Zobrazeno 1 - 10
of 65
pro vyhledávání: '"ANNA MAROZZI"'
Autor:
Alessia Brix, Laura Belleri, Alex Pezzotta, Emanuela Pettinato, Mara Mazzola, Matteo Zoccolillo, Anna Marozzi, Rui Monteiro, Filippo Del Bene, Alessandra Mortellaro, Anna Pistocchi
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Deficiency of adenosine deaminase 2 (DADA2) is an inborn error of immunity caused by loss-of-function mutations in the adenosine deaminase 2 (ADA2) gene. Clinical manifestations of DADA2 include vasculopathy and immuno-hematological abnormal
Externí odkaz:
https://doaj.org/article/b91819917852418395db5a72ed44b50e
Autor:
Alex Pezzotta, Ilaria Gentile, Donatella Genovese, Maria Grazia Totaro, Cristina Battaglia, Anskar Yu-Hung Leung, Monica Fumagalli, Matteo Parma, Gianni Cazzaniga, Grazia Fazio, Myriam Alcalay, Anna Marozzi, Anna Pistocchi
Publikováno v:
Pharmacological Research, Vol 183, Iss , Pp 106378- (2022)
Aberrant activation of the Hh pathway promotes cell proliferation and multi-drug resistance (MDR) in several cancers, including Acute Myeloid Leukemia (AML). Notably, only one Hh inhibitor, glasdegib, has been approved for AML treatment, and most pat
Externí odkaz:
https://doaj.org/article/8bf0091488734988905b5edf67d83749
Autor:
Alex Pezzotta, Loredana Brioschi, Sabrina Carbone, Beatrice Mazzoleni, Vittorio Bontempi, Federica Monastra, Laura Mauri, Anna Marozzi, Marina Mione, Anna Pistocchi, Paola Viani
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5771 (2023)
Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults. The invasiveness and the rapid progression that characterize GBM negatively impact patients’ survival. Temozolomide (TMZ) is currently considered the first-choice
Externí odkaz:
https://doaj.org/article/446b70b9182844c491e5cedfb062ce6f
Autor:
Raffaella Rossetti, Silvia Moleri, Fabiana Guizzardi, Davide Gentilini, Laura Libera, Anna Marozzi, Costanzo Moretti, Francesco Brancati, Marco Bonomi, Luca Persani
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Primary ovarian insufficiency (POI) is one of the major causes of female infertility associated with the premature loss of ovarian function in about 3.7% of women before the age of 40. This disorder is highly heterogeneous and can manifest with a wid
Externí odkaz:
https://doaj.org/article/00700cf521134521bf5d875a717a7102
Autor:
Marco Spreafico, Alicja M. Gruszka, Debora Valli, Mara Mazzola, Gianluca Deflorian, Arianna Quintè, Maria Grazia Totaro, Cristina Battaglia, Myriam Alcalay, Anna Marozzi, Anna Pistocchi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Histone deacetylase 8 (HDAC8), a class I HDAC that modifies non-histone proteins such as p53, is highly expressed in different hematological neoplasms including a subtype of acute myeloid leukemia (AML) bearing inversion of chromosome 16 [inv(16)]. T
Externí odkaz:
https://doaj.org/article/9cdbd03a639740c7b6951f3d103b0f9c
Autor:
Vanilla Martina Vecchi, Marco Spreafico, Alessia Brix, Anna Santoni, Simone Sala, Anna Pistocchi, Anna Marozzi, Chiara Di Resta
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9720 (2021)
Different forms of sudden cardiac death have been described, including a recently identified form of genetic arrhythmogenic disorder, named “Triadin KnockOut Syndrome” (TKOS). TKOS is associated with recessive mutations in the TRDN gene, encoding
Externí odkaz:
https://doaj.org/article/8bdfd0e7a5de404aa24970b46fe9c341
Autor:
Mara Mazzola, Gianluca Deflorian, Alex Pezzotta, Laura Ferrari, Grazia Fazio, Erica Bresciani, Claudia Saitta, Luca Ferrari, Monica Fumagalli, Matteo Parma, Federica Marasca, Beatrice Bodega, Paola Riva, Franco Cotelli, Andrea Biondi, Anna Marozzi, Gianni Cazzaniga, Anna Pistocchi
Publikováno v:
Haematologica, Vol 104, Iss 7 (2019)
The nucleophosmin 1 gene (NPM1) is the most frequently mutated gene in acute myeloid leukemia. Notably, NPM1 mutations are always accompanied by additional mutations such as those in cohesin genes RAD21, SMC1A, SMC3, and STAG2 but not in the cohesin
Externí odkaz:
https://doaj.org/article/2a860a51750740278fb6788ba7cc49e3
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
The genes of the cohesin complex exert different functions, ranging from the adhesion of sister chromatids during the cell cycle, DNA repair, gene expression and chromatin architecture remodeling. In recent years, the improvement of DNA sequencing te
Externí odkaz:
https://doaj.org/article/6ff740f75dc44da6ba33d2a7776e66de
Autor:
Marco Spreafico, Eleonora Mangano, Mara Mazzola, Clarissa Consolandi, Roberta Bordoni, Cristina Battaglia, Silvio Bicciato, Anna Marozzi, Anna Pistocchi
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9719 (2020)
Transcriptional changes normally occur during development but also underlie differences between healthy and pathological conditions. Transcription factors or chromatin modifiers are involved in orchestrating gene activity, such as the cohesin genes a
Externí odkaz:
https://doaj.org/article/b4799455206244d794cb552f88b8b163
Autor:
Viani, Alex Pezzotta, Loredana Brioschi, Sabrina Carbone, Beatrice Mazzoleni, Vittorio Bontempi, Federica Monastra, Laura Mauri, Anna Marozzi, Marina Mione, Anna Pistocchi, Paola
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5771
Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults. The invasiveness and the rapid progression that characterize GBM negatively impact patients’ survival. Temozolomide (TMZ) is currently considered the first-choice