A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death

Autor: Simona D'Antoni, Antonio Berretta, Giovanna Seminara, Patrizia Longone, Anna Maria Giuffrida-Stella, Giuseppe Battaglia, Maria A. Sortino, Ferdinando Nicoletti, Maria V. Catania

Publikováno v: Neurobiology of Disease, Vol 42, Iss 3, Pp 252-264 (2011)

The causes of amyotrophic lateral sclerosis (ALS) are mostly undefined; however, excitotoxic injury and astrogliosis may contribute to motor neuron (MN) degeneration. Group I metabotropic glutamate (mGlu) receptors are over-expressed in reactive astr

Externí odkaz: https://doaj.org/article/046f3448424e4fbfbaf8963eb8c2acc6

Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity

Autor: Anna Maria Giuffrida Stella, Timothy E. Bates, Albena T Dinkova Kostova, Carolin Cornelius, Vittorio Calabrese, Cesare Mancuso, Francesco Bellia, Enrico Rizzarelli, Tony Schapira, Giovanni Pennisi, Stella Calafato

Publikováno v: Neurochemical research 33 (2008): 2444–2471. doi:10.1007/s11064-008-9775-9
info:cnr-pdr/source/autori:Rizzarelli, Enrico (1); Bellia, Francesco (1); Mancuso, Cesare (3); Calabrese, Vittorio (1); Cornelius, Carolin (1); Calafato, Stella (4); Giuffrida Stella, Anna Maria (1); Pennisi, Giovanni (2); Schapira, Tony (4); Bates, Timothy E. (5); Dinkova Kostova, Albena T. (7)/titolo:Cellular stress response: A novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity/doi:10.1007%2Fs11064-008-9775-9/rivista:Neurochemical research/anno:2008/pagina_da:2444/pagina_a:2471/intervallo_pagine:2444–2471/volume:33

The predominant molecular symptom of aging is the accumulation of altered gene products. Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox homeostasis and lead to accumulation of unfolded or misfolded proteins i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61e196b2b582912bdb96d1b13fcd14b
https://doi.org/10.1007/s11064-008-9775-9

Heme oxygenase and cyclooxygenase in the central nervous system: A functional interplay

Autor: Cesare Mancuso, Chiara Cini, Carlo De Marco, Marzia Perluigi, Anna Maria Giuffrida Stella, Vittorio Calabrese

Publikováno v: Journal of neuroscience research 84 (2006): 1385–1391. doi:10.1002/jnr.21049
info:cnr-pdr/source/autori:Mancuso, C (Mancuso, Cesare); Perluigi, M (Perluigi, Marzia); Cini, C (Cini, Chiara); De Marco, C (De Marco, Carlo); Stella, AMG (Stella, Anna Maria Giuffrida); Calabrese, V (Calabrese, Vittorio)/titolo:Heme oxygenase and cyclooxygenase in the central nervous system: A functional interplay/doi:10.1002%2Fjnr.21049/rivista:Journal of neuroscience research/anno:2006/pagina_da:1385/pagina_a:1391/intervallo_pagine:1385–1391/volume:84

Heme oxygenase (HO) and cyclooxygenase (COX) are two hemeproteins involved in the regulation of several functions in the nervous system. Heme oxygenase is the enzyme responsible for the degradation of heme into ferrous iron, carbon monoxide (CO), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d413688eca660934a8f6110c12b6fe7b
https://doi.org/10.1002/jnr.21049

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Autor: Eleonora Aronica, Anna Maria Giuffrida-Stella, Raffaella Giuffrida, Maria Vincenza Catania, Jan A. Gorter, Giovanna Seminara, Giuseppe Barbagallo, A. Ravagna, Vittorio Calabrese, P. Dell'Albani

Publikováno v: Neurochemical Research. 28:607-615

Neuronal nitric oxide synthase (nNOS) is a constitutively expressed and calcium-dependent enzyme. Despite predominantly expressed in neurons, nNOS has been also found in astrocytes, although at lower expression levels. We have studied the regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc4342eaa7dacc48f5426ee99c4f21bd
https://doi.org/10.1023/a:1022841911265

[Untitled]

Autor: Timothy E. Bates, Anna Maria Giuffrida Stella, Vittorio Calabrese

Publikováno v: Neurochemical Research. 25:1315-1341

Nitric oxide and other reactive nitrogen species appear to play several crucial roles in the brain. These include physiological processes such as neuromodulation, neurotransmission and synaptic plasticity, and pathological processes such as neurodege

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b37ea15b7d7d73e7d2bab5f60176d4d7
https://doi.org/10.1023/a:1007604414773