Zobrazeno 1 - 10
of 301
pro vyhledávání: '"ANDRÁS, PERCZEL"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Aggregation-prone-motifs (APRs) of proteins are short segments, which – as isolated peptides - form diverse amyloid-like crystals. We introduce two APRs - designed variants of the incretin mimetic Exendin-4 - that both display crystal-phas
Externí odkaz:
https://doaj.org/article/f88d5d33f81b4ec39acf674e4aa1f77d
Autor:
Péter Ábrányi-Balogh, Dávid Bajusz, Zoltán Orgován, Aaron B. Keeley, László Petri, Nikolett Péczka, Tibor Viktor Szalai, Gyula Pálfy, Márton Gadanecz, Emma K. Grant, Tímea Imre, Tamás Takács, Ivan Ranđelović, Marcell Baranyi, András Marton, Gitta Schlosser, Qirat F. Ashraf, Elvin D. de Araujo, Tamás Karancsi, László Buday, József Tóvári, András Perczel, Jacob T. Bush, György M. Keserű
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Fragment screening is a popular strategy of generating viable chemical starting points especially for challenging targets. Although fragments provide a better coverage of chemical space and they have typically higher chance of binding, their
Externí odkaz:
https://doaj.org/article/0a79f05dcd144d4ba343eaa1f806db99
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Protein folds and the local environments they create can be compared using a variety of differently designed measures, such as the root mean squared deviation, the global distance test, the template modeling score or the local distance diffe
Externí odkaz:
https://doaj.org/article/ac31ebfbcad6426b8e0efc5eb662abd5
Autor:
Ádám Sturm, Éva Saskői, Bernadette Hotzi, Anna Tarnóci, János Barna, Ferenc Bodnár, Himani Sharma, Tibor Kovács, Eszter Ari, Nóra Weinhardt, Csaba Kerepesi, András Perczel, Zoltán Ivics, Tibor Vellai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mobility of transposable elements (TEs) frequently leads to insertional mutations in functional DNA regions. In the potentially immortal germline, TEs are effectively suppressed by the Piwi-piRNA pathway. However, in the genomes of ageing so
Externí odkaz:
https://doaj.org/article/a97a5bcd39594174b9e0d2f0e89b8165
Autor:
Dániel Horváth, Zsolt Dürvanger, Dóra K. Menyhárd, Máté Sulyok-Eiler, Fruzsina Bencs, Gergő Gyulai, Péter Horváth, Nóra Taricska, András Perczel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract A large group of hormones are stored as amyloid fibrils in acidic secretion vesicles before they are released into the bloodstream and readopt their functional state. Here, we identify an evolutionarily conserved hexapeptide sequence as the
Externí odkaz:
https://doaj.org/article/7faf27c85edf453f974f3266f7d1ff32
Autor:
István Vida, Zsolt Fazekas, Gergő Gyulai, Dóra Nagy‐Fazekas, Gyula Pálfy, Pál Stráner, Éva Kiss, András Perczel
Publikováno v:
Microbial Biotechnology, Vol 14, Iss 3, Pp 1107-1119 (2021)
Summary We developed a cost sensitive isotope labelling procedure using a fed‐batch fermentation method and tested its efficiency producing the 15N‐, 13C‐ and 15N/13C‐labelled variants of an amyloidogenic miniprotein (E5: EEEAVRLYIQWLKEGGPSSG
Externí odkaz:
https://doaj.org/article/134f0cff74d24c05a20c9df76da157bf
Autor:
Dóra Nagy-Fazekas, Zsolt Fazekas, Nóra Taricska, Pál Stráner, Dóra Karancsiné Menyhárd, András Perczel
Publikováno v:
Molecules, Vol 28, Iss 15, p 5655 (2023)
Myostatin, an important negative regulator of muscle mass, is a therapeutic target for muscle atrophic disorders such as muscular dystrophy. Thus, the inhibition of myostatin presents a strategy to treat these disorders. It has long been established
Externí odkaz:
https://doaj.org/article/2dd0bfd1c1184c1b8327e552cab3d597
Autor:
Dóra Nagy-Fazekas, Pál Stráner, Péter Ecsédi, Nóra Taricska, Adina Borbély, László Nyitray, András Perczel
Publikováno v:
Bioengineering, Vol 10, Iss 3, p 389 (2023)
Antibodies are key proteins of the immune system, and they are widely used for both research and theragnostic applications. Among them, camelid immunoglobulins (IgG) differ from the canonical human IgG molecules, as their light chains are completely
Externí odkaz:
https://doaj.org/article/532fcbcce04c4c5eaab7d71a9c0ff521
Publikováno v:
Journal of Chemical Information and Modeling. 62:3844-3853
On 26 November 2021, the WHO classified the Omicron variant of the SARS-CoV-2 virus (B.1.1.529 lineage) as a variant of concern (VOC) (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eaad9112d1d7eb704fcc0786db74761
https://doi.org/10.1021/acs.jcim.2c00397
https://doi.org/10.1021/acs.jcim.2c00397
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 500 (2021)
The amyloid state of proteins is widely studied with relevance to neurology, biochemistry, and biotechnology. In contrast with nearly amorphous aggregation, the amyloid state has a well-defined structure, consisting of parallel and antiparallel β-sh
Externí odkaz:
https://doaj.org/article/66aadf55656d49b5a032c87531689682