Zobrazeno 1 - 10
of 44
pro vyhledávání: '"ANDRE LIEBER"'
P317: Gene therapy base editors reshape single-molecule chromatin architecture of γ-globin promoters
Autor:
Stephanie Bohaczuk, Chang Li, Danilo Dubocanin, Ben Mallory, Mitchell Vollger, Andre Lieber, Andrew Stergachis
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100345- (2023)
Externí odkaz:
https://doaj.org/article/b54b44f95e034650ba6557e6d88d2fff
Autor:
Wenli Zhang, Jun Fu, Jing Liu, Hailong Wang, Maren Schiwon, Sebastian Janz, Lukas Schaffarczyk, Lukas von der Goltz, Eric Ehrke-Schulz, Johannes Dörner, Manish Solanki, Philip Boehme, Thorsten Bergmann, Andre Lieber, Chris Lauber, Andreas Dahl, Andreas Petzold, Youming Zhang, A. Francis Stewart, Anja Ehrhardt
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1698-1709 (2017)
Adenoviruses (Ads) are large human-pathogenic double-stranded DNA (dsDNA) viruses presenting an enormous natural diversity associated with a broad variety of diseases. However, only a small fraction of adenoviruses has been explored in basic virology
Externí odkaz:
https://doaj.org/article/05491b28e9a94eaaac46bab0120beb0a
Autor:
Sadia Zafar, Suvi Sorsa, Mikko Siurala, Otto Hemminki, Riikka Havunen, Victor Cervera-Carrascon, João Manuel Santos, Hongjie Wang, Andre Lieber, Tanja De Gruijl, Anna Kanerva, Akseli Hemminki
Publikováno v:
OncoImmunology, Vol 7, Iss 10 (2018)
Dendritic cells (DCs) are crucial players in promoting immune responses. Logically, adoptive DC therapy is a promising approach in cancer immunotherapy. One of the major obstacles in cancer immunotherapy in general is the immunosuppressive tumor micr
Externí odkaz:
https://doaj.org/article/7a556d7b7f594f6996f6aeb03b92aa5e
Autor:
Sadia Zafar, Suvi Parviainen, Mikko Siurala, Otto Hemminki, Riikka Havunen, Siri Tähtinen, Simona Bramante, Lotta Vassilev, Hongjie Wang, Andre Lieber, Silvio Hemmi, Tanja de Gruijl, Anna Kanerva, Akseli Hemminki
Publikováno v:
OncoImmunology, Vol 6, Iss 2 (2017)
Vaccination with dendritic cells (DCs), the most potent professional antigen-presenting cells in the body, is a promising approach in cancer immunotherapy. However, tumors induce immunosuppression in their microenvironment that suppresses and impairs
Externí odkaz:
https://doaj.org/article/566dc122487a44029d2368a84af28d7a
Quantification of designer nuclease induced mutation rates: a direct comparison of different methods
Autor:
Eric Ehrke-Schulz, Thorsten Bergmann, Maren Schiwon, Johannes Doerner, Kamola Saydaminova, Andre Lieber, Anja Ehrhardt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Designer nucleases are broadly applied to induce site-specific DNA double-strand breaks (DSB) in genomic DNA. These are repaired by nonhomologous end joining leading to insertions or deletions (in/dels) at the respective DNA-locus. To detect in/del m
Externí odkaz:
https://doaj.org/article/35b92eeca55440ae8760d06dfaab68d3
Autor:
Bo Zhang, Yuhua Yan, Jie Jin, Hongyu Lin, Zongyi Li, Xiaoyan Zhang, Jin Liu, Chao Xi, Andre Lieber, Xiaolong Fan, Liang Ran
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117976 (2015)
Adenoviruses are common pathogens. The localization of their receptors coxsackievirus and adenovirus receptor, and desmoglein-2 in cell-cell junction complexes between polarized epithelial cells represents a major challenge for adenovirus infection f
Externí odkaz:
https://doaj.org/article/935320dfe08b46b0a17fd7c3e0f41fe9
Publikováno v:
BioTechniques, Vol 20, Iss 2, Pp 278-285 (1996)
For many preclinical studies, the mouse has been an invaluable model. For hepatic studies, including gene therapy, the use of the mouse has been limited because of the inability to obtain long-term portal vein access. In this study, we have developed
Externí odkaz:
https://doaj.org/article/49ca9002670d4870832d34cbb8c4ab0f
Autor:
Irene Kuhn, Paul Harden, Maxine Bauzon, Cecile Chartier, Julie Nye, Steve Thorne, Tony Reid, Shaoheng Ni, Andre Lieber, Kerry Fisher, Len Seymour, Gabor M Rubanyi, Richard N Harkins, Terry W Hermiston
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2409 (2008)
BackgroundViral-mediated oncolysis is a novel cancer therapeutic approach with the potential to be more effective and less toxic than current therapies due to the agents selective growth and amplification in tumor cells. To date, these agents have be
Externí odkaz:
https://doaj.org/article/791544878a6041298c0ab175a5f83c9b
Autor:
Marcela Calixto Brandão Miguel, Tamiris Amanda Julio, Sebastian Vernal, Natália Aparecida de Paula, Andre Lieber, Ana Maria Roselino
Publikováno v:
Anais Brasileiros de Dermatologia v.97 n.2 2022
Anais brasileiros de dermatologia
Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
Anais Brasileiros de Dermatologia, Volume: 97, Issue: 2, Pages: 145-156, Published: 22 APR 2022
Anais brasileiros de dermatologia
Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
Anais Brasileiros de Dermatologia, Volume: 97, Issue: 2, Pages: 145-156, Published: 22 APR 2022
Background Anti-desmoglein 1 and 3 autoantibodies justify acantholysis in pemphigus; however, the pathogenesis of anti-desmoglein 2 is hypothetical. Objective To compare the participation of desmogleins 1, 2 and 3 through the production of serum auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadc70a66571ba34a2ac81a023bb6dd7
https://doi.org/10.1016/j.abd.2021.06.004
https://doi.org/10.1016/j.abd.2021.06.004
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Multiple myeloma (MM) is an incurable malignancy of the B-cell lineage. Remarkable progress has been made in the treatment of MM with anti-CD38 monoclonal antibodies such as daratumumab and isatuximab, which can kill MM cells by inducing complement-d
Externí odkaz:
https://doaj.org/article/085b2858ebc84b6db574179c60218a9e