Zobrazeno 1 - 10
of 18 935
pro vyhledávání: '"ANDREW PIERCE"'
Autor:
Kelechi Njoku, Andrew Pierce, Davide Chiasserini, Bethany Geary, Amy E. Campbell, Janet Kelsall, Rachel Reed, Nophar Geifman, Anthony D. Whetton, Emma J. Crosbie
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105064- (2024)
Summary: Background: The anatomical continuity between the uterine cavity and the lower genital tract allows for the exploitation of uterine-derived biomaterial in cervico-vaginal fluid for endometrial cancer detection based on non-invasive sampling
Externí odkaz:
https://doaj.org/article/aa9847fd599d4a019d13e4ed6f2270e2
Autor:
Stuart Willis, Jeff Stephenson, Andrew Pierce, Lea Medeiros, Laura Jenkins, Douglas R. Hatch, Shawn Narum
Publikováno v:
Evolutionary Applications, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract Age‐at‐maturity and iteroparity are two life history variations of steelhead trout (Oncorhynchus mykiss) that are believed to increase population resilience and stability. While repeat‐spawning individuals are thought to have historica
Externí odkaz:
https://doaj.org/article/18898f6cbe984c09ada6babb8f8e8d5c
Autor:
Stella Pearson, Rognvald Blance, Fei Yan, Ya-Ching Hsieh, Bethany Geary, Fabio M R Amaral, Tim C P Somervaille, Kristina Kirschner, Anthony D Whetton, Andrew Pierce
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286412 (2023)
Myelofibrosis is a myeloproliferative neoplasm (MPN) which typically results in reduced length and quality of life due to systemic symptoms and blood count changes arising from fibrotic changes in the bone marrow. While the JAK2 inhibitor ruxolitinib
Externí odkaz:
https://doaj.org/article/68dcd073260444a9951df4bb64585f57
Autor:
Mareike Polenkowski, Aldrige Bernardus Allister, Sebastian Burbano de Lara, Andrew Pierce, Bethany Geary, Omar El Bounkari, Lutz Wiehlmann, Andrea Hoffmann, Anthony D. Whetton, Teruko Tamura, Doan Duy Hai Tran
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105784- (2023)
Summary: THOC5, a member of the THO complex, is essential for the 3′processing of some inducible genes, the export of a subset of mRNAs and stem cell survival. Here we show that THOC5 depletion results in altered 3′cleavage of >50% of mRNAs and c
Externí odkaz:
https://doaj.org/article/ea2f8fdeb28c42799228d559b21a2a93
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0266298 (2022)
Despite the big increase in precision medicine targeted therapies developing curative treatments for many cancers is still a major challenge due mainly to the development of drug resistance in cancer stem cells. The cancer stem cells are constantly e
Externí odkaz:
https://doaj.org/article/29d5104a52444955853afe0e14b6effc
Autor:
Robert Brendza, Han Lin, Kimberly Stark, Oded Foreman, Janet Tao, Andrew Pierce, Hai Ngu, Kimberle Shen, Amy E. Easton, Tushar Bhangale, Diana Chang, Baris Bingol, Brad A. Friedman
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105494- (2021)
The gene GPNMB is known to play roles in phagocytosis and tissue repair, and is upregulated in microglia in many mouse models of neurodegenerative disease as well as in human patients. Nearby genomic variants are associated with both elevated Parkins
Externí odkaz:
https://doaj.org/article/97c7b8fae8394304ad382e3b998c63c0
Autor:
Andrew Pierce, Sarbjeet Singh, JuHae Lee, Cameron Grant, Vivianne Cruz de Jesus, Robert J. Schroth
Publikováno v:
Frontiers in Public Health, Vol 7 (2019)
Introduction: Early childhood caries (ECC) is any caries in the primary dentition occurring in children under the age of six. ECC is common in many population groups in Canada.Objective: The purpose of this review was to describe the burden of ECC in
Externí odkaz:
https://doaj.org/article/6cdff5181c9c482383c9b05361d45818
Autor:
Samantha Littler, Olivia Sloss, Bethany Geary, Andrew Pierce, Anthony D. Whetton, Stephen S. Taylor
Publikováno v:
Open Biology, Vol 9, Iss 8 (2019)
The oncogenic transcription factor MYC modulates vast arrays of genes, thereby influencing numerous biological pathways including biogenesis, metabolism, proliferation, apoptosis and pluripotency. When deregulated, MYC drives genomic instability via
Externí odkaz:
https://doaj.org/article/2e86d1d135614c3a9677d1bcc536efaf
Publikováno v:
HemaSphere, Vol 3, Iss 3 (2019)
Abstract. Myeloproliferative neoplasms (MPN) are clonal stem cell associated disorders inclusive of chronic myeloid leukemia (CML), Polycythaemia vera (PV), myelofibrosis (MF), and essential thrombocythemia (ET). They are characterized by increased p
Externí odkaz:
https://doaj.org/article/a6171f4d99754bf6b8fd7dd80fe99025
Autor:
Amit P. Amin, Samantha Miller, Brandon Rahn, Mary Caruso, Andrew Pierce, Katrine Sorensen, Howard Kurz, Alan Zajarias, Richard Bach, Jasvindar Singh, John M. Lasala, Hemant Kulkarni, Patricia Crimmins‐Reda
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 21 (2018)
Background Bleeding is a common, morbid, and costly complication of percutaneous coronary intervention. While bleeding avoidance strategies (BAS) are effective, they are used paradoxically less in patients at high risk of bleeding. Whether a patient
Externí odkaz:
https://doaj.org/article/12e85cc8760d4ca9a8dfd875440f5414