The G Protein Estrogen Receptor (GPER) is involved in the resistance to the CDK4/6 inhibitor palbociclib in breast cancer

Autor: Marianna Talia, Francesca Cirillo, Domenica Scordamaglia, Marika Di Dio, Azzurra Zicarelli, Salvatore De Rosis, Anna Maria Miglietta, Carlo Capalbo, Ernestina Marianna De Francesco, Antonino Belfiore, Fedora Grande, Bruno Rizzuti, Maria Antonietta Occhiuzzi, Giancarlo Fortino, Antonella Guzzo, Gianluigi Greco, Marcello Maggiolini, Rosamaria Lappano

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)

Abstract Background The cyclin D1-cyclin dependent kinases (CDK)4/6 inhibitor palbociclib in combination with endocrine therapy shows remarkable efficacy in the management of estrogen receptor (ER)-positive and HER2-negative advanced breast cancer (B

Externí odkaz: https://doaj.org/article/953c860ef51d47f89a770236fa68ff4a

GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway

Autor: Francesca Cirillo, Marianna Talia, Maria Francesca Santolla, Michele Pellegrino, Domenica Scordamaglia, Asia Spinelli, Salvatore De Rosis, Francesca Giordano, Lucia Muglia, Azzurra Zicarelli, Marika Di Dio, Damiano Cosimo Rigiracciolo, Anna Maria Miglietta, Gianfranco Filippelli, Ernestina Marianna De Francesco, Antonino Belfiore, Rosamaria Lappano, Marcello Maggiolini

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-16 (2023)

Abstract The G protein-coupled estrogen receptor (GPER) mediates estrogen action in different pathophysiological conditions, including cancer. GPER expression and signaling have been found to join in the progression of triple-negative breast cancer (

Externí odkaz: https://doaj.org/article/2c57f1d9c7644497af4f658a91fac8cf

Oncoplastic and reconstructive surgery in SENONETWORK Italian breast centers: lights and shadows

Autor: Matteo Ghilli, Andrea Vittorio Emanuele Lisa, Marzia Salgarello, Giovanni Papa, Mario Rietjens, Secondo Folli, Annalisa Curcio, Guglielmo Ferrari, Francesco Caruso, Vittorio Altomare, Daniele Friedman, Maria Carmen De Santis, Fiorenza De Rose, Bruno Meduri, Francesca De Felice, Lorenza Marino, Francesca Cucciarelli, Stefania Montemezzi, Pietro Panizza, Paolo Belli, Francesca Caumo, Valeriano Vinci, Giorgio De Santis, Marco Klinger, Manuela Roncella, Francesco Abbonante, Ginevra Lamanna, Augusto Lombardi, Silvio Vischi, Lorenzo Orzalesi, Giovanni Angiolucci, Samantha Bozzo, Laura Pizzorno, Bettina Ballardini, Maggiorino Barbero, Leonardo Barellini, Claudio Battaglia, Luisa Reggiani, Caterina Santi, Nicoletta Biglio, Marina Bortul, Paolo Burelli, Massimo Busani, Roberta Cabula, Katia Cagossi, Vito Maria Fontanarosa, Francesca Catalano, Carla Cedolini, Luigi Ciuffreda, Fabio Corsi, Olindo Custodero, Stefano Mori, Roy De Vita, Loredana Defilippi, Samantha Marcuzzi, Stefano Drago, Giovanni Battista, Loredana Burgoa, Paolo Cristofolini, Giovanna Romanucci, Andrea Loreti, Valerio Prosperi, Paolo Carcoforo, Patrizia Fulvia Franzini, Patrizia Frittelli, Giuseppe Perniciaro, Daniele Generali, Monica Giordano, Giovanazzi Riccardo, Simona Grossi, Alessandra Huscher, Giuseppe La Torre, Gianfranco Lolli, Carla Magni, Stefano Mancini, Lorenzo Galli, Alba Di Leone, Samuele Massarut, Alberto Massocco, Monica Cramarossa, Graziano Meneghini, Luca Fabiocchi, Anna Maria Miglietta, Francesco Millo, Antonella Ciabattoni, Francesca Pellini, Marco Moschetta, Antonino Musolino, Dante Palli, Giulia Pagura, Mariagrazia Pieraccini, Davide Marenco, Romano Polato, Maria Renne, Cosmo Maurizio Ressa, Fabio Ricci, Raffaella Ridolfo, Francesca Angela Rovera, Francesco Barberini, Marina Vinciguerra, Marco Furci, Maria Sciamannini, Daniela Gianquinto, Silvia Petrucci, Angelica Della Valle, Pietra Stancampiano, Andrea Lippi, Giovanni Tazzioli, Davide Lombardi, Martino Trunfio, Luca Valieri, Carlo Vecchio, Paolo Veronesi, Gretha Grilz

Publikováno v: Breast, Vol 73, Iss , Pp 103601- (2024)

Externí odkaz: https://doaj.org/article/dde30b65788e4ae0bf1f21775c88be10

The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)

Autor: Rosamaria Lappano, Marianna Talia, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Domenica Scordamaglia, Rita Guzzi, Anna Maria Miglietta, Ernestina Marianna De Francesco, Antonino Belfiore, Andrew H. Sims, Marcello Maggiolini

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-22 (2020)

Abstract Background Hypoxia plays a relevant role in tumor-related inflammation toward the metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β (IL-β) and its cognate receptor IL1R1 contribute to the initiation

Externí odkaz: https://doaj.org/article/8a89ee80ba7942e7bce4d406d1090c33

Interleukin (IL)-11 Is Involved in the Functional Liaison between Breast Tumor Cells and the Surrounding Stroma

Autor: Marianna Talia, Francesca Cirillo, Domenica Scordamaglia, Maria Francesca Santolla, Asia Spinelli, Salvatore De Rosis, Lucia Muglia, Azzurra Zicarelli, Anna Maria Miglietta, Marcello Maggiolini, Rosamaria Lappano

Publikováno v: Biology and Life Sciences Forum, Vol 21, Iss 1, p 23 (2023)

Current advances in molecular profiling methodologies and the accessibility of multi-omics datasets are paving the way toward a better understanding of heterogeneous diseases, including breast cancer (BC). In this regard, we sought to uncover the tra

Externí odkaz: https://doaj.org/article/a9c8b202dab84dff9b64a90d6b97e00d