Zobrazeno 1 - 10
of 629
pro vyhledávání: '"ANDREA CAVALLI"'
Autor:
Jan Kruta, Raphael Carapito, Marten Trendelenburg, Thierry Martin, Marta Rizzi, Reinhard E. Voll, Andrea Cavalli, Eriberto Natali, Patrick Meier, Marc Stawiski, Johannes Mosbacher, Annette Mollet, Aurelia Santoro, Miriam Capri, Enrico Giampieri, Erik Schkommodau, Enkelejda Miho
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Early and accurate diagnosis is crucial to prevent disease development and define therapeutic strategies. Due to predominantly unspecific symptoms, diagnosis of autoimmune diseases (AID) is notoriously challenging. Clinical decision support
Externí odkaz:
https://doaj.org/article/6b14c84f193c4cfea08961e9233c5fa1
Autor:
Beatrice Balboni, Roberto Marotta, Francesco Rinaldi, Giulia Milordini, Giulia Varignani, Stefania Girotto, Andrea Cavalli
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Human RAD52 (RAD52) is a DNA-binding protein involved in many DNA repair mechanisms and genomic stability maintenance. In the last few years, this protein was discovered to be a promising novel pharmacological target for anticancer strategie
Externí odkaz:
https://doaj.org/article/dfbf239bf1644e1fa6ef708151c25101
Autor:
Filippo Spriano, Giulio Sartori, Jacopo Sgrignani, Laura Barnabei, Alberto J. Arribas, Matilde Guala, Ana Maria Carrasco Del Amor, Meagan R. Tomasso, Chiara Tarantelli, Luciano Cascione, Gaetanina Golino, Maria E Riveiro, Roberta Bortolozzi, Antonio Lupia, Francesco Paduano, Samuel Huguet, Keyvan Rezai, Andrea Rinaldi, Francesco Margheriti, Pedro Ventura, Greta Guarda, Giosuè Costa, Roberta Rocca, Alberto Furlan, Luuk M. Verdonk, Paolo Innocenti, Nathaniel I. Martin, Giampietro Viola, Christoph Driessen, Emanuele Zucca, Anastasios Stathis, Digvijay Gahtory, Maurits van den Nieuwboer, Beat Bornhauser, Stefano Alcaro, Francesco Trapasso, Susana Cristobal, Shae B. Padrick, Natalina Pazzi, Franco Cavalli, Andrea Cavalli, Eugenio Gaudio, Francesco Bertoni
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Hematological cancers are among the most common cancers in adults and children. Despite significant improvements in therapies, many patients still succumb to the disease. Therefore, novel therapies are needed. The Wiskott-Aldrich syndrome protein (WA
Externí odkaz:
https://doaj.org/article/1fcdabe916834d5e99ed8d590cb92b6a
Publikováno v:
IEEE Access, Vol 12, Pp 155151-155167 (2024)
Bias or spurious correlations in image backgrounds can impact neural networks, causing shortcut learning (Clever Hans Effect) and hampering generalization to real-world data. ISNet, a recently introduced architecture, proposed the optimization of Lay
Externí odkaz:
https://doaj.org/article/6b2a9d1fe0b54cdd8da90a030cecffdc
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Features in images’ backgrounds can spuriously correlate with the images’ classes, representing background bias. They can influence the classifier’s decisions, causing shortcut learning (Clever Hans effect). The phenomenon generates de
Externí odkaz:
https://doaj.org/article/2cac0d332ce044e791d8fdf3f3036758
Autor:
Martina Sola, Azucena Rendon-Angel, Viviana Rojo Martinez, Jacopo Sgrignani, Claudia Magrin, Ester Piovesana, Andrea Cavalli, Paolo Paganetti, Stéphanie Papin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Tau gene mutations cause a progressive dementia and neurotoxic Tau forms deposited in neurofibrillary tangles are hallmarks of neurodegenerative tauopathies. Loss of non-canonical Tau functions may contribute to disease. In fact, Tau depleti
Externí odkaz:
https://doaj.org/article/8f761c052d23454f8cdfa0b6536595c4
Autor:
Pavel Svoboda, Jan Haviernik, Petr Bednar, Milos Matkovic, Tomás Cervantes Rincón, Jennifer Keeffe, Martin Palus, Jiri Salat, Marianna Agudelo, Michel C. Nussenzweig, Andrea Cavalli, Davide F. Robbiani, Daniel Ruzek
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113149- (2023)
Summary: Tick-borne encephalitis virus (TBEV) is a flavivirus that causes human neuroinfections and represents a growing health problem. The human monoclonal antibody T025 targets envelope protein domain III (EDIII) of TBEV and related tick-borne fla
Externí odkaz:
https://doaj.org/article/b7351abf009441de9b874b9fa9404a57
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitud
Externí odkaz:
https://doaj.org/article/31ccc9f5c1c7420b8b23b5fa45bdc9ee
Publikováno v:
IEEE Access, Vol 11, Pp 98751-98763 (2023)
In recent years the technological limits inherently present in the classical Turing paradigm of computation have sparked the development of innovative solutions based on quantum devices or analog-digital mixed approaches often based on the time evolu
Externí odkaz:
https://doaj.org/article/df0cfb2ecb514fe3aeac6f84274e47da
Autor:
Brando Poggiali, Agostino Ponzetti, Marica Malerba, Fabio Landuzzi, Federica Furia, Debora Charrance, Sara Trova, Vittoria Perseghin, Patrizia A. Falcone, Valentina Alliod, Alessandra Malossi, Pierpaolo Carassai, Ubaldo Familiari, Manuela Vecchi, Stefano Gustincich, Marina Schena, Andrea Cavalli, Alessandro Coppe
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Breast carcinoma is the most prevalent cancer among women globally. It has variable clinical courses depending on the stage and clinical-biological features. This case report describes a 56-year-old female with invasive breast cancer without estrogen
Externí odkaz:
https://doaj.org/article/c1866e6d2ab349b1b6dbca96970ae353