Výsledky vyhledávání - "ANM Nazmul Khan"

Role of the extracellular ATP/adenosine pathway in neutrophil-mediated T cell suppression in ovarian cancer microenvironment

Autor: Thejaswini Giridharan, Sora Suzuki, Tiffany R Emmons, ANM Nazmul Khan, Michael B Yaffe, Emese Zsiros, Kunle Odunsi, Manmeet Bhalla, Elsa Bou Ghanem, Brahm H Segal

Publikováno v: The Journal of Immunology. 208:177.15-177.15

The extracellular ATP (eATP)/adenosine (ADO) pathway is a key modulator of innate and adaptive immunity and is a target for immunotherapy for cancer. In the tumor microenvironment (TME) and conditions of chronic injury, ATP is released by dying cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::352ad40493b7736b7b2151f1d8657fa5
https://doi.org/10.4049/jimmunol.208.supp.177.15

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Complement C3 deficiency enhances anti-CD47 efficacy in murine ovarian cancer model

Autor: Sora Suzuki, Thejaswini Giridharan, ANM Nazmul Khan, Tiffany R Emmons, Michael B. Yaffe, Kipp Weiskopf, Madhumita Das, Kevin H. Eng, Emese Zsiros, Brahm H. Segal

Publikováno v: The Journal of Immunology. 208:176.14-176.14

Epithelial ovarian cancer (OC) is the most lethal gynecological malignancy. While OC is an immunogenic tumor, single-agent anti-PD-1 have limited efficacy in recurrent OC. Blockade of the CD47/SIRPα pathway, a phagocytosis checkpoint in macrophages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64c9255e2697e2654994679f7a3bc589
https://doi.org/10.4049/jimmunol.208.supp.176.14

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Mature neutrophils acquire a T cell suppressor phenotype in the ovarian cancer microenvironment characterized by disruption of key T cell signaling and metabolic responses

Autor: Thejaswini Giridharan, Tiffany R Emmons, ANM Nazmul Khan, Sora Suzuki, Aaron Varghese, Meagan Sullivan, Kunle Odunsi, Emese Zsiros, Michael B Yaffe, Brahm H Segal

Publikováno v: The Journal of Immunology. 206:101.05-101.05

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Despite being an immunogenic tumor, single-agent checkpoint inhibitor therapy in the recurrent setting has been disappointing, raising the notion of suppressive factors in the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07a72b4d7b12f20bd2f242f177451a5d
https://doi.org/10.4049/jimmunol.206.supp.101.05

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Mature neutrophils acquire a T cell suppressor phenotype in the ovarian cancer microenvironment that requires complement and NADPH oxidase activation

Autor: Tiffany Rose Emmons, Kelly L. Singel, ANM Nazmul Khan, Emad Alqassim, Anna Marie Blom, Sanjay Ram, Steven Holland, Kunle Odunsi, Emese Zsiros, Brahm H. Segal

Publikováno v: The Journal of Immunology. 202:137.13-137.13

Metastatic epithelial ovarian cancer (EOC) is associated with ascites and accumulation of immunosuppressive myeloid cells. Granulocytic myeloid-derived suppressor cells are an immature population that impairs anti-tumor immunity. We previously found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7616971ae84d5028c067cec26446952
https://doi.org/10.4049/jimmunol.202.supp.137.13

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