
Externí odkaz:
https://doaj.org/article/68dcd073260444a9951df4bb64585f57
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0266298 (2022)
Despite the big increase in precision medicine targeted therapies developing curative treatments for many cancers is still a major challenge due mainly to the development of drug resistance in cancer stem cells. The cancer stem cells are constantly e
Externí odkaz:
https://doaj.org/article/29d5104a52444955853afe0e14b6effc
Autor:
Angelica Arioli, Arianna Dagliati, Bethany Geary, Niels Peek, Philip A Kalra, Anthony D Whetton, Nophar Geifman
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249771 (2021)
BackgroundMissing values are a key issue in the statistical analysis of proteomic data. Defining the strategy to address missing values is a complex task in each study, potentially affecting the quality of statistical analyses.ResultsWe have develope
Externí odkaz:
https://doaj.org/article/51dbd7b310d74147b495df43c5a88159
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Specific food preferences can determine an individual’s dietary patterns and therefore, may be associated with certain health risks and benefits. Methods Using food preference questionnaire (FPQ) data from a subset comprising ov
Externí odkaz:
https://doaj.org/article/e25510f79d764c8f968b285425442bfa
Publikováno v:
Frontiers in Parasitology, Vol 3 (2024)
Cryptosporidium species are parasitic organisms of vertebrates with a worldwide distribution. They have an important impact globally upon human and animal health, and livestock productivity. The life cycle of these species is complex and difficult to
Externí odkaz:
https://doaj.org/article/1c126c7d27d8418aa8aa823d09511338
Autor:
Michael Schaller-Schönitz, David Barzan, Andrew J K Williamson, John R Griffiths, Iris Dallmann, Karin Battmer, Arnold Ganser, Anthony D Whetton, Michaela Scherr, Matthias Eder
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97243 (2014)
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors linking extracellular signals to target gene transcription. Hematopoietic cells express two highly conserved STAT5-isoforms (STAT5A/STAT5B), and S
Externí odkaz:
https://doaj.org/article/bb2aa3c0442c49178458366adc06032b
Autor:
Daniel J White, Richard D Unwin, Eric Bindels, Andrew Pierce, Hsiang-Ying Teng, Joanne Muter, Brigit Greystoke, Tim D Somerville, John Griffiths, Simon Lovell, Tim C P Somervaille, Ruud Delwel, Anthony D Whetton, Stefan Meyer
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66510 (2013)
The EVI1 (ecotropic viral integration site 1) gene at 3q26 codes for a transcriptional regulator with an essential role in haematopoiesis. Overexpression of EVI1 in acute myeloid leukaemia (AML) is frequently associated with 3q26 rearrangements and c
Externí odkaz:
https://doaj.org/article/141dd3f8431543018895f1f52fcb5fcb
Autor:
Andrew Pierce, Andrew Williamson, Ewa Jaworska, John R Griffiths, Sam Taylor, Michael Walker, Mark Aspinall-O'Dea, Elaine Spooncer, Richard D Unwin, Toryn Poolman, David Ray, Anthony D Whetton
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38928 (2012)
Mutated tyrosine kinases are associated with a number of different haematological malignancies including myeloproliferative disorders, lymphoma and acute myeloid leukaemia. The potential commonalities in the action of six of these leukemogenic protei
Externí odkaz:
https://doaj.org/article/196965d7fc1a435eaf81238cb16e8818
Autor:
Nicolas Bonadies, Samuel D Foster, Wai-In Chan, Brynn T Kvinlaug, Dominik Spensberger, Mark A Dawson, Elaine Spooncer, Anthony D Whetton, Andrew J Bannister, Brian J Huntly, Berthold Göttgens
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16330 (2011)
Acute leukaemias are commonly caused by mutations that corrupt the transcriptional circuitry of haematopoietic stem/progenitor cells. However, the mechanisms underlying large-scale transcriptional reprogramming remain largely unknown. Here we investi
Externí odkaz:
https://doaj.org/article/f71694be093f40c29177c6cacd436692
Autor:
Kelechi Njoku, Andrew Pierce, Davide Chiasserini, Bethany Geary, Amy E. Campbell, Janet Kelsall, Rachel Reed, Nophar Geifman, Anthony D. Whetton, Emma J. Crosbie
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105064- (2024)
Summary: Background: The anatomical continuity between the uterine cavity and the lower genital tract allows for the exploitation of uterine-derived biomaterial in cervico-vaginal fluid for endometrial cancer detection based on non-invasive sampling
Externí odkaz:
https://doaj.org/article/aa9847fd599d4a019d13e4ed6f2270e2